Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target

The human pathogen Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis (TB), a disease with high worldwide mortality rates. Current treatment programs are under significant threat from multi-drug and extensively-drug resistant strains of M. tuberculosis, and it is essential t...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e113568-e113568
Hauptverfasser:	Gurcha, Sudagar S, Usha, Veeraraghavan, Cox, Jonathan A G, Fütterer, Klaus, Abrahams, Katherine A, Bhatt, Apoorva, Alderwick, Luke J, Reynolds, Robert C, Loman, Nicholas J, Nataraj, VijayaShankar, Alemparte, Carlos, Barros, David, Lloyd, Adrian J, Ballell, Lluis, Hobrath, Judith V, Besra, Gurdyal S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Aspartate-tRNA ligase Aspartate-tRNA Ligase - chemistry Aspartate-tRNA Ligase - genetics Aspartate-tRNA Ligase - metabolism Bacillus Calmette-Guerin vaccine BCG Biology and Life Sciences Cell culture Cloning, Molecular Crystal structure Crystallography, X-Ray Deoxyribonucleic acid Dimerization DNA Drug resistance Drug Resistance, Multiple, Bacterial - drug effects E coli Enzymes Escherichia coli Gene polymorphism Gene sequencing Genetic testing Genomes High-throughput screening Humans Impact analysis Inhibitors Kinetics Lung diseases Maximum likelihood method Medical treatment Medicine and Health Sciences Microbial Sensitivity Tests Minimum inhibitory concentration Molecular Sequence Data Mutants Mycobacterium bovis - drug effects Mycobacterium bovis - enzymology Mycobacterium smegmatis - drug effects Mycobacterium smegmatis - enzymology Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology Optimization Piperidines - chemistry Piperidines - pharmacology Piperidines - therapeutic use Polymorphism Polymorphism, Single Nucleotide Protein Binding Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - isolation & purification Resistant mutant Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Single-nucleotide polymorphism Structural analysis Thiazoles - chemistry Thiazoles - pharmacology Thiazoles - therapeutic use Transfer RNA tRNA Tuberculosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - pathology West Nile virus
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