Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors
Most studies have found that osteopontin (OPN) expression level is related to the poor prognosis of gastric cancer. However, few studies have examined the relationship between OPN expression and gastric precancerous diseases, and the potential role of OPN in the formation and development of GC. We i...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-12, Vol.9 (12), p.e114005-e114005 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e114005 |
|---|---|
| container_issue | 12 |
| container_start_page | e114005 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Chen, Tiejun Sun, Liping He, Caiyun Gong, Yuehua Xu, Qian Yuan, Yuan |
| description | Most studies have found that osteopontin (OPN) expression level is related to the poor prognosis of gastric cancer. However, few studies have examined the relationship between OPN expression and gastric precancerous diseases, and the potential role of OPN in the formation and development of GC. We investigated the relationships between serum OPN levels and the risks of gastric cancer (GC) and its precancerous disease, to explore the diagnostic efficacy of serum OPN level for GC and atrophic gastritis and its influencing factors.
A total of 1,452 patients were enrolled, including 609 with mild superficial gastritis (SG), 594 with atrophic gastritis (AG) and 249 with GC. The levels of serum OPN and serum Helicobacter pylori IgG antibody were detected by enzyme-linked immunosorbent assay.
Serum OPN levels increased from mild SG (1.99 ± 1.91 ng/ml) to AG (2.37 ± 2.27 ng/ml) to GC (5.94 ± 4.52 ng/ml) (P ≤ 0.002), along with increasing severity of gastric disease. OPN levels were significantly higher in patients with GC compared with the non-cancer population (2.17 ± 2.10, P < 0.0001). Serum OPN level was positively correlated with age and was higher in men than women, but was not correlated with H. pylori infection status. The area under the receiver operating characteristic curve was 0.805, the optimal cutoff was 2.56 ng/ml and the sensitivity and specificity were 74.3% and 71.8%, respectively, for the ability of serum OPN to discriminate GC.
Serum OPN expression was closely related to the risks of GC and AG, and it might be a useful marker for the discrimination of GC. OPN level was positively correlated with age and male sex, but was not affected by H. pylori infection, and it was promoted by smoking and drinking, in patients with mild SG. |
| doi_str_mv | 10.1371/journal.pone.0114005 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1632810370</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A418707962</galeid><doaj_id>oai_doaj_org_article_e32cf782a4d14645b1c8ece78e5725e7</doaj_id><sourcerecordid>A418707962</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-9e65bb90382ad77415c339e35baf0ff034762fdc4085995981380d1c1204d8f23</originalsourceid><addsrcrecordid>eNqNk11rFDEUhgdRbK3-A9EBQfRi13xOJjdCKX4sFFesehuymZPdlNnJmmSk_nszu9OyI72QXCS8ec6bnJOconiO0RxTgd9d-z50up3vfAdzhDFDiD8oTrGkZFYRRB8erU-KJzFeZ4DWVfW4OCGcCYkqeVq0VxD6bbn8-qWEm12AGJ3vSutD6RrokrPO6DRI3pZrHVNwpjS6MxBK3TWlTsHvNlk77CUX97JLsXSdbXvojOvWpdUm-RCfFo-sbiM8G-ez4sfHD98vPs8ul58WF-eXM1NJkmYSKr5aSURrohshGOaGUgmUr7RF1iLKREVsYxiquZRc1pjWqMEGE8Sa2hJ6Vrw8-O5aH9VYqKhwRUmNERUoE4sD0Xh9rXbBbXX4o7x2ai_4sFY6JGdaUECJsSJfhTWYVYyvsKnBgKiBC8JBZK_342n9aguNyWULup2YTnc6t1Fr_1sxwgWXVTZ4MxoE_6uHmNTWRQNtqzvw_f7eTBBB8JDZq3_Q-7MbqbXOCeSH8PlcM5iqc4ZrgYSsBq_5PVQeDWydyb_KuqxPAt5OAjKT4CatdR-jWlx9-392-XPKvj5iN6DbtIm-7Yd_F6cgO4Am-BgD2LsiY6SGprithhqaQo1NkcNeHD_QXdBtF9C_F4oG8A</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1632810370</pqid></control><display><type>article</type><title>Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><creator>Chen, Tiejun ; Sun, Liping ; He, Caiyun ; Gong, Yuehua ; Xu, Qian ; Yuan, Yuan</creator><contributor>Papaccio, Gianpaolo</contributor><creatorcontrib>Chen, Tiejun ; Sun, Liping ; He, Caiyun ; Gong, Yuehua ; Xu, Qian ; Yuan, Yuan ; Papaccio, Gianpaolo</creatorcontrib><description>Most studies have found that osteopontin (OPN) expression level is related to the poor prognosis of gastric cancer. However, few studies have examined the relationship between OPN expression and gastric precancerous diseases, and the potential role of OPN in the formation and development of GC. We investigated the relationships between serum OPN levels and the risks of gastric cancer (GC) and its precancerous disease, to explore the diagnostic efficacy of serum OPN level for GC and atrophic gastritis and its influencing factors.
A total of 1,452 patients were enrolled, including 609 with mild superficial gastritis (SG), 594 with atrophic gastritis (AG) and 249 with GC. The levels of serum OPN and serum Helicobacter pylori IgG antibody were detected by enzyme-linked immunosorbent assay.
Serum OPN levels increased from mild SG (1.99 ± 1.91 ng/ml) to AG (2.37 ± 2.27 ng/ml) to GC (5.94 ± 4.52 ng/ml) (P ≤ 0.002), along with increasing severity of gastric disease. OPN levels were significantly higher in patients with GC compared with the non-cancer population (2.17 ± 2.10, P < 0.0001). Serum OPN level was positively correlated with age and was higher in men than women, but was not correlated with H. pylori infection status. The area under the receiver operating characteristic curve was 0.805, the optimal cutoff was 2.56 ng/ml and the sensitivity and specificity were 74.3% and 71.8%, respectively, for the ability of serum OPN to discriminate GC.
Serum OPN expression was closely related to the risks of GC and AG, and it might be a useful marker for the discrimination of GC. OPN level was positively correlated with age and male sex, but was not affected by H. pylori infection, and it was promoted by smoking and drinking, in patients with mild SG.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0114005</identifier><identifier>PMID: 25479069</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biocompatibility ; Biomarkers ; Biomedical materials ; Bone density ; Cancer ; Correlation ; Cytokines ; Diagnostic systems ; Disease ; Disease prevention ; Education ; Endoscopy ; Enzyme-linked immunosorbent assay ; Enzymes ; Etiology ; Female ; Gastric cancer ; Gastritis ; Gastritis, Atrophic - blood ; Gastritis, Atrophic - genetics ; Gene Expression Regulation ; Guanylate cyclase ; Health aspects ; Health risks ; Helicobacter infections ; Helicobacter pylori ; Helicobacter pylori - pathogenicity ; Hospitals ; Humans ; IgG antibody ; Immunoglobulin G ; Infections ; Laboratories ; Male ; Medical diagnosis ; Medical prognosis ; Medical screening ; Medicine and Health Sciences ; Metastasis ; Middle Aged ; Osteopontin ; Osteopontin - blood ; Patients ; Prognosis ; Signal transduction ; Smoking ; Stomach cancer ; Stomach Neoplasms - blood ; Stomach Neoplasms - genetics ; Surgery ; Womens health</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e114005-e114005</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Chen et al 2014 Chen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9e65bb90382ad77415c339e35baf0ff034762fdc4085995981380d1c1204d8f23</citedby><cites>FETCH-LOGICAL-c692t-9e65bb90382ad77415c339e35baf0ff034762fdc4085995981380d1c1204d8f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257596/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257596/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25479069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Papaccio, Gianpaolo</contributor><creatorcontrib>Chen, Tiejun</creatorcontrib><creatorcontrib>Sun, Liping</creatorcontrib><creatorcontrib>He, Caiyun</creatorcontrib><creatorcontrib>Gong, Yuehua</creatorcontrib><creatorcontrib>Xu, Qian</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><title>Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Most studies have found that osteopontin (OPN) expression level is related to the poor prognosis of gastric cancer. However, few studies have examined the relationship between OPN expression and gastric precancerous diseases, and the potential role of OPN in the formation and development of GC. We investigated the relationships between serum OPN levels and the risks of gastric cancer (GC) and its precancerous disease, to explore the diagnostic efficacy of serum OPN level for GC and atrophic gastritis and its influencing factors.
A total of 1,452 patients were enrolled, including 609 with mild superficial gastritis (SG), 594 with atrophic gastritis (AG) and 249 with GC. The levels of serum OPN and serum Helicobacter pylori IgG antibody were detected by enzyme-linked immunosorbent assay.
Serum OPN levels increased from mild SG (1.99 ± 1.91 ng/ml) to AG (2.37 ± 2.27 ng/ml) to GC (5.94 ± 4.52 ng/ml) (P ≤ 0.002), along with increasing severity of gastric disease. OPN levels were significantly higher in patients with GC compared with the non-cancer population (2.17 ± 2.10, P < 0.0001). Serum OPN level was positively correlated with age and was higher in men than women, but was not correlated with H. pylori infection status. The area under the receiver operating characteristic curve was 0.805, the optimal cutoff was 2.56 ng/ml and the sensitivity and specificity were 74.3% and 71.8%, respectively, for the ability of serum OPN to discriminate GC.
Serum OPN expression was closely related to the risks of GC and AG, and it might be a useful marker for the discrimination of GC. OPN level was positively correlated with age and male sex, but was not affected by H. pylori infection, and it was promoted by smoking and drinking, in patients with mild SG.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biocompatibility</subject><subject>Biomarkers</subject><subject>Biomedical materials</subject><subject>Bone density</subject><subject>Cancer</subject><subject>Correlation</subject><subject>Cytokines</subject><subject>Diagnostic systems</subject><subject>Disease</subject><subject>Disease prevention</subject><subject>Education</subject><subject>Endoscopy</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Etiology</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastritis</subject><subject>Gastritis, Atrophic - blood</subject><subject>Gastritis, Atrophic - genetics</subject><subject>Gene Expression Regulation</subject><subject>Guanylate cyclase</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Helicobacter infections</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - pathogenicity</subject><subject>Hospitals</subject><subject>Humans</subject><subject>IgG antibody</subject><subject>Immunoglobulin G</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medical screening</subject><subject>Medicine and Health Sciences</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Osteopontin</subject><subject>Osteopontin - blood</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Signal transduction</subject><subject>Smoking</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - blood</subject><subject>Stomach Neoplasms - genetics</subject><subject>Surgery</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9EBQfRi13xOJjdCKX4sFFesehuymZPdlNnJmmSk_nszu9OyI72QXCS8ec6bnJOconiO0RxTgd9d-z50up3vfAdzhDFDiD8oTrGkZFYRRB8erU-KJzFeZ4DWVfW4OCGcCYkqeVq0VxD6bbn8-qWEm12AGJ3vSutD6RrokrPO6DRI3pZrHVNwpjS6MxBK3TWlTsHvNlk77CUX97JLsXSdbXvojOvWpdUm-RCfFo-sbiM8G-ez4sfHD98vPs8ul58WF-eXM1NJkmYSKr5aSURrohshGOaGUgmUr7RF1iLKREVsYxiquZRc1pjWqMEGE8Sa2hJ6Vrw8-O5aH9VYqKhwRUmNERUoE4sD0Xh9rXbBbXX4o7x2ai_4sFY6JGdaUECJsSJfhTWYVYyvsKnBgKiBC8JBZK_342n9aguNyWULup2YTnc6t1Fr_1sxwgWXVTZ4MxoE_6uHmNTWRQNtqzvw_f7eTBBB8JDZq3_Q-7MbqbXOCeSH8PlcM5iqc4ZrgYSsBq_5PVQeDWydyb_KuqxPAt5OAjKT4CatdR-jWlx9-392-XPKvj5iN6DbtIm-7Yd_F6cgO4Am-BgD2LsiY6SGprithhqaQo1NkcNeHD_QXdBtF9C_F4oG8A</recordid><startdate>20141205</startdate><enddate>20141205</enddate><creator>Chen, Tiejun</creator><creator>Sun, Liping</creator><creator>He, Caiyun</creator><creator>Gong, Yuehua</creator><creator>Xu, Qian</creator><creator>Yuan, Yuan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141205</creationdate><title>Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors</title><author>Chen, Tiejun ; Sun, Liping ; He, Caiyun ; Gong, Yuehua ; Xu, Qian ; Yuan, Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-9e65bb90382ad77415c339e35baf0ff034762fdc4085995981380d1c1204d8f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biocompatibility</topic><topic>Biomarkers</topic><topic>Biomedical materials</topic><topic>Bone density</topic><topic>Cancer</topic><topic>Correlation</topic><topic>Cytokines</topic><topic>Diagnostic systems</topic><topic>Disease</topic><topic>Disease prevention</topic><topic>Education</topic><topic>Endoscopy</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Etiology</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gastritis</topic><topic>Gastritis, Atrophic - blood</topic><topic>Gastritis, Atrophic - genetics</topic><topic>Gene Expression Regulation</topic><topic>Guanylate cyclase</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Helicobacter infections</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - pathogenicity</topic><topic>Hospitals</topic><topic>Humans</topic><topic>IgG antibody</topic><topic>Immunoglobulin G</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Medical screening</topic><topic>Medicine and Health Sciences</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Osteopontin</topic><topic>Osteopontin - blood</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Signal transduction</topic><topic>Smoking</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - blood</topic><topic>Stomach Neoplasms - genetics</topic><topic>Surgery</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Tiejun</creatorcontrib><creatorcontrib>Sun, Liping</creatorcontrib><creatorcontrib>He, Caiyun</creatorcontrib><creatorcontrib>Gong, Yuehua</creatorcontrib><creatorcontrib>Xu, Qian</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Agriculture & Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Tiejun</au><au>Sun, Liping</au><au>He, Caiyun</au><au>Gong, Yuehua</au><au>Xu, Qian</au><au>Yuan, Yuan</au><au>Papaccio, Gianpaolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-12-05</date><risdate>2014</risdate><volume>9</volume><issue>12</issue><spage>e114005</spage><epage>e114005</epage><pages>e114005-e114005</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Most studies have found that osteopontin (OPN) expression level is related to the poor prognosis of gastric cancer. However, few studies have examined the relationship between OPN expression and gastric precancerous diseases, and the potential role of OPN in the formation and development of GC. We investigated the relationships between serum OPN levels and the risks of gastric cancer (GC) and its precancerous disease, to explore the diagnostic efficacy of serum OPN level for GC and atrophic gastritis and its influencing factors.
A total of 1,452 patients were enrolled, including 609 with mild superficial gastritis (SG), 594 with atrophic gastritis (AG) and 249 with GC. The levels of serum OPN and serum Helicobacter pylori IgG antibody were detected by enzyme-linked immunosorbent assay.
Serum OPN levels increased from mild SG (1.99 ± 1.91 ng/ml) to AG (2.37 ± 2.27 ng/ml) to GC (5.94 ± 4.52 ng/ml) (P ≤ 0.002), along with increasing severity of gastric disease. OPN levels were significantly higher in patients with GC compared with the non-cancer population (2.17 ± 2.10, P < 0.0001). Serum OPN level was positively correlated with age and was higher in men than women, but was not correlated with H. pylori infection status. The area under the receiver operating characteristic curve was 0.805, the optimal cutoff was 2.56 ng/ml and the sensitivity and specificity were 74.3% and 71.8%, respectively, for the ability of serum OPN to discriminate GC.
Serum OPN expression was closely related to the risks of GC and AG, and it might be a useful marker for the discrimination of GC. OPN level was positively correlated with age and male sex, but was not affected by H. pylori infection, and it was promoted by smoking and drinking, in patients with mild SG.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25479069</pmid><doi>10.1371/journal.pone.0114005</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-12, Vol.9 (12), p.e114005-e114005 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1632810370 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adolescent Adult Aged Aged, 80 and over Biocompatibility Biomarkers Biomedical materials Bone density Cancer Correlation Cytokines Diagnostic systems Disease Disease prevention Education Endoscopy Enzyme-linked immunosorbent assay Enzymes Etiology Female Gastric cancer Gastritis Gastritis, Atrophic - blood Gastritis, Atrophic - genetics Gene Expression Regulation Guanylate cyclase Health aspects Health risks Helicobacter infections Helicobacter pylori Helicobacter pylori - pathogenicity Hospitals Humans IgG antibody Immunoglobulin G Infections Laboratories Male Medical diagnosis Medical prognosis Medical screening Medicine and Health Sciences Metastasis Middle Aged Osteopontin Osteopontin - blood Patients Prognosis Signal transduction Smoking Stomach cancer Stomach Neoplasms - blood Stomach Neoplasms - genetics Surgery Womens health |
| title | Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T09%3A26%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20OPN%20expression%20for%20identification%20of%20gastric%20cancer%20and%20atrophic%20gastritis%20and%20its%20influencing%20factors&rft.jtitle=PloS%20one&rft.au=Chen,%20Tiejun&rft.date=2014-12-05&rft.volume=9&rft.issue=12&rft.spage=e114005&rft.epage=e114005&rft.pages=e114005-e114005&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0114005&rft_dat=%3Cgale_plos_%3EA418707962%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1632810370&rft_id=info:pmid/25479069&rft_galeid=A418707962&rft_doaj_id=oai_doaj_org_article_e32cf782a4d14645b1c8ece78e5725e7&rfr_iscdi=true |