Identification of tumor endothelial cells with high aldehyde dehydrogenase activity and a highly angiogenic phenotype

Tumor blood vessels play an important role in tumor progression and metastasis. It has been reported that tumor endothelial cells (TECs) exhibit highly angiogenic phenotypes compared with those of normal endothelial cells (NECs). TECs show higher proliferative and migratory abilities than those NECs...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e113910-e113910
Hauptverfasser:	Ohmura-Kakutani, Hitomi, Akiyama, Kosuke, Maishi, Nako, Ohga, Noritaka, Hida, Yasuhiro, Kawamoto, Taisuke, Iida, Junichiro, Shindoh, Masanobu, Tsuchiya, Kunihiko, Shinohara, Nobuo, Hida, Kyoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde dehydrogenase Aldehyde Dehydrogenase - analysis Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase - metabolism Aldehydes Angiogenesis Animal models Animals Biology and Life Sciences Blood Blood vessels CD90 antigen Cell Line Comparative analysis Dehydrogenase Dermis Endothelial cells Endothelial Cells - enzymology Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Flow cytometry Fluorescence Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Humans Medicine and Health Sciences Melanoma Melanoma - enzymology Melanoma - genetics Melanoma - pathology Metastases Mice, Nude Multidrug resistance Neovascularization, Pathologic - enzymology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Oral carcinoma Phenotypes RNA Stem cells Tubes Tumor Cells, Cultured Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor Receptor-2 - analysis Vascular Endothelial Growth Factor Receptor-2 - genetics Xenografts
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