RABEX-5 is upregulated and plays an oncogenic role in gastric cancer development by activating the VEGF signaling pathway

RABEX-5, a guanine-nucleotide exchange factor (GEF) for RAB-5, is implicated in tumorigenesis and in the development of certain human cancers. Here, we report that RABEX-5 promotes tumor growth and the metastatic ability of gastric cancer cells both in vitro and in vivo. Expression of RABEX-5 is sig...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e113891
Hauptverfasser:	Wang, Shuang, Lu, Aixia, Chen, Xiangming, Wei, Lin, Ding, Jiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Animal research Animals Apoptosis Cancer Cancer therapies Cell adhesion & migration Cell cycle Cell Cycle Checkpoints Cell Line, Tumor Cell Proliferation Chemotherapy Epidermal growth factor Female G1 phase Gastric cancer Gastric Mucosa - metabolism Gene Expression Regulation, Neoplastic Gene Silencing Guanine Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Humans Invasiveness Kinases Lymph nodes Male Medicine and Health Sciences Metastases Mice, Inbred BALB C Middle Aged Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Oncology Prostate cancer Signal Transduction Signaling Stomach - pathology Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Studies Surgery Tissues Tumorigenesis Tumors Up-Regulation Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Wound healing
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