Epidemiological, clinical and histological characteristics of HBV/HDV co-infection: a retrospective cross-sectional study in Guangdong, China
The epidemiology of hepatitis D virus (HDV) in China is fairly unknown. The mechanisms whereby HDV leads to accelerated liver disease in hepatitis B virus (HBV)/HDV co-infected patients and the histological characteristics of chronic hepatitis D (CHD) patients need further investigation. The prevale...
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| Veröffentlicht in: | PloS one 2014-12, Vol.9 (12), p.e115888-e115888 |
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| creator | Liao, Baolin Zhang, Fuchun Lin, Siwei He, Haolan Liu, Yu Zhang, Jiansheng Xu, Ying Yi, Junqing Chen, Yunqing Liu, Huiyuan Wang, Zhanhui Cai, Weiping |
| description | The epidemiology of hepatitis D virus (HDV) in China is fairly unknown. The mechanisms whereby HDV leads to accelerated liver disease in hepatitis B virus (HBV)/HDV co-infected patients and the histological characteristics of chronic hepatitis D (CHD) patients need further investigation.
The prevalence of HDV was retrospectively evaluated in all consecutive hospitalized patients with chronic HBV infection from May 2005 to October 2011. HBV/HDV co-infected patients and HBV mono-infected patients were compared clinically and histologically. Significant histological abnormality was defined as significant necroinflammation (grade ≥A2) and/or significant fibrosis (stage ≥ F2).
6.5% of patients (426/6604) tested positive for IgM anti-HDV. HDV was more common in patients over 50 years old than those under 50 (11.7% vs. 5.1%, P |
| doi_str_mv | 10.1371/journal.pone.0115888 |
| format | Article |
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The prevalence of HDV was retrospectively evaluated in all consecutive hospitalized patients with chronic HBV infection from May 2005 to October 2011. HBV/HDV co-infected patients and HBV mono-infected patients were compared clinically and histologically. Significant histological abnormality was defined as significant necroinflammation (grade ≥A2) and/or significant fibrosis (stage ≥ F2).
6.5% of patients (426/6604) tested positive for IgM anti-HDV. HDV was more common in patients over 50 years old than those under 50 (11.7% vs. 5.1%, P<0.001). HBV/HDV co-infected patients had higher frequencies of end-stage liver disease (ESLD) than HBV mono-infected patients, and HDV co-infection was an independent risk factor for ESLD (OR: 1.428, 95%CI: 1.116-1.827; P = 0.005). The HBV DNA levels in the HBV/HDV group were significantly lower than the HBV group in chronic hepatitis patients (median: 6.50 log10copies/mL vs 6.80 log10copies/mL, P = 0.003), but higher than the HBV group in ESLD patients (median: 5.73 log10copies/mL vs 5.16 log10copies/mL, P<0.001). When stratified by alanine aminotransferase (ALT) level, 46.7%, 56.5% and 80.5% of CHD patients had significant necroinflammation and 86.7%, 87.0% and 90.3% had significant fibrosis with ALT 1-2×upper limit normal (ULN), 2-5×ULN and>5×ULN respectively.
The prevalence of HDV is not low in patients with chronic HBV infection. HDV may contribute to progression to ESLD through late-phase HBV DNA reactivation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0115888</identifier><identifier>PMID: 25532128</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Adult ; Aged ; Alanine ; Alanine transaminase ; China - epidemiology ; Chronic infection ; Coinfection - epidemiology ; Cross-Sectional Studies ; Deoxyribonucleic acid ; DNA ; DNA, Viral - genetics ; Epidemiology ; Family medical history ; Female ; Fibrosis ; Follow-Up Studies ; Gastroenterology ; Health risks ; Hepatitis ; Hepatitis Antibodies - blood ; Hepatitis B ; Hepatitis B - epidemiology ; Hepatitis B - virology ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis D - epidemiology ; Hepatitis D - virology ; Hepatitis delta virus ; Hepatitis Delta Virus - genetics ; Hepatitis Delta Virus - isolation & purification ; Hepatology ; Hospitals ; Humans ; Immunoglobulin M ; Infections ; Infectious diseases ; Liver ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Liver Function Tests ; Male ; Medicine and Health Sciences ; Middle Aged ; Patients ; Prevalence ; Prognosis ; Quality ; Retrospective Studies ; Risk factors ; Studies ; Viral Load ; Viruses ; Young Adult</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e115888-e115888</ispartof><rights>2014 Liao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Liao et al 2014 Liao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-116041051ea3f24b6fdf2a313dace991b85292cbbc85a5fe69ea9f597b09d3523</citedby><cites>FETCH-LOGICAL-c526t-116041051ea3f24b6fdf2a313dace991b85292cbbc85a5fe69ea9f597b09d3523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274124/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274124/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25532128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bonino, Ferruccio</contributor><creatorcontrib>Liao, Baolin</creatorcontrib><creatorcontrib>Zhang, Fuchun</creatorcontrib><creatorcontrib>Lin, Siwei</creatorcontrib><creatorcontrib>He, Haolan</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Zhang, Jiansheng</creatorcontrib><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Yi, Junqing</creatorcontrib><creatorcontrib>Chen, Yunqing</creatorcontrib><creatorcontrib>Liu, Huiyuan</creatorcontrib><creatorcontrib>Wang, Zhanhui</creatorcontrib><creatorcontrib>Cai, Weiping</creatorcontrib><title>Epidemiological, clinical and histological characteristics of HBV/HDV co-infection: a retrospective cross-sectional study in Guangdong, China</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The epidemiology of hepatitis D virus (HDV) in China is fairly unknown. The mechanisms whereby HDV leads to accelerated liver disease in hepatitis B virus (HBV)/HDV co-infected patients and the histological characteristics of chronic hepatitis D (CHD) patients need further investigation.
The prevalence of HDV was retrospectively evaluated in all consecutive hospitalized patients with chronic HBV infection from May 2005 to October 2011. HBV/HDV co-infected patients and HBV mono-infected patients were compared clinically and histologically. Significant histological abnormality was defined as significant necroinflammation (grade ≥A2) and/or significant fibrosis (stage ≥ F2).
6.5% of patients (426/6604) tested positive for IgM anti-HDV. HDV was more common in patients over 50 years old than those under 50 (11.7% vs. 5.1%, P<0.001). HBV/HDV co-infected patients had higher frequencies of end-stage liver disease (ESLD) than HBV mono-infected patients, and HDV co-infection was an independent risk factor for ESLD (OR: 1.428, 95%CI: 1.116-1.827; P = 0.005). The HBV DNA levels in the HBV/HDV group were significantly lower than the HBV group in chronic hepatitis patients (median: 6.50 log10copies/mL vs 6.80 log10copies/mL, P = 0.003), but higher than the HBV group in ESLD patients (median: 5.73 log10copies/mL vs 5.16 log10copies/mL, P<0.001). When stratified by alanine aminotransferase (ALT) level, 46.7%, 56.5% and 80.5% of CHD patients had significant necroinflammation and 86.7%, 87.0% and 90.3% had significant fibrosis with ALT 1-2×upper limit normal (ULN), 2-5×ULN and>5×ULN respectively.
The prevalence of HDV is not low in patients with chronic HBV infection. HDV may contribute to progression to ESLD through late-phase HBV DNA reactivation.</description><subject>Activation</subject><subject>Adult</subject><subject>Aged</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>China - epidemiology</subject><subject>Chronic infection</subject><subject>Coinfection - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Viral - genetics</subject><subject>Epidemiology</subject><subject>Family medical history</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>Hepatitis Antibodies - blood</subject><subject>Hepatitis B</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis D - epidemiology</subject><subject>Hepatitis D - virology</subject><subject>Hepatitis delta virus</subject><subject>Hepatitis Delta Virus - genetics</subject><subject>Hepatitis Delta Virus - isolation & purification</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoglobulin M</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Quality</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Viral Load</subject><subject>Viruses</subject><subject>Young 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one</jtitle><addtitle>PLoS One</addtitle><date>2014-12-22</date><risdate>2014</risdate><volume>9</volume><issue>12</issue><spage>e115888</spage><epage>e115888</epage><pages>e115888-e115888</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The epidemiology of hepatitis D virus (HDV) in China is fairly unknown. The mechanisms whereby HDV leads to accelerated liver disease in hepatitis B virus (HBV)/HDV co-infected patients and the histological characteristics of chronic hepatitis D (CHD) patients need further investigation.
The prevalence of HDV was retrospectively evaluated in all consecutive hospitalized patients with chronic HBV infection from May 2005 to October 2011. HBV/HDV co-infected patients and HBV mono-infected patients were compared clinically and histologically. Significant histological abnormality was defined as significant necroinflammation (grade ≥A2) and/or significant fibrosis (stage ≥ F2).
6.5% of patients (426/6604) tested positive for IgM anti-HDV. HDV was more common in patients over 50 years old than those under 50 (11.7% vs. 5.1%, P<0.001). HBV/HDV co-infected patients had higher frequencies of end-stage liver disease (ESLD) than HBV mono-infected patients, and HDV co-infection was an independent risk factor for ESLD (OR: 1.428, 95%CI: 1.116-1.827; P = 0.005). The HBV DNA levels in the HBV/HDV group were significantly lower than the HBV group in chronic hepatitis patients (median: 6.50 log10copies/mL vs 6.80 log10copies/mL, P = 0.003), but higher than the HBV group in ESLD patients (median: 5.73 log10copies/mL vs 5.16 log10copies/mL, P<0.001). When stratified by alanine aminotransferase (ALT) level, 46.7%, 56.5% and 80.5% of CHD patients had significant necroinflammation and 86.7%, 87.0% and 90.3% had significant fibrosis with ALT 1-2×upper limit normal (ULN), 2-5×ULN and>5×ULN respectively.
The prevalence of HDV is not low in patients with chronic HBV infection. HDV may contribute to progression to ESLD through late-phase HBV DNA reactivation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25532128</pmid><doi>10.1371/journal.pone.0115888</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1639490790 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activation Adult Aged Alanine Alanine transaminase China - epidemiology Chronic infection Coinfection - epidemiology Cross-Sectional Studies Deoxyribonucleic acid DNA DNA, Viral - genetics Epidemiology Family medical history Female Fibrosis Follow-Up Studies Gastroenterology Health risks Hepatitis Hepatitis Antibodies - blood Hepatitis B Hepatitis B - epidemiology Hepatitis B - virology Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis D - epidemiology Hepatitis D - virology Hepatitis delta virus Hepatitis Delta Virus - genetics Hepatitis Delta Virus - isolation & purification Hepatology Hospitals Humans Immunoglobulin M Infections Infectious diseases Liver Liver cancer Liver cirrhosis Liver diseases Liver Function Tests Male Medicine and Health Sciences Middle Aged Patients Prevalence Prognosis Quality Retrospective Studies Risk factors Studies Viral Load Viruses Young Adult |
| title | Epidemiological, clinical and histological characteristics of HBV/HDV co-infection: a retrospective cross-sectional study in Guangdong, China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T04%3A52%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epidemiological,%20clinical%20and%20histological%20characteristics%20of%20HBV/HDV%20co-infection:%20a%20retrospective%20cross-sectional%20study%20in%20Guangdong,%20China&rft.jtitle=PloS%20one&rft.au=Liao,%20Baolin&rft.date=2014-12-22&rft.volume=9&rft.issue=12&rft.spage=e115888&rft.epage=e115888&rft.pages=e115888-e115888&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0115888&rft_dat=%3Cproquest_plos_%3E1640329146%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1639490790&rft_id=info:pmid/25532128&rft_doaj_id=oai_doaj_org_article_e14e520a979a4acd8c62b69dc410f05a&rfr_iscdi=true |