Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation

Modification of hypothalamic fatty acid (FA) metabolism can improve energy homeostasis and prevent hyperphagia and excessive weight gain in diet-induced obesity (DIO) from a diet high in saturated fatty acids. We have shown previously that C75, a stimulator of carnitine palmitoyl transferase-1 (CPT-...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e115642-e115642
Hauptverfasser:	McFadden, Joseph W, Aja, Susan, Li, Qun, Bandaru, Veera V R, Kim, Eun-Kyoung, Haughey, Norman J, Kuhajda, Francis P, Ronnett, Gabriele V
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - pharmacology Acylglycerols Acyltransferase Adenosine Triphosphate - metabolism AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Appetite Depressants - pharmacology ATP Biology and Life Sciences Body weight Body weight gain Brain Brain research Carnitine Catabolism Cell Line Cell lines Cells, Cultured Cellular stress response Ceramides Ceramides - metabolism Cholesterol Cholesterol Esters - metabolism Cricetinae Energy Energy balance Energy metabolism Esters Fatty acids Food Food intake Gene expression Glycerides - metabolism Glycerol Glycerol-3-phosphate Glycerol-3-Phosphate O-Acyltransferase - antagonists & inhibitors Homeostasis Humans Hyperphagia Hypothalamus Hypothalamus - cytology Hypothalamus - metabolism Inflammation Inflammation - metabolism Insulin resistance Kinases Lipid metabolism Lipids Liver diseases Medicine Medicine and Health Sciences Metabolic syndrome Metabolism Metabolome Mice Neurology Neurons Neurons - metabolism Neurophysiology Neurosciences Obesity ortho-Aminobenzoates - chemistry ortho-Aminobenzoates - pharmacology Oxidation Oxidation-Reduction Oxidation-reduction reactions Oxidative stress Oxygen Palmitates - metabolism Palmitic acid Phosphates Physicians Physiological aspects Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Recovery of function Rodents Saturated fatty acids Stress, Physiological Sulfonamides - chemistry Sulfonamides - pharmacology Weight control
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