The transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages

Legionella pneumophila is an intracellular bacterial pathogen that invades and replicates within alveolar macrophages through injection of ∼ 300 effector proteins by its Dot/Icm type IV translocation apparatus. The bona fide F-box protein, AnkB, is a nutritional virulence effector that triggers macr...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e114914-e114914
Hauptverfasser:	Price, Christopher T D, Abu Kwaik, Yousef
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Amino acids Ankyrins - genetics Apoptosis Bacteria Biological response modifiers Biology and Life Sciences Biomarkers - metabolism Cell Proliferation Cells, Cultured DNA microarrays F-box protein Gene expression Gene Expression Profiling Health aspects Human behavior Humans Immune response Immune system Immunomodulation Infection Inflammation Interferon Interleukin 10 Legionella Legionella pneumophila Legionella pneumophila - genetics Legionella pneumophila - pathogenicity Legionnaires' Disease - genetics Legionnaires' Disease - microbiology Legionnaires' disease bacterium Lipid metabolism Macrophages Macrophages - cytology Macrophages - metabolism Macrophages - microbiology Medicine and Health Sciences Metabolic pathways Metabolism Monocytes Monocytes - cytology Monocytes - metabolism Monocytes - microbiology Oligonucleotide Array Sequence Analysis Protein biosynthesis Protein synthesis Proteins Real-Time Polymerase Chain Reaction Replication Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Salmonella Signal Transduction Signaling Transcription Translocation Vacuoles - genetics Vacuoles - microbiology Virulence Virulence - genetics
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