Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype

Macrophages are myeloid cells that play an essential role in inflammation and host defense, regulating immune responses and maintaining tissue homeostasis. Depending on the microenvironment, macrophages can polarize to two distinct phenotypes. The M1 phenotype is activated by IFN-γ and bacterial pro...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e113441-e113441
Hauptverfasser:	Lopes, Rafael L, Borges, Thiago J, Araújo, Jessica F, Pinho, Nathana G, Bergamin, Letícia S, Battastini, Ana Maria O, Muraro, Stéfanie P, Souza, Ana Paula D, Zanin, Rafael F, Bonorino, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Arginase Arginase - immunology Arginase - metabolism Bacteria Bacterial Proteins - immunology Bacterial Proteins - metabolism beta-N-Acetylhexosaminidases - genetics beta-N-Acetylhexosaminidases - immunology beta-N-Acetylhexosaminidases - metabolism Biology and Life Sciences Biomedical research Bone marrow Cancer Cells, Cultured Cytokines Cytokines - immunology Cytokines - metabolism Dendritic cells DnaK protein Female Flow Cytometry Gene expression Gene Expression - immunology Genetic aspects Heat shock proteins Homeostasis HSP70 Heat-Shock Proteins - immunology HSP70 Heat-Shock Proteins - metabolism Immune response Immunology Immunosuppression Infections Inflammation Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - immunology Intercellular Signaling Peptides and Proteins - metabolism Interferon Interleukin 10 Interleukin 4 Interleukin-10 - immunology Interleukin-10 - metabolism Laboratories Lectins - genetics Lectins - immunology Lectins - metabolism Lipopolysaccharides - immunology Macrophage Activation - immunology Macrophages Macrophages - immunology Macrophages - metabolism Medicine and Health Sciences Melanoma Melanoma, Experimental - immunology Melanoma, Experimental - pathology Mice, Inbred BALB C Mice, Inbred C57BL Molecular biology Molecular Chaperones - immunology Molecular Chaperones - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - metabolism Myeloid cells Pathogens Peritoneum Pharmacy Phenotype Reverse Transcriptase Polymerase Chain Reaction Tuberculosis Tumors Virulence Virulence factors γ-Interferon
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