Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity

Targeted radiotherapy of liver malignancies has found to be effective in selected patients. A key limiting factor of these therapies is the relatively low tolerance of the liver parenchyma to radiation. We sought to assess the preventive effects of a combined regimen of pentoxifylline (PTX), ursodeo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e112731
Hauptverfasser:	Seidensticker, Max, Seidensticker, Ricarda, Damm, Robert, Mohnike, Konrad, Pech, Maciej, Sangro, Bruno, Hass, Peter, Wust, Peter, Kropf, Siegfried, Gademann, Günther, Ricke, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Acids Aged Aged, 80 and over Background radiation Bone marrow Brachytherapy Brachytherapy - adverse effects Brachytherapy - methods Chemotherapy Clinical trials Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - radiotherapy Cytokines Data processing Dosimeters Dosimetry Drug dosages Drugs Enoxaparin - administration & dosage Feasibility studies Female Heparin Humans Liver Liver diseases Liver Neoplasms - radiotherapy Liver Neoplasms - secondary Low molecular weights Magnetic resonance Magnetic resonance imaging Male Medical imaging Medical research Medicine and Health Sciences Metastases Metastasis Middle Aged Molecular weight Neoplasm Metastasis NMR Nuclear magnetic resonance Parenchyma Patients Pediatrics Pentoxifylline - administration & dosage Prevention Prospective Studies Radiation Radiation effects Radiation injuries Radiation Injuries - prevention & control Radiation therapy Randomization Rodents Stem cells Toxicity Transplants & implants Ursodeoxycholic acid Ursodeoxycholic Acid - administration & dosage
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!