A novel in vivo model of focal light emitting diode-induced cone-photoreceptor phototoxicity: neuroprotection afforded by brimonidine, BDNF, PEDF or bFGF

We have investigated the effects of light-emitting diode (LED)-induced phototoxicity (LIP) on cone-photoreceptors and their protection with brimonidine (BMD), brain-derived neurotrophic factor (BDNF), pigment epithelium-derived factor (PEDF), ciliary neurotrophic factor (CNTF) or basic fibroblast gr...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e113798-e113798
Hauptverfasser:	Ortín-Martínez, Arturo, Valiente-Soriano, Francisco Javier, García-Ayuso, Diego, Alarcón-Martínez, Luis, Jiménez-López, Manuel, Bernal-Garro, José Manuel, Nieto-López, Leticia, Nadal-Nicolás, Francisco Manuel, Villegas-Pérez, María Paz, Wheeler, Larry A, Vidal-Sanz, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone mineral density Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - pharmacology Brimonidine Brimonidine Tartrate Cell Survival - drug effects Cell Survival - radiation effects Ciliary neurotrophic factor Circularity Cones Cornea Cross sections Dark adaptation Degeneration Disease Models, Animal Electronic components Electronics Epithelium Eye Proteins - pharmacology Female Fibroblast growth factor Fibroblast growth factor 2 Fibroblast Growth Factor 2 - pharmacology Fibroblast growth factors LEDs Light - adverse effects Light effects Light emitting diodes Medicine and Health Sciences Nerve Growth Factors - pharmacology Neurodegeneration Neuroprotection Neuroprotective Agents - pharmacology Optical Coherence Tomography Photoreception Photoreceptors Phototoxicity Pigment epithelium-derived factor Quinoxalines - pharmacology Rats, Sprague-Dawley Retina Retinal Cone Photoreceptor Cells - drug effects Retinal Cone Photoreceptor Cells - pathology Retinal Cone Photoreceptor Cells - radiation effects Retinal degeneration Rods Serpins - pharmacology Time Factors Tomography, Optical Coherence
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