First-in-human trial of a novel suprachoroidal retinal prosthesis
Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical app...
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| Veröffentlicht in: | PloS one 2014-12, Vol.9 (12), p.e115239-e115239 |
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| creator | Ayton, Lauren N Blamey, Peter J Guymer, Robyn H Luu, Chi D Nayagam, David A X Sinclair, Nicholas C Shivdasani, Mohit N Yeoh, Jonathan McCombe, Mark F Briggs, Robert J Opie, Nicholas L Villalobos, Joel Dimitrov, Peter N Varsamidis, Mary Petoe, Matthew A McCarthy, Chris D Walker, Janine G Barnes, Nick Burkitt, Anthony N Williams, Chris E Shepherd, Robert K Allen, Penelope J |
| description | Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration.
Clinicaltrials.gov NCT01603576. |
| doi_str_mv | 10.1371/journal.pone.0115239 |
| format | Article |
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Clinicaltrials.gov NCT01603576.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0115239</identifier><identifier>PMID: 25521292</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Bionics ; Choroid - surgery ; Consortia ; Electrodes ; Engineering and Technology ; Eye (anatomy) ; FDA approval ; Female ; Hospitals ; Humans ; Male ; Medical research ; Medicine and Health Sciences ; Mental health ; Middle Aged ; Neural prostheses ; Ophthalmologic Surgical Procedures - instrumentation ; Ophthalmologic Surgical Procedures - methods ; Patients ; Postoperative Complications ; Prostheses ; Prostheses and implants ; Prosthetics ; Restoration ; Retina ; Retinitis ; Retinitis pigmentosa ; Retinitis Pigmentosa - surgery ; Safety ; Sclera - surgery ; Surgery ; Surgical implants ; Transplants & implants ; Vision ; Visual Prosthesis - adverse effects</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e115239-e115239</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Ayton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Ayton et al 2014 Ayton et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c809t-135af4652c02701e7f70df80db45adfdb04cb9b2a68d24777e72d3b5d2856d643</citedby><cites>FETCH-LOGICAL-c809t-135af4652c02701e7f70df80db45adfdb04cb9b2a68d24777e72d3b5d2856d643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270734/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270734/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25521292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ayton, Lauren N</creatorcontrib><creatorcontrib>Blamey, Peter J</creatorcontrib><creatorcontrib>Guymer, Robyn H</creatorcontrib><creatorcontrib>Luu, Chi D</creatorcontrib><creatorcontrib>Nayagam, David A X</creatorcontrib><creatorcontrib>Sinclair, Nicholas C</creatorcontrib><creatorcontrib>Shivdasani, Mohit N</creatorcontrib><creatorcontrib>Yeoh, Jonathan</creatorcontrib><creatorcontrib>McCombe, Mark F</creatorcontrib><creatorcontrib>Briggs, Robert J</creatorcontrib><creatorcontrib>Opie, Nicholas L</creatorcontrib><creatorcontrib>Villalobos, Joel</creatorcontrib><creatorcontrib>Dimitrov, Peter N</creatorcontrib><creatorcontrib>Varsamidis, Mary</creatorcontrib><creatorcontrib>Petoe, Matthew A</creatorcontrib><creatorcontrib>McCarthy, Chris D</creatorcontrib><creatorcontrib>Walker, Janine G</creatorcontrib><creatorcontrib>Barnes, Nick</creatorcontrib><creatorcontrib>Burkitt, Anthony N</creatorcontrib><creatorcontrib>Williams, Chris E</creatorcontrib><creatorcontrib>Shepherd, Robert K</creatorcontrib><creatorcontrib>Allen, Penelope J</creatorcontrib><creatorcontrib>Bionic Vision Australia Research Consortium</creatorcontrib><creatorcontrib>for the Bionic Vision Australia Research Consortium</creatorcontrib><title>First-in-human trial of a novel suprachoroidal retinal prosthesis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration.
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The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration.
Clinicaltrials.gov NCT01603576.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25521292</pmid><doi>10.1371/journal.pone.0115239</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-12, Vol.9 (12), p.e115239-e115239 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1638003890 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Biology and Life Sciences Bionics Choroid - surgery Consortia Electrodes Engineering and Technology Eye (anatomy) FDA approval Female Hospitals Humans Male Medical research Medicine and Health Sciences Mental health Middle Aged Neural prostheses Ophthalmologic Surgical Procedures - instrumentation Ophthalmologic Surgical Procedures - methods Patients Postoperative Complications Prostheses Prostheses and implants Prosthetics Restoration Retina Retinitis Retinitis pigmentosa Retinitis Pigmentosa - surgery Safety Sclera - surgery Surgery Surgical implants Transplants & implants Vision Visual Prosthesis - adverse effects |
| title | First-in-human trial of a novel suprachoroidal retinal prosthesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T15%3A45%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=First-in-human%20trial%20of%20a%20novel%20suprachoroidal%20retinal%20prosthesis&rft.jtitle=PloS%20one&rft.au=Ayton,%20Lauren%20N&rft.aucorp=Bionic%20Vision%20Australia%20Research%20Consortium&rft.date=2014-12-18&rft.volume=9&rft.issue=12&rft.spage=e115239&rft.epage=e115239&rft.pages=e115239-e115239&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0115239&rft_dat=%3Cgale_plos_%3EA418138914%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1638003890&rft_id=info:pmid/25521292&rft_galeid=A418138914&rft_doaj_id=oai_doaj_org_article_b9cb3c37192546c5b6a4c81a3d6f7157&rfr_iscdi=true |