Molecular confirmation of Bacillus Calmette Guerin vaccine related adverse events among Saudi Arabian children
Bacillus Calmette Guerin (BCG) is the only available vaccine for tuberculosis (TB). Low grade complications in healthy recipients and disseminated vaccine associated complications among immuno-suppressed individuals were noticed globally after administration. Recently a series of clinically suspecte...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-11, Vol.9 (11), p.e113472-e113472 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e113472 |
|---|---|
| container_issue | 11 |
| container_start_page | e113472 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Al-Hajoj, Sahal Memish, Ziad Abuljadayel, Naila AlHakeem, Raafat AlRabiah, Fahad Varghese, Bright |
| description | Bacillus Calmette Guerin (BCG) is the only available vaccine for tuberculosis (TB). Low grade complications in healthy recipients and disseminated vaccine associated complications among immuno-suppressed individuals were noticed globally after administration. Recently a series of clinically suspected BCG associated suppurative and non-suppurative lymphadenitis cases were reported from different regions of Saudi Arabia. However a molecular confirmative analysis was lacking to prove these claims.
During 2009-2010, 42 Mycobacterium bovis BCG suspected clinical isolates from children diagnosed with suppurative lymphadenitis from different provinces of the country were collected and subjected to 24 loci based MIRU-VNTR typing, spoligotyping and first line anti-TB drugs susceptibility testing.
Of the total 42 cases, 41 (97.6%) were Saudi nationals and particularly male (64.3%). Majority of the cases were aged below 6 months (83.3%) with a median of age 4 months. All the enrolled subjects showed left axillary mass which suppurated in a median of 4 months after vaccination. Among the study subjects, 1 (2.4%) case was reactive to HIV antigen and 2 (4.8%) case had severe combined immunodeficiency. Genotyping results showed that, 41 (97.6%) isolates were identical to the vaccine strain Danish 1331 and one to Tokyo 172-1. Phylogenetic analysis revealed all the Danish 1331 isolates in a single cluster.
Elevated proportion of suppurative lymphadenitis caused by M. bovis BCG reported in the country recently is majorly related to the vaccine strain Danish 1331. However lack of nationwide data on real magnitude of BCG related adverse events warrants population centric, long term future studies. |
| doi_str_mv | 10.1371/journal.pone.0113472 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1626171033</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_c04494170f56494096bd1f09cd7a87dc</doaj_id><sourcerecordid>3501855841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-c7e15ef6c8ced20d8e007afacbb6836abb7a780b9f0cdfb415e13b3ffa14ca9c3</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEoqXwDxBY4tLLLnbstZMLUlmVUqmIA3C2JvZ465VjL3ayEv-ebDetWoR88Mh-5p0PvVX1ltEl44p93KYxRwjLXYq4pIxxoepn1Slreb2QNeXPH8Un1atStpSueCPly-qkXgnaskacVvFbCmjGAJmYFJ3PPQw-RZIc-QzGhzAWsobQ4zAguRox-0j2YIyPSDIGGNASsHvMBQnuMQ6FQJ_ihvyA0XpykaHzEIm59cFmjK-rFw5CwTfzfVb9-nL5c_11cfP96np9cbMwq1oOC6OQrdBJ0xi0NbUNUqrAgek62XAJXadANbRrHTXWdWKCGe-4c8CEgdbws-r9UXcXUtHzqopmspZMMcr5RFwfCZtgq3fZ95D_6ARe3z2kvNGQB28CakOFaAVT1K3kFNBWdpY52hqroFH2UO3TXG3serRmWkOG8ET06U_0t3qT9lrUXAnOJoHzWSCn3yOWQfe-GAwBIqbxrm9FpyPbCf3wD_r_6cSRMjmVktE9NMOoPtjnPksf7KNn-0xp7x4P8pB07xf-F5JHxf0</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1626171033</pqid></control><display><type>article</type><title>Molecular confirmation of Bacillus Calmette Guerin vaccine related adverse events among Saudi Arabian children</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Al-Hajoj, Sahal ; Memish, Ziad ; Abuljadayel, Naila ; AlHakeem, Raafat ; AlRabiah, Fahad ; Varghese, Bright</creator><contributor>Cardona, Pere-Joan</contributor><creatorcontrib>Al-Hajoj, Sahal ; Memish, Ziad ; Abuljadayel, Naila ; AlHakeem, Raafat ; AlRabiah, Fahad ; Varghese, Bright ; Cardona, Pere-Joan</creatorcontrib><description>Bacillus Calmette Guerin (BCG) is the only available vaccine for tuberculosis (TB). Low grade complications in healthy recipients and disseminated vaccine associated complications among immuno-suppressed individuals were noticed globally after administration. Recently a series of clinically suspected BCG associated suppurative and non-suppurative lymphadenitis cases were reported from different regions of Saudi Arabia. However a molecular confirmative analysis was lacking to prove these claims.
During 2009-2010, 42 Mycobacterium bovis BCG suspected clinical isolates from children diagnosed with suppurative lymphadenitis from different provinces of the country were collected and subjected to 24 loci based MIRU-VNTR typing, spoligotyping and first line anti-TB drugs susceptibility testing.
Of the total 42 cases, 41 (97.6%) were Saudi nationals and particularly male (64.3%). Majority of the cases were aged below 6 months (83.3%) with a median of age 4 months. All the enrolled subjects showed left axillary mass which suppurated in a median of 4 months after vaccination. Among the study subjects, 1 (2.4%) case was reactive to HIV antigen and 2 (4.8%) case had severe combined immunodeficiency. Genotyping results showed that, 41 (97.6%) isolates were identical to the vaccine strain Danish 1331 and one to Tokyo 172-1. Phylogenetic analysis revealed all the Danish 1331 isolates in a single cluster.
Elevated proportion of suppurative lymphadenitis caused by M. bovis BCG reported in the country recently is majorly related to the vaccine strain Danish 1331. However lack of nationwide data on real magnitude of BCG related adverse events warrants population centric, long term future studies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0113472</identifier><identifier>PMID: 25409184</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Asthma ; Bacillus ; Bacillus Calmette-Guerin vaccine ; BCG ; BCG Vaccine - adverse effects ; BCG Vaccine - immunology ; Biology and Life Sciences ; Children ; Clinical isolates ; Cluster Analysis ; Complications ; Data collection ; Disease ; Disease prevention ; Drugs ; Epidemics ; Female ; Genetic Loci ; Genotype ; Genotyping ; HIV ; Hospitals ; Human immunodeficiency virus ; Humans ; Infant ; Infant, Newborn ; Infections ; Laboratories ; Lymphadenitis ; Lymphadenitis - epidemiology ; Lymphadenitis - etiology ; Male ; Medicine and Health Sciences ; Meningitis ; Mycobacterium bovis - classification ; Mycobacterium bovis - genetics ; Mycobacterium bovis - isolation & purification ; Patients ; Phylogeny ; Preventive medicine ; Saudi Arabia - epidemiology ; Severe combined immunodeficiency ; Severe Combined Immunodeficiency - epidemiology ; Severe Combined Immunodeficiency - etiology ; Spoligotyping ; Studies ; Tuberculosis ; Tuberculosis - prevention & control ; Vaccination ; Vaccination - adverse effects ; Vaccines</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e113472-e113472</ispartof><rights>2014 Al-Hajoj et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Al-Hajoj et al 2014 Al-Hajoj et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-c7e15ef6c8ced20d8e007afacbb6836abb7a780b9f0cdfb415e13b3ffa14ca9c3</citedby><cites>FETCH-LOGICAL-c526t-c7e15ef6c8ced20d8e007afacbb6836abb7a780b9f0cdfb415e13b3ffa14ca9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237431/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237431/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25409184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cardona, Pere-Joan</contributor><creatorcontrib>Al-Hajoj, Sahal</creatorcontrib><creatorcontrib>Memish, Ziad</creatorcontrib><creatorcontrib>Abuljadayel, Naila</creatorcontrib><creatorcontrib>AlHakeem, Raafat</creatorcontrib><creatorcontrib>AlRabiah, Fahad</creatorcontrib><creatorcontrib>Varghese, Bright</creatorcontrib><title>Molecular confirmation of Bacillus Calmette Guerin vaccine related adverse events among Saudi Arabian children</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Bacillus Calmette Guerin (BCG) is the only available vaccine for tuberculosis (TB). Low grade complications in healthy recipients and disseminated vaccine associated complications among immuno-suppressed individuals were noticed globally after administration. Recently a series of clinically suspected BCG associated suppurative and non-suppurative lymphadenitis cases were reported from different regions of Saudi Arabia. However a molecular confirmative analysis was lacking to prove these claims.
During 2009-2010, 42 Mycobacterium bovis BCG suspected clinical isolates from children diagnosed with suppurative lymphadenitis from different provinces of the country were collected and subjected to 24 loci based MIRU-VNTR typing, spoligotyping and first line anti-TB drugs susceptibility testing.
Of the total 42 cases, 41 (97.6%) were Saudi nationals and particularly male (64.3%). Majority of the cases were aged below 6 months (83.3%) with a median of age 4 months. All the enrolled subjects showed left axillary mass which suppurated in a median of 4 months after vaccination. Among the study subjects, 1 (2.4%) case was reactive to HIV antigen and 2 (4.8%) case had severe combined immunodeficiency. Genotyping results showed that, 41 (97.6%) isolates were identical to the vaccine strain Danish 1331 and one to Tokyo 172-1. Phylogenetic analysis revealed all the Danish 1331 isolates in a single cluster.
Elevated proportion of suppurative lymphadenitis caused by M. bovis BCG reported in the country recently is majorly related to the vaccine strain Danish 1331. However lack of nationwide data on real magnitude of BCG related adverse events warrants population centric, long term future studies.</description><subject>Asthma</subject><subject>Bacillus</subject><subject>Bacillus Calmette-Guerin vaccine</subject><subject>BCG</subject><subject>BCG Vaccine - adverse effects</subject><subject>BCG Vaccine - immunology</subject><subject>Biology and Life Sciences</subject><subject>Children</subject><subject>Clinical isolates</subject><subject>Cluster Analysis</subject><subject>Complications</subject><subject>Data collection</subject><subject>Disease</subject><subject>Disease prevention</subject><subject>Drugs</subject><subject>Epidemics</subject><subject>Female</subject><subject>Genetic Loci</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>HIV</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Lymphadenitis</subject><subject>Lymphadenitis - epidemiology</subject><subject>Lymphadenitis - etiology</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Meningitis</subject><subject>Mycobacterium bovis - classification</subject><subject>Mycobacterium bovis - genetics</subject><subject>Mycobacterium bovis - isolation & purification</subject><subject>Patients</subject><subject>Phylogeny</subject><subject>Preventive medicine</subject><subject>Saudi Arabia - epidemiology</subject><subject>Severe combined immunodeficiency</subject><subject>Severe Combined Immunodeficiency - epidemiology</subject><subject>Severe Combined Immunodeficiency - etiology</subject><subject>Spoligotyping</subject><subject>Studies</subject><subject>Tuberculosis</subject><subject>Tuberculosis - prevention & control</subject><subject>Vaccination</subject><subject>Vaccination - adverse effects</subject><subject>Vaccines</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEoqXwDxBY4tLLLnbstZMLUlmVUqmIA3C2JvZ465VjL3ayEv-ebDetWoR88Mh-5p0PvVX1ltEl44p93KYxRwjLXYq4pIxxoepn1Slreb2QNeXPH8Un1atStpSueCPly-qkXgnaskacVvFbCmjGAJmYFJ3PPQw-RZIc-QzGhzAWsobQ4zAguRox-0j2YIyPSDIGGNASsHvMBQnuMQ6FQJ_ihvyA0XpykaHzEIm59cFmjK-rFw5CwTfzfVb9-nL5c_11cfP96np9cbMwq1oOC6OQrdBJ0xi0NbUNUqrAgek62XAJXadANbRrHTXWdWKCGe-4c8CEgdbws-r9UXcXUtHzqopmspZMMcr5RFwfCZtgq3fZ95D_6ARe3z2kvNGQB28CakOFaAVT1K3kFNBWdpY52hqroFH2UO3TXG3serRmWkOG8ET06U_0t3qT9lrUXAnOJoHzWSCn3yOWQfe-GAwBIqbxrm9FpyPbCf3wD_r_6cSRMjmVktE9NMOoPtjnPksf7KNn-0xp7x4P8pB07xf-F5JHxf0</recordid><startdate>20141119</startdate><enddate>20141119</enddate><creator>Al-Hajoj, Sahal</creator><creator>Memish, Ziad</creator><creator>Abuljadayel, Naila</creator><creator>AlHakeem, Raafat</creator><creator>AlRabiah, Fahad</creator><creator>Varghese, Bright</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141119</creationdate><title>Molecular confirmation of Bacillus Calmette Guerin vaccine related adverse events among Saudi Arabian children</title><author>Al-Hajoj, Sahal ; Memish, Ziad ; Abuljadayel, Naila ; AlHakeem, Raafat ; AlRabiah, Fahad ; Varghese, Bright</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-c7e15ef6c8ced20d8e007afacbb6836abb7a780b9f0cdfb415e13b3ffa14ca9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Asthma</topic><topic>Bacillus</topic><topic>Bacillus Calmette-Guerin vaccine</topic><topic>BCG</topic><topic>BCG Vaccine - adverse effects</topic><topic>BCG Vaccine - immunology</topic><topic>Biology and Life Sciences</topic><topic>Children</topic><topic>Clinical isolates</topic><topic>Cluster Analysis</topic><topic>Complications</topic><topic>Data collection</topic><topic>Disease</topic><topic>Disease prevention</topic><topic>Drugs</topic><topic>Epidemics</topic><topic>Female</topic><topic>Genetic Loci</topic><topic>Genotype</topic><topic>Genotyping</topic><topic>HIV</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Lymphadenitis</topic><topic>Lymphadenitis - epidemiology</topic><topic>Lymphadenitis - etiology</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Meningitis</topic><topic>Mycobacterium bovis - classification</topic><topic>Mycobacterium bovis - genetics</topic><topic>Mycobacterium bovis - isolation & purification</topic><topic>Patients</topic><topic>Phylogeny</topic><topic>Preventive medicine</topic><topic>Saudi Arabia - epidemiology</topic><topic>Severe combined immunodeficiency</topic><topic>Severe Combined Immunodeficiency - epidemiology</topic><topic>Severe Combined Immunodeficiency - etiology</topic><topic>Spoligotyping</topic><topic>Studies</topic><topic>Tuberculosis</topic><topic>Tuberculosis - prevention & control</topic><topic>Vaccination</topic><topic>Vaccination - adverse effects</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Hajoj, Sahal</creatorcontrib><creatorcontrib>Memish, Ziad</creatorcontrib><creatorcontrib>Abuljadayel, Naila</creatorcontrib><creatorcontrib>AlHakeem, Raafat</creatorcontrib><creatorcontrib>AlRabiah, Fahad</creatorcontrib><creatorcontrib>Varghese, Bright</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Hajoj, Sahal</au><au>Memish, Ziad</au><au>Abuljadayel, Naila</au><au>AlHakeem, Raafat</au><au>AlRabiah, Fahad</au><au>Varghese, Bright</au><au>Cardona, Pere-Joan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular confirmation of Bacillus Calmette Guerin vaccine related adverse events among Saudi Arabian children</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-11-19</date><risdate>2014</risdate><volume>9</volume><issue>11</issue><spage>e113472</spage><epage>e113472</epage><pages>e113472-e113472</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Bacillus Calmette Guerin (BCG) is the only available vaccine for tuberculosis (TB). Low grade complications in healthy recipients and disseminated vaccine associated complications among immuno-suppressed individuals were noticed globally after administration. Recently a series of clinically suspected BCG associated suppurative and non-suppurative lymphadenitis cases were reported from different regions of Saudi Arabia. However a molecular confirmative analysis was lacking to prove these claims.
During 2009-2010, 42 Mycobacterium bovis BCG suspected clinical isolates from children diagnosed with suppurative lymphadenitis from different provinces of the country were collected and subjected to 24 loci based MIRU-VNTR typing, spoligotyping and first line anti-TB drugs susceptibility testing.
Of the total 42 cases, 41 (97.6%) were Saudi nationals and particularly male (64.3%). Majority of the cases were aged below 6 months (83.3%) with a median of age 4 months. All the enrolled subjects showed left axillary mass which suppurated in a median of 4 months after vaccination. Among the study subjects, 1 (2.4%) case was reactive to HIV antigen and 2 (4.8%) case had severe combined immunodeficiency. Genotyping results showed that, 41 (97.6%) isolates were identical to the vaccine strain Danish 1331 and one to Tokyo 172-1. Phylogenetic analysis revealed all the Danish 1331 isolates in a single cluster.
Elevated proportion of suppurative lymphadenitis caused by M. bovis BCG reported in the country recently is majorly related to the vaccine strain Danish 1331. However lack of nationwide data on real magnitude of BCG related adverse events warrants population centric, long term future studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25409184</pmid><doi>10.1371/journal.pone.0113472</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-11, Vol.9 (11), p.e113472-e113472 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1626171033 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Asthma Bacillus Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - adverse effects BCG Vaccine - immunology Biology and Life Sciences Children Clinical isolates Cluster Analysis Complications Data collection Disease Disease prevention Drugs Epidemics Female Genetic Loci Genotype Genotyping HIV Hospitals Human immunodeficiency virus Humans Infant Infant, Newborn Infections Laboratories Lymphadenitis Lymphadenitis - epidemiology Lymphadenitis - etiology Male Medicine and Health Sciences Meningitis Mycobacterium bovis - classification Mycobacterium bovis - genetics Mycobacterium bovis - isolation & purification Patients Phylogeny Preventive medicine Saudi Arabia - epidemiology Severe combined immunodeficiency Severe Combined Immunodeficiency - epidemiology Severe Combined Immunodeficiency - etiology Spoligotyping Studies Tuberculosis Tuberculosis - prevention & control Vaccination Vaccination - adverse effects Vaccines |
| title | Molecular confirmation of Bacillus Calmette Guerin vaccine related adverse events among Saudi Arabian children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T12%3A21%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20confirmation%20of%20Bacillus%20Calmette%20Guerin%20vaccine%20related%20adverse%20events%20among%20Saudi%20Arabian%20children&rft.jtitle=PloS%20one&rft.au=Al-Hajoj,%20Sahal&rft.date=2014-11-19&rft.volume=9&rft.issue=11&rft.spage=e113472&rft.epage=e113472&rft.pages=e113472-e113472&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0113472&rft_dat=%3Cproquest_plos_%3E3501855841%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1626171033&rft_id=info:pmid/25409184&rft_doaj_id=oai_doaj_org_article_c04494170f56494096bd1f09cd7a87dc&rfr_iscdi=true |