Alginate microencapsulated hepatocytes optimised for transplantation in acute liver failure

Intraperitoneal transplantation of alginate-microencapsulated human hepatocytes is an attractive option for the management of acute liver failure (ALF) providing short-term support to allow native liver regeneration. The main aim of this study was to establish an optimised protocol for production of...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e113609
Hauptverfasser:	Jitraruch, Suttiruk, Dhawan, Anil, Hughes, Robin D, Filippi, Celine, Soong, Daniel, Philippeos, Christina, Lehec, Sharon C, Heaton, Nigel D, Longhi, Maria S, Mitry, Ragai R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates - chemistry Alginic acid Animals Ascitic fluid Biology and Life Sciences Blood & organ donations Cell activation Cell adhesion Cell culture Cell density Cell Survival Cells, Cultured Coculture Techniques Confocal microscopy D-Galactosamine Disease Models, Animal Encapsulation Galactosamine - adverse effects Glucuronic Acid - chemistry Good Manufacturing Practice Hepatocytes Hepatocytes - cytology Hepatocytes - transplantation Hexuronic Acids - chemistry Humans Immune response Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology Liver Liver diseases Liver failure Liver Failure, Acute - chemically induced Liver Failure, Acute - mortality Liver Failure, Acute - therapy Liver Regeneration Liver transplantation Liver transplants Male Medicine Medicine and Health Sciences Microscopy Microspheres Nanoparticles Peripheral blood mononuclear cells Polymerization Rats Rats, Sprague-Dawley Regeneration Rodents Studies Transplantation Transplantation, Heterologous Transplants & implants
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