Computational modeling reveals key contributions of KCNQ and hERG currents to the malleability of uterine action potentials underpinning labor

The electrical excitability of uterine smooth muscle cells is a key determinant of the contraction of the organ during labor and is manifested by spontaneous, periodic action potentials (APs). Near the end of term, APs vary in shape and size reflecting an ability to change the frequency, duration an...

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Veröffentlicht in:PloS one 2014-12, Vol.9 (12), p.e114034
Hauptverfasser: Tong, Wing-Chiu, Tribe, Rachel M, Smith, Roger, Taggart, Michael J
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Sprache:eng
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