Mild electrical stimulation increases stress resistance and suppresses fat accumulation via activation of LKB1-AMPK signaling pathway in C. elegans

Electrical current at physiological strength has been applied as a therapeutic approach for various diseases. Several of our works showed that mild electrical stimulation (MES) at 0.1-ms pulse width has positive impact on organisms. But despite the growing evidence of the beneficial effects of MES,...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e114690-e114690
Hauptverfasser:	Matsuyama, Shingo, Moriuchi, Masataka, Suico, Mary Ann, Yano, Shuichiro, Morino-Koga, Saori, Shuto, Tsuyoshi, Yamanaka, Kunitoshi, Kondo, Tatsuya, Araki, Eiichi, Kai, Hirofumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Activation Adenosine Triphosphate - metabolism AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism AMP-Activated Protein Kinases - physiology Animals Biology and Life Sciences Caenorhabditis elegans Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Caenorhabditis elegans Proteins - physiology Cell Line Cell lines Cells (Biology) Cells, Cultured Electric Stimulation Electrical stimuli Fats - metabolism Gene expression Genes Health aspects Heat-Shock Response Humans LKB1 protein Localization Membrane potential Membrane Potential, Mitochondrial Mice Mitochondria Molecular chains Oxidative Stress Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Pulse duration Rats Satellite Cells, Skeletal Muscle Signal Transduction Signaling Stimulation Stress Stress, Physiological Stresses Transcription factors
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