Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas

Papillomaviruses (PVs) induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and tissue tropism and then their genomic diversities. A laboratory mouse papillomavirus, MmuPV1 (formerly MusPV), was horizontally transmitted wi...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e113582-e113582
Hauptverfasser:	Sundberg, John P, Stearns, Timothy M, Joh, Joongho, Proctor, Mary, Ingle, Arvind, Silva, Kathleen A, Dadras, Soheil S, Jenson, A Bennett, Ghim, Shin-je
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism Basal cell carcinoma Biology and Life Sciences Cancer Carcinoma Cell morphology Connective tissues Cytology DNA, Viral - analysis DNA-Activated Protein Kinase - deficiency DNA-Activated Protein Kinase - genetics DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endophytes Female Forkhead Transcription Factors - deficiency Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Genes Hair Health aspects Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human papillomavirus Humans Immune status Inbreeding Infection Infections Inoculation Inoculum Invasiveness Keratin Laboratories Lesions Lymphocytes Lymphocytes B Lymphocytes T Male Mammals Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Nude Morphology Mutation Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - metabolism Papilloma Papilloma - metabolism Papilloma - pathology Papilloma - virology Papillomaviridae Papillomaviridae - genetics Papillomaviridae - pathogenicity Papillomavirus Regression analysis Rodents Skin Skin - metabolism Skin cancer Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Neoplasms - virology Species classification Squamous cell carcinoma Squamous cells Stem cells T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Tropism Tumors Vagina Viruses West Nile virus
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