Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy

Histone deacetylase inhibitors (HDACi) can induce human immunodeficiency virus (HIV) transcription from the HIV long terminal repeat (LTR). However, ex vivo and in vivo responses to HDACi are variable and the activity of HDACi in cells other than T-cells have not been well characterised. Here, we de...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e113341
Hauptverfasser:	Lu, Hao K, Gray, Lachlan R, Wightman, Fiona, Ellenberg, Paula, Khoury, Gabriela, Cheng, Wan-Jung, Mota, Talia M, Wesselingh, Steve, Gorry, Paul R, Cameron, Paul U, Churchill, Melissa J, Lewin, Sharon R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult Aged AIDS Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Benzamides - pharmacology Biology and life sciences Biomedical research Biotechnology CD4 antigen Cell Line Cell lines Chromatin Drug therapy Epithelial cells HeLa Cells Histone deacetylase Histone Deacetylase Inhibitors - pharmacology HIV HIV Infections - blood HIV Infections - drug therapy HIV Infections - virology HIV Long Terminal Repeat - drug effects Hospitals Human immunodeficiency virus Humans Hydroxamic Acids - pharmacology Immunological memory Immunology Indoles - pharmacology Infectious diseases Inhibitors Long terminal repeat Lymphocytes Lymphocytes T Medicine and health sciences Memory cells Observational Studies as Topic Panobinostat Patients Phylogeny Pyridines - pharmacology Studies T-Lymphocytes - drug effects T-Lymphocytes - virology tat Gene Products, Human Immunodeficiency Virus - pharmacology Tat protein Therapy Transcription Trichostatin A Viruses Vorinostat
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