In vitro manganese-dependent cross-talk between Streptococcus mutans VicK and GcrR: implications for overlapping stress response pathways

Streptococcus mutans, a major acidogenic component of the dental plaque biofilm, has a key role in caries etiology. Previously, we demonstrated that the VicRK two-component signal transduction system modulates biofilm formation, oxidative stress and acid tolerance responses in S. mutans. Using in vi...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e115975-e115975
Hauptverfasser:	Downey, Jennifer S, Mashburn-Warren, Lauren, Ayala, Eduardo A, Senadheera, Dilani B, Hendrickson, Whitney K, McCall, Lathan W, Sweet, Julie G, Cvitkovitch, Dennis G, Spatafora, Grace A, Goodman, Steven D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adaptation Bacteria Bacterial infections Bacterial Proteins - genetics Bacterial Proteins - metabolism Biofilms Biology Biology and Life Sciences Cellular signal transduction Deficient mutant Dental caries Dental plaque Dental research Dentistry Deoxyribonuclease Deoxyribonucleic acid DNA Etiology Footprinting Gene expression Gene Expression Regulation, Bacterial Genetic engineering Kinases Manganese Manganese - metabolism Medicine and Health Sciences Mutation Oxidative stress Pathogenesis Pathways Phosphorylation Proteins Regulon Signal Transduction Signaling Staphylococcus aureus Streptococcus infections Streptococcus mutans Streptococcus mutans - genetics Streptococcus mutans - metabolism Streptococcus pyogenes Transcription
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