The pseudophosphatase MK-STYX induces neurite-like outgrowths in PC12 cells

The rat pheochromocytoma PC12 cell line is a widely used system to study neuronal differentiation for which sustained activation of the extracellular signaling related kinase (ERK) pathway is required. Here, we investigate the function of MK-STYX [MAPK (mitogen-activated protein kinase) phosphoserin...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e114535-e114535
Hauptverfasser:	Flowers, Brittany M, Rusnak, Lauren E, Wong, Kristen E, Banks, Dallas A, Munyikwa, Michelle R, McFarland, Alexander G, Hinton, Shantá D
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Activation Animals Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Axonogenesis Axons Biology Biology and Life Sciences Catalysis Catalytic activity Cell adhesion & migration Cell Differentiation - physiology Cofilin Cysteine Deactivation Differentiation Enzyme inhibitors Epidermal growth factor Extracellular signal-regulated kinase Growth factors Inactivation Kinases MAP kinase MAP kinase kinase MAP Kinase Signaling System - physiology Metabolic pathways Muscle proteins Mutation Nerve growth factor Neurites - metabolism PC12 Cells Pheochromocytoma cells Phosphatase Phosphorylation Phosphoserine Protein binding Protein kinase Proteins Rats Research and Analysis Methods rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RhoA protein Rodents Science Signal transduction Signaling Threonine Tyrosine
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