A deficit in face-voice integration in developing vervet monkeys exposed to ethanol during gestation
Children with fetal alcohol spectrum disorders display behavioural and intellectual impairments that strongly implicate dysfunction within the frontal cortex. Deficits in social behaviour and cognition are amongst the most pervasive outcomes of prenatal ethanol exposure. Our naturalistic vervet monk...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-12, Vol.9 (12), p.e114100-e114100 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e114100 |
|---|---|
| container_issue | 12 |
| container_start_page | e114100 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Zangenehpour, Shahin Javadi, Pasha Ervin, Frank R Palmour, Roberta M Ptito, Maurice |
| description | Children with fetal alcohol spectrum disorders display behavioural and intellectual impairments that strongly implicate dysfunction within the frontal cortex. Deficits in social behaviour and cognition are amongst the most pervasive outcomes of prenatal ethanol exposure. Our naturalistic vervet monkey model of fetal alcohol exposure (FAE) provides an unparalleled opportunity to study the neurobehavioral outcomes of prenatal ethanol exposure in a controlled experimental setting. Recent work has revealed a significant reduction of the neuronal population in the frontal lobes of these monkeys. We used an intersensory matching procedure to investigate audiovisual perception of socially relevant stimuli in young FAE vervet monkeys. Here we show a domain-specific deficit in audiovisual integration of socially relevant stimuli. When FAE monkeys were shown a pair of side-by-side videos of a monkey concurrently presenting two different calls along with a single audio track matching the content of one of the calls, they were not able to match the correct video to the single audio track. This was manifest by their average looking time being equally spent towards both the matching and non-matching videos. However, a group of normally developing monkeys exhibited a significant preference for the non-matching video. This inability to integrate and thereby discriminate audiovisual stimuli was confined to the integration of faces and voices as revealed by the monkeys' ability to match a dynamic face to a complex tone or a black-and-white checkerboard to a pure tone, presumably based on duration and/or onset-offset synchrony. Together, these results suggest that prenatal ethanol exposure negatively affects a specific domain of audiovisual integration. This deficit is confined to the integration of information that is presented by the face and the voice and does not affect more elementary aspects of sensory integration. |
| doi_str_mv | 10.1371/journal.pone.0114100 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1629929538</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A416969224</galeid><doaj_id>oai_doaj_org_article_e60aaf9f3b9649a9ab84bfa8d5749815</doaj_id><sourcerecordid>A416969224</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-601f6d9f483eb50875bb0a2f5b183453155dcefcb60c6c20067152a4f072695f3</originalsourceid><addsrcrecordid>eNqNk02L2zAQhk1p6W7T_oPSGgqlPSSVZEmxLoWw9COwsNCvq5DlkaPUsVJJDrv_vvLGu8RlD8UH29IzrzTvzGTZS4wWuFjiD1vX-061i73rYIEwphihR9k5FgWZc4KKxyffZ9mzELYIsaLk_Gl2RhhdoiVh51m9ymswVtuY2y43SsP84KyG9Beh8Spa1w07NRygdXvbNfkB_AFivnPdb7gJOVzvXYA6jy6HuFGda_O69wPYQIi3As-zJ0a1AV6M71n28_OnHxdf55dXX9YXq8u55oLEOUfY8FoYWhZQMVQuWVUhRQyrcFlQVmDGag1GVxxprglCfIkZUdSkVLhgpphlr4-6-9YFORoUJOZECCJS8olYH4naqa3ce7tT_kY6ZeXtgvONVD5a3YIEjpQywhSV4FQooaqSVkaVNVtSUWKWtD6Op_XVDtLNuuhVOxGd7nR2Ixt3kDTZL1JtZtm7UcC7P30yS-5s0NC2qgPXD_cuKClRqm1C3_yDPpzdSDUqJWA749K5ehCVK4q5SC4TmqjFA1R6athZnbrJ2LQ-CXg_CUhMhOvYqD4Euf7-7f_Zq19T9u0JuwHVxk1wbT-0TJiC9Ahq70LwYO5NxkgOw3DnhhyGQY7DkMJenRboPuiu-4u_vg4Efw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1629929538</pqid></control><display><type>article</type><title>A deficit in face-voice integration in developing vervet monkeys exposed to ethanol during gestation</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Zangenehpour, Shahin ; Javadi, Pasha ; Ervin, Frank R ; Palmour, Roberta M ; Ptito, Maurice</creator><contributor>Frasch, Martin Gerbert</contributor><creatorcontrib>Zangenehpour, Shahin ; Javadi, Pasha ; Ervin, Frank R ; Palmour, Roberta M ; Ptito, Maurice ; Frasch, Martin Gerbert</creatorcontrib><description>Children with fetal alcohol spectrum disorders display behavioural and intellectual impairments that strongly implicate dysfunction within the frontal cortex. Deficits in social behaviour and cognition are amongst the most pervasive outcomes of prenatal ethanol exposure. Our naturalistic vervet monkey model of fetal alcohol exposure (FAE) provides an unparalleled opportunity to study the neurobehavioral outcomes of prenatal ethanol exposure in a controlled experimental setting. Recent work has revealed a significant reduction of the neuronal population in the frontal lobes of these monkeys. We used an intersensory matching procedure to investigate audiovisual perception of socially relevant stimuli in young FAE vervet monkeys. Here we show a domain-specific deficit in audiovisual integration of socially relevant stimuli. When FAE monkeys were shown a pair of side-by-side videos of a monkey concurrently presenting two different calls along with a single audio track matching the content of one of the calls, they were not able to match the correct video to the single audio track. This was manifest by their average looking time being equally spent towards both the matching and non-matching videos. However, a group of normally developing monkeys exhibited a significant preference for the non-matching video. This inability to integrate and thereby discriminate audiovisual stimuli was confined to the integration of faces and voices as revealed by the monkeys' ability to match a dynamic face to a complex tone or a black-and-white checkerboard to a pure tone, presumably based on duration and/or onset-offset synchrony. Together, these results suggest that prenatal ethanol exposure negatively affects a specific domain of audiovisual integration. This deficit is confined to the integration of information that is presented by the face and the voice and does not affect more elementary aspects of sensory integration.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0114100</identifier><identifier>PMID: 25470725</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alcohol use ; Alcohols ; Animals ; Behavior, Animal ; Biology and Life Sciences ; Cercopithecus aethiops ; Children ; Chlorocebus ; Cognition ; Cortex (frontal) ; Cortex (somatosensory) ; Disease Models, Animal ; Ethanol ; Exposure ; Face ; Face - physiology ; Female ; Fetal Alcohol Spectrum Disorders - pathology ; Fetal Alcohol Spectrum Disorders - veterinary ; Fetal alcohol syndrome ; Gestation ; Macaca mulatta ; Male ; Matching ; Medicine and Health Sciences ; Monkeys ; Pregnancy ; Pregnant women ; Prenatal experience ; Sensory integration ; Social behavior ; Social interactions ; Stimuli ; Vocalization, Animal - physiology</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e114100-e114100</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Zangenehpour et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Zangenehpour et al 2014 Zangenehpour et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-601f6d9f483eb50875bb0a2f5b183453155dcefcb60c6c20067152a4f072695f3</citedby><cites>FETCH-LOGICAL-c692t-601f6d9f483eb50875bb0a2f5b183453155dcefcb60c6c20067152a4f072695f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254919/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254919/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25470725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Frasch, Martin Gerbert</contributor><creatorcontrib>Zangenehpour, Shahin</creatorcontrib><creatorcontrib>Javadi, Pasha</creatorcontrib><creatorcontrib>Ervin, Frank R</creatorcontrib><creatorcontrib>Palmour, Roberta M</creatorcontrib><creatorcontrib>Ptito, Maurice</creatorcontrib><title>A deficit in face-voice integration in developing vervet monkeys exposed to ethanol during gestation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Children with fetal alcohol spectrum disorders display behavioural and intellectual impairments that strongly implicate dysfunction within the frontal cortex. Deficits in social behaviour and cognition are amongst the most pervasive outcomes of prenatal ethanol exposure. Our naturalistic vervet monkey model of fetal alcohol exposure (FAE) provides an unparalleled opportunity to study the neurobehavioral outcomes of prenatal ethanol exposure in a controlled experimental setting. Recent work has revealed a significant reduction of the neuronal population in the frontal lobes of these monkeys. We used an intersensory matching procedure to investigate audiovisual perception of socially relevant stimuli in young FAE vervet monkeys. Here we show a domain-specific deficit in audiovisual integration of socially relevant stimuli. When FAE monkeys were shown a pair of side-by-side videos of a monkey concurrently presenting two different calls along with a single audio track matching the content of one of the calls, they were not able to match the correct video to the single audio track. This was manifest by their average looking time being equally spent towards both the matching and non-matching videos. However, a group of normally developing monkeys exhibited a significant preference for the non-matching video. This inability to integrate and thereby discriminate audiovisual stimuli was confined to the integration of faces and voices as revealed by the monkeys' ability to match a dynamic face to a complex tone or a black-and-white checkerboard to a pure tone, presumably based on duration and/or onset-offset synchrony. Together, these results suggest that prenatal ethanol exposure negatively affects a specific domain of audiovisual integration. This deficit is confined to the integration of information that is presented by the face and the voice and does not affect more elementary aspects of sensory integration.</description><subject>Alcohol use</subject><subject>Alcohols</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biology and Life Sciences</subject><subject>Cercopithecus aethiops</subject><subject>Children</subject><subject>Chlorocebus</subject><subject>Cognition</subject><subject>Cortex (frontal)</subject><subject>Cortex (somatosensory)</subject><subject>Disease Models, Animal</subject><subject>Ethanol</subject><subject>Exposure</subject><subject>Face</subject><subject>Face - physiology</subject><subject>Female</subject><subject>Fetal Alcohol Spectrum Disorders - pathology</subject><subject>Fetal Alcohol Spectrum Disorders - veterinary</subject><subject>Fetal alcohol syndrome</subject><subject>Gestation</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Matching</subject><subject>Medicine and Health Sciences</subject><subject>Monkeys</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Prenatal experience</subject><subject>Sensory integration</subject><subject>Social behavior</subject><subject>Social interactions</subject><subject>Stimuli</subject><subject>Vocalization, Animal - physiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk02L2zAQhk1p6W7T_oPSGgqlPSSVZEmxLoWw9COwsNCvq5DlkaPUsVJJDrv_vvLGu8RlD8UH29IzrzTvzGTZS4wWuFjiD1vX-061i73rYIEwphihR9k5FgWZc4KKxyffZ9mzELYIsaLk_Gl2RhhdoiVh51m9ymswVtuY2y43SsP84KyG9Beh8Spa1w07NRygdXvbNfkB_AFivnPdb7gJOVzvXYA6jy6HuFGda_O69wPYQIi3As-zJ0a1AV6M71n28_OnHxdf55dXX9YXq8u55oLEOUfY8FoYWhZQMVQuWVUhRQyrcFlQVmDGag1GVxxprglCfIkZUdSkVLhgpphlr4-6-9YFORoUJOZECCJS8olYH4naqa3ce7tT_kY6ZeXtgvONVD5a3YIEjpQywhSV4FQooaqSVkaVNVtSUWKWtD6Op_XVDtLNuuhVOxGd7nR2Ixt3kDTZL1JtZtm7UcC7P30yS-5s0NC2qgPXD_cuKClRqm1C3_yDPpzdSDUqJWA749K5ehCVK4q5SC4TmqjFA1R6athZnbrJ2LQ-CXg_CUhMhOvYqD4Euf7-7f_Zq19T9u0JuwHVxk1wbT-0TJiC9Ahq70LwYO5NxkgOw3DnhhyGQY7DkMJenRboPuiu-4u_vg4Efw</recordid><startdate>20141203</startdate><enddate>20141203</enddate><creator>Zangenehpour, Shahin</creator><creator>Javadi, Pasha</creator><creator>Ervin, Frank R</creator><creator>Palmour, Roberta M</creator><creator>Ptito, Maurice</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141203</creationdate><title>A deficit in face-voice integration in developing vervet monkeys exposed to ethanol during gestation</title><author>Zangenehpour, Shahin ; Javadi, Pasha ; Ervin, Frank R ; Palmour, Roberta M ; Ptito, Maurice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-601f6d9f483eb50875bb0a2f5b183453155dcefcb60c6c20067152a4f072695f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alcohol use</topic><topic>Alcohols</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Biology and Life Sciences</topic><topic>Cercopithecus aethiops</topic><topic>Children</topic><topic>Chlorocebus</topic><topic>Cognition</topic><topic>Cortex (frontal)</topic><topic>Cortex (somatosensory)</topic><topic>Disease Models, Animal</topic><topic>Ethanol</topic><topic>Exposure</topic><topic>Face</topic><topic>Face - physiology</topic><topic>Female</topic><topic>Fetal Alcohol Spectrum Disorders - pathology</topic><topic>Fetal Alcohol Spectrum Disorders - veterinary</topic><topic>Fetal alcohol syndrome</topic><topic>Gestation</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Matching</topic><topic>Medicine and Health Sciences</topic><topic>Monkeys</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Prenatal experience</topic><topic>Sensory integration</topic><topic>Social behavior</topic><topic>Social interactions</topic><topic>Stimuli</topic><topic>Vocalization, Animal - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zangenehpour, Shahin</creatorcontrib><creatorcontrib>Javadi, Pasha</creatorcontrib><creatorcontrib>Ervin, Frank R</creatorcontrib><creatorcontrib>Palmour, Roberta M</creatorcontrib><creatorcontrib>Ptito, Maurice</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zangenehpour, Shahin</au><au>Javadi, Pasha</au><au>Ervin, Frank R</au><au>Palmour, Roberta M</au><au>Ptito, Maurice</au><au>Frasch, Martin Gerbert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A deficit in face-voice integration in developing vervet monkeys exposed to ethanol during gestation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-12-03</date><risdate>2014</risdate><volume>9</volume><issue>12</issue><spage>e114100</spage><epage>e114100</epage><pages>e114100-e114100</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Children with fetal alcohol spectrum disorders display behavioural and intellectual impairments that strongly implicate dysfunction within the frontal cortex. Deficits in social behaviour and cognition are amongst the most pervasive outcomes of prenatal ethanol exposure. Our naturalistic vervet monkey model of fetal alcohol exposure (FAE) provides an unparalleled opportunity to study the neurobehavioral outcomes of prenatal ethanol exposure in a controlled experimental setting. Recent work has revealed a significant reduction of the neuronal population in the frontal lobes of these monkeys. We used an intersensory matching procedure to investigate audiovisual perception of socially relevant stimuli in young FAE vervet monkeys. Here we show a domain-specific deficit in audiovisual integration of socially relevant stimuli. When FAE monkeys were shown a pair of side-by-side videos of a monkey concurrently presenting two different calls along with a single audio track matching the content of one of the calls, they were not able to match the correct video to the single audio track. This was manifest by their average looking time being equally spent towards both the matching and non-matching videos. However, a group of normally developing monkeys exhibited a significant preference for the non-matching video. This inability to integrate and thereby discriminate audiovisual stimuli was confined to the integration of faces and voices as revealed by the monkeys' ability to match a dynamic face to a complex tone or a black-and-white checkerboard to a pure tone, presumably based on duration and/or onset-offset synchrony. Together, these results suggest that prenatal ethanol exposure negatively affects a specific domain of audiovisual integration. This deficit is confined to the integration of information that is presented by the face and the voice and does not affect more elementary aspects of sensory integration.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25470725</pmid><doi>10.1371/journal.pone.0114100</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-12, Vol.9 (12), p.e114100-e114100 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1629929538 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alcohol use Alcohols Animals Behavior, Animal Biology and Life Sciences Cercopithecus aethiops Children Chlorocebus Cognition Cortex (frontal) Cortex (somatosensory) Disease Models, Animal Ethanol Exposure Face Face - physiology Female Fetal Alcohol Spectrum Disorders - pathology Fetal Alcohol Spectrum Disorders - veterinary Fetal alcohol syndrome Gestation Macaca mulatta Male Matching Medicine and Health Sciences Monkeys Pregnancy Pregnant women Prenatal experience Sensory integration Social behavior Social interactions Stimuli Vocalization, Animal - physiology |
| title | A deficit in face-voice integration in developing vervet monkeys exposed to ethanol during gestation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T05%3A36%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20deficit%20in%20face-voice%20integration%20in%20developing%20vervet%20monkeys%20exposed%20to%20ethanol%20during%20gestation&rft.jtitle=PloS%20one&rft.au=Zangenehpour,%20Shahin&rft.date=2014-12-03&rft.volume=9&rft.issue=12&rft.spage=e114100&rft.epage=e114100&rft.pages=e114100-e114100&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0114100&rft_dat=%3Cgale_plos_%3EA416969224%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1629929538&rft_id=info:pmid/25470725&rft_galeid=A416969224&rft_doaj_id=oai_doaj_org_article_e60aaf9f3b9649a9ab84bfa8d5749815&rfr_iscdi=true |