Oxidant exposure induces cysteine-rich protein 61 (CCN1) via c-Jun/AP-1 to reduce collagen expression in human dermal fibroblasts

Human skin is a primary target of oxidative stress from reactive oxygen species (ROS) generated from both extrinsic and intrinsic sources. Oxidative stress inhibits the production of collagen, the most abundant protein in skin, and thus contributes to connective tissue aging. Here we report that cys...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e115402
Hauptverfasser:	Qin, Zhaoping, Robichaud, Patrick, He, Tianyuan, Fisher, Gary J, Voorhees, John J, Quan, Taihao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Activator protein 1 Adult Aging Antioxidants Antioxidants (Nutrients) Antioxidants - pharmacology Base Sequence Binding Sites Biology and Life Sciences c-Jun protein Cells, Cultured Collagen Collagen (type I) Collagen Type I - metabolism Connective tissues Cysteine Cysteine-Rich Protein 61 - metabolism Cystine Dermatology Dermis - cytology Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - radiation effects Gene expression Growth factors Humans Hydrogen peroxide Intracellular Space - drug effects Intracellular Space - metabolism Kinases Medical schools Middle Aged Molecular Sequence Data N-Acetyl-L-cysteine Oxidants - pharmacology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - radiation effects Oxidizing agents Oxygen Promoter Regions, Genetic - genetics Protein Binding - drug effects Protein Binding - radiation effects Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Skin Studies Thiols Transcription Factor AP-1 - metabolism Transcription factors Ultraviolet Rays Young Adult
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