Anterior lamina cribrosa insertion in primary open-angle glaucoma patients and healthy subjects
To determine using swept-source optical coherence tomography (SS-OCT) whether there are differences in the location of the anterior lamina cribrosa insertion (ALI) in primary open-angle glaucoma (POAG) patients and healthy subjects. Fifty three eyes from 53 patients with POAG, and 53 eyes from 53 ag...
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| creator | Lee, Kyoung Min Kim, Tae-Woo Weinreb, Robert N Lee, Eun Ji Girard, Michaël J A Mari, Jean Martial |
| description | To determine using swept-source optical coherence tomography (SS-OCT) whether there are differences in the location of the anterior lamina cribrosa insertion (ALI) in primary open-angle glaucoma (POAG) patients and healthy subjects.
Fifty three eyes from 53 patients with POAG, and 53 eyes from 53 age-matched healthy subjects were included prospectively in Seoul National University Bundang Hospital. Twelve radial line B-scans centered on the optic disc in every half-clock-hour meridian were acquired using SS-OCT. The ALI position was assessed by measuring two parameters: (1) ALI distance (ALID)--the distance from the anterior scleral canal opening (ASCO) to the ALI; and (2) marginal anterior lamina cribrosa surface depth (mALCSD)--the perpendicular distance from the ASCO plane to the anterior lamina cribrosa surface. These parameters were compared between the two groups for each meridian.
Both ALID (256 ± 54 vs. 209 ± 37 µm, mean ± SD, p < 0.001) and mALCSD (232 ± 63 vs. 187 ± 40 µm, p < 0.001) were significantly greater in the POAG group than in the normal group. The largest difference was observed at the 6.5 o'clock and 11.5 o'clock meridians for both ALID and mALCSD. Multiple regression analysis revealed a negative correlation between age and both ALID and mALCSD in the control group, and a negative correlation between mean deviation of the visual field test and both ALID and mALCSD in the POAG group.
The ALI was displaced posteriorly in eyes with POAG compared to those of healthy controls. This finding suggests that the posteriorly located lamina cribrosa insertion is an important component of glaucomatous optic nerve excavation. |
| doi_str_mv | 10.1371/journal.pone.0114935 |
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Fifty three eyes from 53 patients with POAG, and 53 eyes from 53 age-matched healthy subjects were included prospectively in Seoul National University Bundang Hospital. Twelve radial line B-scans centered on the optic disc in every half-clock-hour meridian were acquired using SS-OCT. The ALI position was assessed by measuring two parameters: (1) ALI distance (ALID)--the distance from the anterior scleral canal opening (ASCO) to the ALI; and (2) marginal anterior lamina cribrosa surface depth (mALCSD)--the perpendicular distance from the ASCO plane to the anterior lamina cribrosa surface. These parameters were compared between the two groups for each meridian.
Both ALID (256 ± 54 vs. 209 ± 37 µm, mean ± SD, p < 0.001) and mALCSD (232 ± 63 vs. 187 ± 40 µm, p < 0.001) were significantly greater in the POAG group than in the normal group. The largest difference was observed at the 6.5 o'clock and 11.5 o'clock meridians for both ALID and mALCSD. Multiple regression analysis revealed a negative correlation between age and both ALID and mALCSD in the control group, and a negative correlation between mean deviation of the visual field test and both ALID and mALCSD in the POAG group.
The ALI was displaced posteriorly in eyes with POAG compared to those of healthy controls. This finding suggests that the posteriorly located lamina cribrosa insertion is an important component of glaucomatous optic nerve excavation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0114935</identifier><identifier>PMID: 25531761</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Basement Membrane - anatomy & histology ; Basement Membrane - diagnostic imaging ; Care and treatment ; Case-Control Studies ; Computer Science ; Correlation ; Correlation analysis ; Defects ; Excavation ; Extracellular matrix ; Eye ; Eye (anatomy) ; Female ; Glaucoma ; Glaucoma, Open-Angle - pathology ; Hospitals, University ; Humans ; Insertion ; Male ; Medical Imaging ; Medicine and Health Sciences ; Middle Aged ; Multiple regression analysis ; Open-angle glaucoma ; Optic Disk - diagnostic imaging ; Optic nerve ; Optical Coherence Tomography ; Optics ; Patients ; Position measurement ; Prospective Studies ; Radiography ; Regression Analysis ; Retina ; Signal and Image Processing ; Tomography ; Tomography, Optical Coherence ; Visual Acuity ; Visual field ; Visual fields</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e114935-e114935</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2014 Lee et al 2014 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c792t-65d69a2b15fb9f0b3f8c6f32535b559c7d9a4757a56455f0abdb4c0be8ec6d003</citedby><cites>FETCH-LOGICAL-c792t-65d69a2b15fb9f0b3f8c6f32535b559c7d9a4757a56455f0abdb4c0be8ec6d003</cites><orcidid>0000-0002-1169-6547</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273977/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273977/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25531761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03133411$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Bui, Bang V.</contributor><creatorcontrib>Lee, Kyoung Min</creatorcontrib><creatorcontrib>Kim, Tae-Woo</creatorcontrib><creatorcontrib>Weinreb, Robert N</creatorcontrib><creatorcontrib>Lee, Eun Ji</creatorcontrib><creatorcontrib>Girard, Michaël J A</creatorcontrib><creatorcontrib>Mari, Jean Martial</creatorcontrib><title>Anterior lamina cribrosa insertion in primary open-angle glaucoma patients and healthy subjects</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine using swept-source optical coherence tomography (SS-OCT) whether there are differences in the location of the anterior lamina cribrosa insertion (ALI) in primary open-angle glaucoma (POAG) patients and healthy subjects.
Fifty three eyes from 53 patients with POAG, and 53 eyes from 53 age-matched healthy subjects were included prospectively in Seoul National University Bundang Hospital. Twelve radial line B-scans centered on the optic disc in every half-clock-hour meridian were acquired using SS-OCT. The ALI position was assessed by measuring two parameters: (1) ALI distance (ALID)--the distance from the anterior scleral canal opening (ASCO) to the ALI; and (2) marginal anterior lamina cribrosa surface depth (mALCSD)--the perpendicular distance from the ASCO plane to the anterior lamina cribrosa surface. These parameters were compared between the two groups for each meridian.
Both ALID (256 ± 54 vs. 209 ± 37 µm, mean ± SD, p < 0.001) and mALCSD (232 ± 63 vs. 187 ± 40 µm, p < 0.001) were significantly greater in the POAG group than in the normal group. The largest difference was observed at the 6.5 o'clock and 11.5 o'clock meridians for both ALID and mALCSD. Multiple regression analysis revealed a negative correlation between age and both ALID and mALCSD in the control group, and a negative correlation between mean deviation of the visual field test and both ALID and mALCSD in the POAG group.
The ALI was displaced posteriorly in eyes with POAG compared to those of healthy controls. This finding suggests that the posteriorly located lamina cribrosa insertion is an important component of glaucomatous optic nerve excavation.</description><subject>Aged</subject><subject>Basement Membrane - anatomy & histology</subject><subject>Basement Membrane - diagnostic imaging</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Computer Science</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Defects</subject><subject>Excavation</subject><subject>Extracellular matrix</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - pathology</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Insertion</subject><subject>Male</subject><subject>Medical Imaging</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Multiple regression analysis</subject><subject>Open-angle glaucoma</subject><subject>Optic Disk - diagnostic imaging</subject><subject>Optic nerve</subject><subject>Optical Coherence Tomography</subject><subject>Optics</subject><subject>Patients</subject><subject>Position measurement</subject><subject>Prospective Studies</subject><subject>Radiography</subject><subject>Regression Analysis</subject><subject>Retina</subject><subject>Signal and Image Processing</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity</subject><subject>Visual field</subject><subject>Visual fields</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01r3DAQhk1padK0_6C0hkJpDruVrA9bl8IS2mYhEOjXVYxl2atFK20lOzT_vnLXCeuQQ_HBYvzMO3rHM1n2GqMlJiX-uPVDcGCXe-_0EmFMBWFPslMsSLHgBSJPj84n2YsYtwgxUnH-PDspGCO45Pg0kyvX62B8yC3sjINcBVMHHyE3LurQG-_SKd8Hs4Nwm_u9dgtwndV5Z2FQfgf5HnqjXR9zcE2-0WD7zW0eh3qrVR9fZs9asFG_mt5n2c8vn39cXC6urr-uL1ZXC1WKol9w1nABRY1ZW4sW1aStFG9JwQirGROqbATQkpXAOGWsRVA3NVWo1pVWvEGInGVvD7p766OcehMl5kRQQUlRJWJ9IBoPWzkZkh6M_BfwoZOQ_CqrJWmQZlBw1ICgAJWgjaixqnQlqhLzsdqnqdpQ73Sjkv0AdiY6_-LMRnb-RtKiJKIsk8D5QWDzIO1ydSXHGCKYEIrxDU7sh6lY8L8HHXu5M1Fpa8FpP4weKUoGOaUJffcAfbwTE9VBMmtc69Md1SgqVxRXuOAVHssuH6HS0-idUWnoWpPis4TzWUJiev2n72CIUa6_f_t_9vrXnH1_xB4GLHo7jLMZ5yA9gCoNcAy6ve8sRnLcmbtuyHFn5LQzKe3N8c-8T7pbEvIXzdUQ-A</recordid><startdate>20141222</startdate><enddate>20141222</enddate><creator>Lee, Kyoung Min</creator><creator>Kim, Tae-Woo</creator><creator>Weinreb, Robert N</creator><creator>Lee, Eun Ji</creator><creator>Girard, Michaël J A</creator><creator>Mari, Jean Martial</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1169-6547</orcidid></search><sort><creationdate>20141222</creationdate><title>Anterior lamina cribrosa insertion in primary open-angle glaucoma patients and healthy subjects</title><author>Lee, Kyoung Min ; Kim, Tae-Woo ; Weinreb, Robert N ; Lee, Eun Ji ; Girard, Michaël J A ; Mari, Jean Martial</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c792t-65d69a2b15fb9f0b3f8c6f32535b559c7d9a4757a56455f0abdb4c0be8ec6d003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Basement Membrane - anatomy & histology</topic><topic>Basement Membrane - diagnostic imaging</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Computer Science</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Defects</topic><topic>Excavation</topic><topic>Extracellular matrix</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - pathology</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Insertion</topic><topic>Male</topic><topic>Medical Imaging</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Multiple regression analysis</topic><topic>Open-angle glaucoma</topic><topic>Optic Disk - diagnostic imaging</topic><topic>Optic nerve</topic><topic>Optical Coherence Tomography</topic><topic>Optics</topic><topic>Patients</topic><topic>Position measurement</topic><topic>Prospective Studies</topic><topic>Radiography</topic><topic>Regression Analysis</topic><topic>Retina</topic><topic>Signal and Image Processing</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity</topic><topic>Visual field</topic><topic>Visual fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kyoung Min</creatorcontrib><creatorcontrib>Kim, Tae-Woo</creatorcontrib><creatorcontrib>Weinreb, Robert N</creatorcontrib><creatorcontrib>Lee, Eun Ji</creatorcontrib><creatorcontrib>Girard, Michaël J A</creatorcontrib><creatorcontrib>Mari, Jean Martial</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Kyoung Min</au><au>Kim, Tae-Woo</au><au>Weinreb, Robert N</au><au>Lee, Eun Ji</au><au>Girard, Michaël J A</au><au>Mari, Jean Martial</au><au>Bui, Bang V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anterior lamina cribrosa insertion in primary open-angle glaucoma patients and healthy subjects</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-12-22</date><risdate>2014</risdate><volume>9</volume><issue>12</issue><spage>e114935</spage><epage>e114935</epage><pages>e114935-e114935</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To determine using swept-source optical coherence tomography (SS-OCT) whether there are differences in the location of the anterior lamina cribrosa insertion (ALI) in primary open-angle glaucoma (POAG) patients and healthy subjects.
Fifty three eyes from 53 patients with POAG, and 53 eyes from 53 age-matched healthy subjects were included prospectively in Seoul National University Bundang Hospital. Twelve radial line B-scans centered on the optic disc in every half-clock-hour meridian were acquired using SS-OCT. The ALI position was assessed by measuring two parameters: (1) ALI distance (ALID)--the distance from the anterior scleral canal opening (ASCO) to the ALI; and (2) marginal anterior lamina cribrosa surface depth (mALCSD)--the perpendicular distance from the ASCO plane to the anterior lamina cribrosa surface. These parameters were compared between the two groups for each meridian.
Both ALID (256 ± 54 vs. 209 ± 37 µm, mean ± SD, p < 0.001) and mALCSD (232 ± 63 vs. 187 ± 40 µm, p < 0.001) were significantly greater in the POAG group than in the normal group. The largest difference was observed at the 6.5 o'clock and 11.5 o'clock meridians for both ALID and mALCSD. Multiple regression analysis revealed a negative correlation between age and both ALID and mALCSD in the control group, and a negative correlation between mean deviation of the visual field test and both ALID and mALCSD in the POAG group.
The ALI was displaced posteriorly in eyes with POAG compared to those of healthy controls. This finding suggests that the posteriorly located lamina cribrosa insertion is an important component of glaucomatous optic nerve excavation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25531761</pmid><doi>10.1371/journal.pone.0114935</doi><orcidid>https://orcid.org/0000-0002-1169-6547</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Basement Membrane - anatomy & histology Basement Membrane - diagnostic imaging Care and treatment Case-Control Studies Computer Science Correlation Correlation analysis Defects Excavation Extracellular matrix Eye Eye (anatomy) Female Glaucoma Glaucoma, Open-Angle - pathology Hospitals, University Humans Insertion Male Medical Imaging Medicine and Health Sciences Middle Aged Multiple regression analysis Open-angle glaucoma Optic Disk - diagnostic imaging Optic nerve Optical Coherence Tomography Optics Patients Position measurement Prospective Studies Radiography Regression Analysis Retina Signal and Image Processing Tomography Tomography, Optical Coherence Visual Acuity Visual field Visual fields |
| title | Anterior lamina cribrosa insertion in primary open-angle glaucoma patients and healthy subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T01%3A44%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anterior%20lamina%20cribrosa%20insertion%20in%20primary%20open-angle%20glaucoma%20patients%20and%20healthy%20subjects&rft.jtitle=PloS%20one&rft.au=Lee,%20Kyoung%20Min&rft.date=2014-12-22&rft.volume=9&rft.issue=12&rft.spage=e114935&rft.epage=e114935&rft.pages=e114935-e114935&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0114935&rft_dat=%3Cgale_plos_%3EA418126811%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1639494328&rft_id=info:pmid/25531761&rft_galeid=A418126811&rft_doaj_id=oai_doaj_org_article_3d0e5a260da94aa894d9b1c8e8987160&rfr_iscdi=true |