Establishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation

Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival and high recurrence rates. Despite evidence of graft-versus-myeloma (GvM) effects, the use of allogeneic hematopoietic stem cell transplantation (allo-SCT) remains controversial in MM. In the current study, we inv...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e113764-e113764
Hauptverfasser:	Binsfeld, Marilène, Beguin, Yves, Belle, Ludovic, Otjacques, Eléonore, Hannon, Muriel, Briquet, Alexandra, Heusschen, Roy, Drion, Pierre, Zilberberg, Jenny, Bogen, Bjarne, Baron, Frédéric, Caers, Jo
Format:	Artikel
Sprache:	eng
Schlagworte:	Allogeneic SCT Allografts Analysis Animal models Animals Antigens Autografts Biology and Life Sciences Bone marrow CD4 antigen CD8 antigen Cell survival Cytotoxicity Female Graft vs Tumor Effect - immunology Graft-versus-host reaction Graft-versus-myeloma Grafting GvHD Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Human health sciences Hématologie Immunological memory Immunology Immunotherapy Infiltration Laboratory animals Leukemia Luciferase Lymphocytes Lymphocytes T Major histocompatibility complex Male Medicine and Health Sciences Memory cells Mice Mice, Inbred BALB C MOPC315.BM Multiple myeloma Multiple Myeloma - immunology Multiple Myeloma - pathology Multiple Myeloma - therapy Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Paralysis Sciences de la santé humaine Spleen Stem cell transplantation Stem cells T cell receptors T cells T-cell receptor Transplantation Transplants & implants
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