SOX10 transactivates S100B to suppress Schwann cell proliferation and to promote myelination

Schwann cells are an important cell source for regenerative therapy for neural disorders. We investigated the role of the transcription factor sex determining region Y (SRY)-box 10 (SOX10) in the proliferation and myelination of Schwann cells. SOX10 is predominantly expressed in rat sciatic nerve-de...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e115400-e115400
Hauptverfasser:	Fujiwara, Sayaka, Hoshikawa, Shinya, Ueno, Takaaki, Hirata, Makoto, Saito, Taku, Ikeda, Toshiyuki, Kawaguchi, Hiroshi, Nakamura, Kozo, Tanaka, Sakae, Ogata, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyotrophic lateral sclerosis Animals Base Sequence Biology and Life Sciences Biomarkers - metabolism Cell Differentiation Cell growth Cell Line Cell Proliferation Disorders Dorsal root ganglia Ganglia Gene expression Gene Knockdown Techniques Growth factors Humans Introns - genetics Kinases Medicine Mice Molecular Sequence Data Mutation Myelin P0 Protein - metabolism Myelin Sheath - metabolism Myelination Protein Binding - genetics Proteins Rats Regulatory sequences Response Elements - genetics Rodents S100 Calcium Binding Protein beta Subunit - genetics S100 Calcium Binding Protein beta Subunit - metabolism S100b protein Schwann cells Schwann Cells - cytology Schwann Cells - metabolism Sciatic nerve Signal Transduction - genetics Signaling Sox10 protein SOXE Transcription Factors - genetics SOXE Transcription Factors - metabolism Transcription factors Transcriptional Activation - genetics
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