Hepatitis C virus induced endothelial inflammatory response depends on the functional expression of TNFα receptor subtype 2

In hepatitis C virus (HCV) infection, morbidity and mortality often result from extrahepatic disease manifestations. We provide evidence for a role of receptors of the innate immune system in virally induced inflammation of the endothelium in vitro and in vivo. Corresponding to the in vitro finding...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e113351-e113351
Hauptverfasser:	Pircher, Joachim, Czermak, Thomas, Merkle, Monika, Mannell, Hanna, Krötz, Florian, Ribeiro, Andrea, Vielhauer, Volker, Nadjiri, Jonathan, Gaitzsch, Erik, Niemeyer, Markus, Porubsky, Stefan, Gröne, Hermann-Josef, Wörnle, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Biology and Life Sciences Blood Blotting, Western Cancer Cell activation Cell migration Cell Proliferation - drug effects Cells, Cultured Cytokines Cytokines - genetics Cytokines - metabolism DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Endothelial cells Endothelial Cells - metabolism Endothelial Cells - virology Endothelium Experiments Extravasation Gene expression Gene Expression - drug effects Heart Hepacivirus - genetics Hepacivirus - physiology Hepatitis Hepatitis C Hepatitis C virus Host-Pathogen Interactions Humans Immune system Infections Infiltration Inflammation Inflammatory response Innate immunity Interferon Interferon-Induced Helicase, IFIH1 Leukocyte rolling Leukocyte Rolling - drug effects Leukocytes Medical research Medicine Medicine and Health Sciences Metastases Mice, Inbred C57BL Mice, Knockout Morbidity Poly (I:C) Poly I-C - pharmacology Polyinosinic:polycytidylic acid Receptors Receptors, Tumor Necrosis Factor, Type II - genetics Receptors, Tumor Necrosis Factor, Type II - metabolism Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA Interference Rodents Time Factors TLR3 protein Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - metabolism Toll-like receptors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Viral infections Viruses White blood cells
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