Effect of gold nanoparticle on structure and fluidity of lipid membrane
This paper deals with the effect of different size gold nanoparticles on the fluidity of lipid membrane at different regions of the bilayer. To investigate this, we have considered significantly large bilayer leaflets and incorporated only one nanoparticle each time, which was subjected to all atomi...
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| Veröffentlicht in: | PloS one 2014-12, Vol.9 (12), p.e114152-e114152 |
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| description | This paper deals with the effect of different size gold nanoparticles on the fluidity of lipid membrane at different regions of the bilayer. To investigate this, we have considered significantly large bilayer leaflets and incorporated only one nanoparticle each time, which was subjected to all atomistic molecular dynamics simulations. We have observed that, lipid molecules located near to the gold nanoparticle interact directly with it, which results in deformation of lipid structure and slower dynamics of lipid molecules. However, lipid molecules far away from the interaction site of the nanoparticle get perturbed, which gives rise to increase in local ordering of the lipid domains and decrease in fluidity. The bilayer thickness and area per head group in this region also get altered. Similar trend, but with different magnitude is also observed when different size nanoparticle interact with the bilayer. |
| doi_str_mv | 10.1371/journal.pone.0114152 |
| format | Article |
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To investigate this, we have considered significantly large bilayer leaflets and incorporated only one nanoparticle each time, which was subjected to all atomistic molecular dynamics simulations. We have observed that, lipid molecules located near to the gold nanoparticle interact directly with it, which results in deformation of lipid structure and slower dynamics of lipid molecules. However, lipid molecules far away from the interaction site of the nanoparticle get perturbed, which gives rise to increase in local ordering of the lipid domains and decrease in fluidity. The bilayer thickness and area per head group in this region also get altered. Similar trend, but with different magnitude is also observed when different size nanoparticle interact with the bilayer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0114152</identifier><identifier>PMID: 25469786</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Deformation ; Engineering and Technology ; Fluidity ; Gold ; Gold - chemistry ; Lipid Bilayers - chemistry ; Lipid Bilayers - metabolism ; Lipid structure ; Membrane Fluidity - drug effects ; Membrane lipids ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - toxicity ; Molecular chains ; Molecular dynamics ; Molecular Dynamics Simulation ; Molecular structure ; Nanoparticles ; Particle Size ; Phase Transition ; Phospholipids ; Transition Temperature ; Viscosity</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e114152-e114152</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Mhashal, Roy. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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To investigate this, we have considered significantly large bilayer leaflets and incorporated only one nanoparticle each time, which was subjected to all atomistic molecular dynamics simulations. We have observed that, lipid molecules located near to the gold nanoparticle interact directly with it, which results in deformation of lipid structure and slower dynamics of lipid molecules. However, lipid molecules far away from the interaction site of the nanoparticle get perturbed, which gives rise to increase in local ordering of the lipid domains and decrease in fluidity. The bilayer thickness and area per head group in this region also get altered. Similar trend, but with different magnitude is also observed when different size nanoparticle interact with the bilayer.</description><subject>Biology and Life Sciences</subject><subject>Deformation</subject><subject>Engineering and Technology</subject><subject>Fluidity</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Lipid Bilayers - chemistry</subject><subject>Lipid Bilayers - metabolism</subject><subject>Lipid structure</subject><subject>Membrane Fluidity - drug effects</subject><subject>Membrane lipids</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - toxicity</subject><subject>Molecular chains</subject><subject>Molecular dynamics</subject><subject>Molecular Dynamics Simulation</subject><subject>Molecular structure</subject><subject>Nanoparticles</subject><subject>Particle Size</subject><subject>Phase Transition</subject><subject>Phospholipids</subject><subject>Transition Temperature</subject><subject>Viscosity</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkktr3DAUhU1paZJp_0FpDYXSLmaqt61NIYQ0HQgE-toKWZZmNMjWVJJL8-8jd5wwLlkULSzk7x7de3SK4hUEK4gr-HHnh9BLt9r7Xq8AhARS9KQ4hRyjJUMAPz3anxRnMe4AoLhm7HlxgihhvKrZaXF1aYxWqfSm3HjXlr3s_V6GZJXTpe_LmMKg0hB0Kfu2NG6wrU23I-7s3rZlp7smyF6_KJ4Z6aJ-OX0XxY_Pl98vviyvb67WF-fXS8U4SsuKggYiwqWEhjQcwwbLRiPdtJhiLTHAuq4pa1jNIFAckloZSbVugcKtpAYvijcH3b3zUUweRAEZ4hzlBTOxPhCtlzuxD7aT4VZ4acXfAx82YppPqEoaRBvECMDE0NwPM5ATiShGGvAqa32abhuaTrdK9ylINxOd_-ntVmz8b0EQpSCrLor3k0DwvwYdk-hsVNq5bJkfxr4xQRUncOz77T_o49NN1EbmAWxvfL5XjaLinEDGs8uYZWr1CJVXqzurcmCMzeezgg-zgswk_Sdt5BCjWH_7-v_szc85--6I3Wrp0jZ6NyTr-zgHyQFUwccYtHkwGQIx5v3eDTHmXUx5z2Wvjx_ooeg-4PgOHYH5mg</recordid><startdate>20141203</startdate><enddate>20141203</enddate><creator>Mhashal, Anil R</creator><creator>Roy, Sudip</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141203</creationdate><title>Effect of gold nanoparticle on structure and fluidity of lipid membrane</title><author>Mhashal, Anil R ; Roy, Sudip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-750b1249aa1f4b931b3abe2ebd353ea303e8856b68610c9148cfa5eed0c3da5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biology and Life Sciences</topic><topic>Deformation</topic><topic>Engineering and Technology</topic><topic>Fluidity</topic><topic>Gold</topic><topic>Gold - 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To investigate this, we have considered significantly large bilayer leaflets and incorporated only one nanoparticle each time, which was subjected to all atomistic molecular dynamics simulations. We have observed that, lipid molecules located near to the gold nanoparticle interact directly with it, which results in deformation of lipid structure and slower dynamics of lipid molecules. However, lipid molecules far away from the interaction site of the nanoparticle get perturbed, which gives rise to increase in local ordering of the lipid domains and decrease in fluidity. The bilayer thickness and area per head group in this region also get altered. Similar trend, but with different magnitude is also observed when different size nanoparticle interact with the bilayer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25469786</pmid><doi>10.1371/journal.pone.0114152</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Deformation Engineering and Technology Fluidity Gold Gold - chemistry Lipid Bilayers - chemistry Lipid Bilayers - metabolism Lipid structure Membrane Fluidity - drug effects Membrane lipids Metal Nanoparticles - chemistry Metal Nanoparticles - toxicity Molecular chains Molecular dynamics Molecular Dynamics Simulation Molecular structure Nanoparticles Particle Size Phase Transition Phospholipids Transition Temperature Viscosity |
| title | Effect of gold nanoparticle on structure and fluidity of lipid membrane |
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