Amelioration of hypercholesterolemia by an EGFR tyrosine kinase inhibitor in mice with liver-specific knockout of Mig-6

Mitogen-inducible gene 6 (Mig-6) is a negative feedback inhibitor of epidermal growth factor receptor (EGFR) signaling. We previously found that Mig-6 plays a critical role in the regulation of cholesterol homeostasis and in bile acid synthesis. In this study, we investigated the effects of EGFR inh...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e114782-e114782
Hauptverfasser:	Lee, Jun Choul, Park, Byung Kil, Choung, Sorim, Kim, Ji Min, Joung, Kyong Hye, Lee, Ju Hee, Kim, Koon Soon, Kim, Hyun Jin, Jeong, Jae-Wook, Rhee, Sang Dal, Ku, Bon Jeong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Analysis Animals Biology and life sciences Blotting, Western Cardiovascular disease Cells, Cultured Cholesterol Cholesterol - metabolism Density Diabetes mellitus Diet Enzyme inhibitors Epidermal growth factor Epidermal growth factor receptors Gefitinib Glucose Growth factors High cholesterol diet High density lipoprotein High fat diet Homeostasis Hospitals Hypercholesterolemia Hypercholesterolemia - metabolism Hypercholesterolemia - pathology Hypercholesterolemia - prevention & control Inhibition Inhibitors Integrases - metabolism Internal medicine Intracellular Signaling Peptides and Proteins - physiology Kinases Laboratory animals Lipids Lipids - analysis Liver Liver - drug effects Liver - metabolism Liver - pathology Low density lipoprotein Low density lipoproteins Lung cancer Male Medicine Medicine and Health Sciences Mice Mice, Knockout Mortality Negative feedback Phenols (Class of compounds) Protein Kinase Inhibitors - pharmacology Protein-tyrosine kinase Quinazolines - pharmacology R&D Receptor, Epidermal Growth Factor - antagonists & inhibitors Research & development Rodents Serum levels Statins Trans fatty acids Triglycerides Triglycerides - metabolism Tyrosine Tyrosine kinase inhibitors
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