Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis
Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma. Basal serum 25(OH)D concentrations were retrospect...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-12, Vol.9 (12), p.e112863-e112863 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e112863 |
|---|---|
| container_issue | 12 |
| container_start_page | e112863 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Bade, Benjamin Zdebik, Alexander Wagenpfeil, Stefan Gräber, Stefan Geisel, Jürgen Vogt, Thomas Reichrath, Jörg |
| description | Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma.
Basal serum 25(OH)D concentrations were retrospectively analyzed in a cohort of melanoma patients (n = 324) and healthy controls (n = 141). We tested the hypothesis that serum 25(OH)D concentrations are predictive of melanoma risk, thickness of primary melanomas, and overall survival (OS).
Median serum 25(OH)D concentrations were significantly lower (p = 0.004) in melanoma patients (median = 13.6 ng/ml) as compared to controls (median = 15.6 ng/ml). Primary tumors of patients with low serum 25(OH)D concentrations (20 ng/ml; median: 1.00 mm). Patients with 25(OH)D serum concentrations in the lowest quartile had inferior overall survival (median: 80 months) comparing with the highest quartile (median: 195 months; p = 0.049).
Our data support the concept that serum 25(OH)D concentrations are associated with risk and prognosis of melanoma. Whether normalizing serum 25(OH)D concentrations in these patients improves outcomes will require testing in future clinical trials. |
| doi_str_mv | 10.1371/journal.pone.0112863 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1629337527</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_0cdad9c6b3484d819e59f91af411ec2c</doaj_id><sourcerecordid>1629964375</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-cecc6274267ca6027c018905ebeca85c80f76202e8eaa3262d04d7d236b9cee03</originalsourceid><addsrcrecordid>eNptUsuO1DAQjBCIXRb-AIElLlwy-JE48QVpteKx0khc4Gx17M6Mh8Qe7GSG-XsyJLvaRZz8qq6ualeWvWZ0xUTFPuzCGD10q33wuKKM8VqKJ9klU4LnklPx9MH-InuR0o7SUtRSPs8ueFmIitL6Mjuuw5EkjGNPeJlvTzaG36eDG6B3nlhigjfohwiDCz4RiEggpWAcDGjJ0Q1b4ryJCGk6Rpd-kjZE0mMHPvRAwFsy-hYOk1ZoOiT7GDY-JJdeZs9a6BK-Wtar7MfnT99vvubrb19ub67XuSm5HHKDxkheFVxWBiTllaGsVrTEBg3UpalpW00GOdYIILjklha2slzIRhlEKq6ytzPvvgtJLzNLmkmuhKhKXk2I2xlhA-z0Proe4kkHcPrvRYgbDXFwpkNNjQWrjGxEURe2ZgpL1SoGbcEYGm4mro9Lt7Hp0c6j6x6RPn7xbqs34aALXqialxPB-4Ughl8jpkH3LhnspnliGGfdSk6fd4a--wf6f3fFjDIxpBSxvRfDqD7n6K5Kn3OklxxNZW8eGrkvuguO-ANWWMlb</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1629337527</pqid></control><display><type>article</type><title>Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Bade, Benjamin ; Zdebik, Alexander ; Wagenpfeil, Stefan ; Gräber, Stefan ; Geisel, Jürgen ; Vogt, Thomas ; Reichrath, Jörg</creator><contributor>Pizzo, Salvatore V.</contributor><creatorcontrib>Bade, Benjamin ; Zdebik, Alexander ; Wagenpfeil, Stefan ; Gräber, Stefan ; Geisel, Jürgen ; Vogt, Thomas ; Reichrath, Jörg ; Pizzo, Salvatore V.</creatorcontrib><description>Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma.
Basal serum 25(OH)D concentrations were retrospectively analyzed in a cohort of melanoma patients (n = 324) and healthy controls (n = 141). We tested the hypothesis that serum 25(OH)D concentrations are predictive of melanoma risk, thickness of primary melanomas, and overall survival (OS).
Median serum 25(OH)D concentrations were significantly lower (p = 0.004) in melanoma patients (median = 13.6 ng/ml) as compared to controls (median = 15.6 ng/ml). Primary tumors of patients with low serum 25(OH)D concentrations (<10 ng/ml) had significantly (p = 0.006) greater Breslow thickness (median: 1.9 mm) as compared to patients with higher levels (>20 ng/ml; median: 1.00 mm). Patients with 25(OH)D serum concentrations in the lowest quartile had inferior overall survival (median: 80 months) comparing with the highest quartile (median: 195 months; p = 0.049).
Our data support the concept that serum 25(OH)D concentrations are associated with risk and prognosis of melanoma. Whether normalizing serum 25(OH)D concentrations in these patients improves outcomes will require testing in future clinical trials.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112863</identifier><identifier>PMID: 25437008</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>25-Hydroxyvitamin D ; Adolescent ; Adult ; Aged ; Aging - blood ; Cancer ; Case-Control Studies ; Clinical trials ; Female ; Humans ; Male ; Medical prognosis ; Medical research ; Medicine and Health Sciences ; Melanoma ; Melanoma - blood ; Melanoma - diagnosis ; Melanoma - epidemiology ; Middle Aged ; Normalizing ; Patients ; Prognosis ; Retrospective Studies ; Risk ; Survival ; Tumors ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Young Adult</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e112863-e112863</ispartof><rights>2014 Bade et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Bade et al 2014 Bade et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-cecc6274267ca6027c018905ebeca85c80f76202e8eaa3262d04d7d236b9cee03</citedby><cites>FETCH-LOGICAL-c526t-cecc6274267ca6027c018905ebeca85c80f76202e8eaa3262d04d7d236b9cee03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249825/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249825/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25437008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pizzo, Salvatore V.</contributor><creatorcontrib>Bade, Benjamin</creatorcontrib><creatorcontrib>Zdebik, Alexander</creatorcontrib><creatorcontrib>Wagenpfeil, Stefan</creatorcontrib><creatorcontrib>Gräber, Stefan</creatorcontrib><creatorcontrib>Geisel, Jürgen</creatorcontrib><creatorcontrib>Vogt, Thomas</creatorcontrib><creatorcontrib>Reichrath, Jörg</creatorcontrib><title>Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma.
Basal serum 25(OH)D concentrations were retrospectively analyzed in a cohort of melanoma patients (n = 324) and healthy controls (n = 141). We tested the hypothesis that serum 25(OH)D concentrations are predictive of melanoma risk, thickness of primary melanomas, and overall survival (OS).
Median serum 25(OH)D concentrations were significantly lower (p = 0.004) in melanoma patients (median = 13.6 ng/ml) as compared to controls (median = 15.6 ng/ml). Primary tumors of patients with low serum 25(OH)D concentrations (<10 ng/ml) had significantly (p = 0.006) greater Breslow thickness (median: 1.9 mm) as compared to patients with higher levels (>20 ng/ml; median: 1.00 mm). Patients with 25(OH)D serum concentrations in the lowest quartile had inferior overall survival (median: 80 months) comparing with the highest quartile (median: 195 months; p = 0.049).
Our data support the concept that serum 25(OH)D concentrations are associated with risk and prognosis of melanoma. Whether normalizing serum 25(OH)D concentrations in these patients improves outcomes will require testing in future clinical trials.</description><subject>25-Hydroxyvitamin D</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging - blood</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Clinical trials</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Melanoma</subject><subject>Melanoma - blood</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - epidemiology</subject><subject>Middle Aged</subject><subject>Normalizing</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Survival</subject><subject>Tumors</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUsuO1DAQjBCIXRb-AIElLlwy-JE48QVpteKx0khc4Gx17M6Mh8Qe7GSG-XsyJLvaRZz8qq6ualeWvWZ0xUTFPuzCGD10q33wuKKM8VqKJ9klU4LnklPx9MH-InuR0o7SUtRSPs8ueFmIitL6Mjuuw5EkjGNPeJlvTzaG36eDG6B3nlhigjfohwiDCz4RiEggpWAcDGjJ0Q1b4ryJCGk6Rpd-kjZE0mMHPvRAwFsy-hYOk1ZoOiT7GDY-JJdeZs9a6BK-Wtar7MfnT99vvubrb19ub67XuSm5HHKDxkheFVxWBiTllaGsVrTEBg3UpalpW00GOdYIILjklha2slzIRhlEKq6ytzPvvgtJLzNLmkmuhKhKXk2I2xlhA-z0Proe4kkHcPrvRYgbDXFwpkNNjQWrjGxEURe2ZgpL1SoGbcEYGm4mro9Lt7Hp0c6j6x6RPn7xbqs34aALXqialxPB-4Ughl8jpkH3LhnspnliGGfdSk6fd4a--wf6f3fFjDIxpBSxvRfDqD7n6K5Kn3OklxxNZW8eGrkvuguO-ANWWMlb</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Bade, Benjamin</creator><creator>Zdebik, Alexander</creator><creator>Wagenpfeil, Stefan</creator><creator>Gräber, Stefan</creator><creator>Geisel, Jürgen</creator><creator>Vogt, Thomas</creator><creator>Reichrath, Jörg</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141201</creationdate><title>Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis</title><author>Bade, Benjamin ; Zdebik, Alexander ; Wagenpfeil, Stefan ; Gräber, Stefan ; Geisel, Jürgen ; Vogt, Thomas ; Reichrath, Jörg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-cecc6274267ca6027c018905ebeca85c80f76202e8eaa3262d04d7d236b9cee03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging - blood</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Clinical trials</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Melanoma</topic><topic>Melanoma - blood</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - epidemiology</topic><topic>Middle Aged</topic><topic>Normalizing</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Survival</topic><topic>Tumors</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bade, Benjamin</creatorcontrib><creatorcontrib>Zdebik, Alexander</creatorcontrib><creatorcontrib>Wagenpfeil, Stefan</creatorcontrib><creatorcontrib>Gräber, Stefan</creatorcontrib><creatorcontrib>Geisel, Jürgen</creatorcontrib><creatorcontrib>Vogt, Thomas</creatorcontrib><creatorcontrib>Reichrath, Jörg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bade, Benjamin</au><au>Zdebik, Alexander</au><au>Wagenpfeil, Stefan</au><au>Gräber, Stefan</au><au>Geisel, Jürgen</au><au>Vogt, Thomas</au><au>Reichrath, Jörg</au><au>Pizzo, Salvatore V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>9</volume><issue>12</issue><spage>e112863</spage><epage>e112863</epage><pages>e112863-e112863</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma.
Basal serum 25(OH)D concentrations were retrospectively analyzed in a cohort of melanoma patients (n = 324) and healthy controls (n = 141). We tested the hypothesis that serum 25(OH)D concentrations are predictive of melanoma risk, thickness of primary melanomas, and overall survival (OS).
Median serum 25(OH)D concentrations were significantly lower (p = 0.004) in melanoma patients (median = 13.6 ng/ml) as compared to controls (median = 15.6 ng/ml). Primary tumors of patients with low serum 25(OH)D concentrations (<10 ng/ml) had significantly (p = 0.006) greater Breslow thickness (median: 1.9 mm) as compared to patients with higher levels (>20 ng/ml; median: 1.00 mm). Patients with 25(OH)D serum concentrations in the lowest quartile had inferior overall survival (median: 80 months) comparing with the highest quartile (median: 195 months; p = 0.049).
Our data support the concept that serum 25(OH)D concentrations are associated with risk and prognosis of melanoma. Whether normalizing serum 25(OH)D concentrations in these patients improves outcomes will require testing in future clinical trials.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25437008</pmid><doi>10.1371/journal.pone.0112863</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-12, Vol.9 (12), p.e112863-e112863 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1629337527 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 25-Hydroxyvitamin D Adolescent Adult Aged Aging - blood Cancer Case-Control Studies Clinical trials Female Humans Male Medical prognosis Medical research Medicine and Health Sciences Melanoma Melanoma - blood Melanoma - diagnosis Melanoma - epidemiology Middle Aged Normalizing Patients Prognosis Retrospective Studies Risk Survival Tumors Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Young Adult |
| title | Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T14%3A12%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20serum%2025-hydroxyvitamin%20d%20concentrations%20are%20associated%20with%20increased%20risk%20for%20melanoma%20and%20unfavourable%20prognosis&rft.jtitle=PloS%20one&rft.au=Bade,%20Benjamin&rft.date=2014-12-01&rft.volume=9&rft.issue=12&rft.spage=e112863&rft.epage=e112863&rft.pages=e112863-e112863&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0112863&rft_dat=%3Cproquest_plos_%3E1629964375%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1629337527&rft_id=info:pmid/25437008&rft_doaj_id=oai_doaj_org_article_0cdad9c6b3484d819e59f91af411ec2c&rfr_iscdi=true |