Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout

Knockout (KO) mice that lack the dopamine transporter (SL6A3; DAT) display increased locomotion that can be attenuated, under some circumstances, by administration of drugs that normally produce psychostimulant-like effects, such as amphetamine and methylphenidate. These results have led to suggesti...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e115009-e115009
Hauptverfasser:	Hall, Frank Scott, Sora, Ichiro, Hen, René, Uhl, George R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines Animals Antagonists Attention Deficit Disorder with Hyperactivity - metabolism Attention deficit hyperactivity disorder Biology and Life Sciences Brain Cocaine Cocaine - pharmacology Complementation Dopamine Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - genetics Dopamine receptors Dopamine transporter Dopamine Uptake Inhibitors - pharmacology Drug abuse Drugs Habituation Habituation (learning) Hyperactivity Locomotion Locomotion - drug effects Medicine and Health Sciences Methylphenidate Mice Mice, Inbred C57BL Mice, Knockout Motor Activity - drug effects Motor Activity - genetics Neurosciences Pharmacology Phenols (Class of compounds) Piperidones - pharmacology Receptor, Serotonin, 5-HT1B - genetics Receptors Rodents Serotonin Serotonin - metabolism Serotonin 5-HT1 Receptor Antagonists - pharmacology Serotonin S1 receptors Spiro Compounds - pharmacology Test equipment
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