Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome

Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites. Regular spacing and diverse firing characteristics of origins are thought to be required for efficie...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e114545-e114545
Hauptverfasser:	Bogenschutz, Naomi L, Rodriguez, Jairo, Tsukiyama, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Baking yeast Biology and Life Sciences Cancer Cell cycle Cellular biology Chromosome 3 Chromosome 6 Chromosome III Chromosome VI Chromosomes Chromosomes, Fungal - genetics Deoxyribonucleic acid DNA DNA biosynthesis DNA Replication DNA, Fungal - genetics Efficiency Gene loci Genomes Genomics Medical research Origin recognition complex Origin Recognition Complex - genetics Origins Proteins Replication Replication initiation Replication Origin - genetics Replication origins Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Yeast
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