Engineering an endothelialized vascular graft: a rational approach to study design in a non-human primate model

After many years of research, small diameter, synthetic vascular grafts still lack the necessary biologic integration to perform ideally in clinical settings. Endothelialization of vascular grafts has the potential to improve synthetic graft function, and endothelial outgrowth cells (EOCs) are a pro...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e115163-e115163
Hauptverfasser:	Anderson, Deirdre E J, Glynn, Jeremy J, Song, Howard K, Hinds, Monica T
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animal models Animals Anticoagulants Arteriovenous Shunt, Surgical Autografts Biology and Life Sciences Biomarkers - metabolism Biomedical engineering Blood Coagulation Blood platelets Blood Platelets - metabolism Blood Vessel Prosthesis Cell adhesion & migration Cells, Cultured Coagulation Design engineering Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium Engineering Fibrin Fibrinogen Fibrinogen - metabolism Gene expression Genotype & phenotype Grafting Grafts Growth factors Humans Hyperplasia Hyperplasia - therapy In vitro methods and tests In vivo methods and tests Inflammation Inflammation - metabolism Inflammation - pathology Markers Medicine and Health Sciences Models, Animal Nitric oxide Organ transplantation Oscillating flow Papio Performance prediction Physical Sciences Platelets Preconditioning Primates Regression analysis Regression models Research and Analysis Methods Rodents Science Shear stress Steady flow Stimulation Surgical implants Thrombosis Tissue Engineering - methods Tumor necrosis factor Tumor necrosis factor-TNF Tumor Necrosis Factors - pharmacology Tunica Intima - pathology
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