Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia

Eclampsia, defined as unexplained seizure in a woman with preeclampsia, is a life-threatening complication of pregnancy with unclear etiology. Magnesium sulfate (MgSO4) is the leading eclamptic seizure prophylactic, yet its mechanism of action remains unclear. Here, we hypothesized severe preeclamps...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e113670
Hauptverfasser:	Johnson, Abbie Chapman, Tremble, Sarah M, Chan, Siu-Lung, Moseley, Janae, LaMarca, Babbette, Nagle, Keith J, Cipolla, Marilyn J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-brain barrier Blood-Brain Barrier - metabolism Brain - metabolism Brain Edema - etiology Brain Edema - prevention & control Cholesterol Convulsants - therapeutic use Diet, High-Fat Disease Models, Animal Disease Susceptibility Eclampsia Eclampsia - prevention & control Edema Etiology Female Fetuses Fluorescein High cholesterol diet Hypertension Inflammation Inflammation - prevention & control Ischemia Laboratory animals Magnesium Magnesium sulfate Magnesium Sulfate - pharmacology Magnesium Sulfate - therapeutic use Medicine Medicine and Health Sciences Membrane permeability Metabolism Microglia Microglia - drug effects Microglia - physiology Oxidative stress Oxidative Stress - drug effects Pentylenetetrazole Pentylenetetrazole - therapeutic use Perfusion Permeability Permeability - drug effects Pharmacology Physical Sciences Physiology Placenta Pre-eclampsia Pre-Eclampsia - pathology Preeclampsia Pregnancy Rats Rats, Sprague-Dawley Rodents Seizing Seizures - complications Seizures - drug therapy Seizures - physiopathology Severity of Illness Index Sodium Sulfates
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