Protein profiling of preeclampsia placental tissues
Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylation...
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| creator | Shu, Chang Liu, Zitao Cui, Lifeng Wei, Chengguo Wang, Shuwen Tang, Jian Jenny Cui, Miao Lian, Guodong Li, Wei Liu, Xiufen Xu, Hongmei Jiang, Jing Lee, Peng Zhang, David Y He, Jin Ye, Fei |
| description | Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Using the Protein Pathway Array, 38 proteins in placental tissues were found to be differentially expressed between preterm preeclampsia and gestational age matched control, while 25 proteins were found to be expressed differentially between term preeclampsia and matched controls. Among these proteins, 16 proteins and their associated signaling pathways overlapped between preterm and term preeclampsia, suggesting the common pathogenesis of two subsets of disease. On the other hand, many proteins are uniquely altered in either preterm or term preeclampsia and correlated with severity of clinical symptoms and outcomes, therefore, providing molecular basis for these two subsets of preeclampsia. Furthermore, the expression levels of some of these proteins correlated with neonatal small for gestational age (PAI-1 and PAPP-A) and adverse outcomes (Flt-1) in women with preterm preeclampsia. These proteins could potentially be used as candidate biomarkers for predicting outcomes of preeclampsia. |
| doi_str_mv | 10.1371/journal.pone.0112890 |
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The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Using the Protein Pathway Array, 38 proteins in placental tissues were found to be differentially expressed between preterm preeclampsia and gestational age matched control, while 25 proteins were found to be expressed differentially between term preeclampsia and matched controls. Among these proteins, 16 proteins and their associated signaling pathways overlapped between preterm and term preeclampsia, suggesting the common pathogenesis of two subsets of disease. On the other hand, many proteins are uniquely altered in either preterm or term preeclampsia and correlated with severity of clinical symptoms and outcomes, therefore, providing molecular basis for these two subsets of preeclampsia. Furthermore, the expression levels of some of these proteins correlated with neonatal small for gestational age (PAI-1 and PAPP-A) and adverse outcomes (Flt-1) in women with preterm preeclampsia. These proteins could potentially be used as candidate biomarkers for predicting outcomes of preeclampsia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112890</identifier><identifier>PMID: 25392996</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Biomarkers ; Biomarkers - metabolism ; Birth weight ; Female ; Gastrointestinal surgery ; Gestational Age ; Gynecology ; Hospitals ; Humans ; Hypertension ; Medicine ; Medicine and Health Sciences ; Neonates ; Obstetrics ; Pathogenesis ; Pathology ; Placenta ; Placenta - metabolism ; Placenta - physiopathology ; Polyamide-imides ; Pre-eclampsia ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - metabolism ; Pre-Eclampsia - physiopathology ; Preeclampsia ; Pregnancy ; Pregnancy Proteins - biosynthesis ; Protein arrays ; Protein expression ; Proteins ; Signaling ; Small-for-gestational age ; Studies ; Tissues ; Vascular endothelial growth factor ; Womens health</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e112890-e112890</ispartof><rights>2014 Shu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Shu et al 2014 Shu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-138c797581fc4b6104e78c9d139fe580daa4ac7d9451bb6de6df0314933b0b7b3</citedby><cites>FETCH-LOGICAL-c526t-138c797581fc4b6104e78c9d139fe580daa4ac7d9451bb6de6df0314933b0b7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231077/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231077/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25392996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Buratti, Emanuele</contributor><creatorcontrib>Shu, Chang</creatorcontrib><creatorcontrib>Liu, Zitao</creatorcontrib><creatorcontrib>Cui, Lifeng</creatorcontrib><creatorcontrib>Wei, Chengguo</creatorcontrib><creatorcontrib>Wang, Shuwen</creatorcontrib><creatorcontrib>Tang, Jian Jenny</creatorcontrib><creatorcontrib>Cui, Miao</creatorcontrib><creatorcontrib>Lian, Guodong</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Liu, Xiufen</creatorcontrib><creatorcontrib>Xu, Hongmei</creatorcontrib><creatorcontrib>Jiang, Jing</creatorcontrib><creatorcontrib>Lee, Peng</creatorcontrib><creatorcontrib>Zhang, David Y</creatorcontrib><creatorcontrib>He, Jin</creatorcontrib><creatorcontrib>Ye, Fei</creatorcontrib><title>Protein profiling of preeclampsia placental tissues</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Using the Protein Pathway Array, 38 proteins in placental tissues were found to be differentially expressed between preterm preeclampsia and gestational age matched control, while 25 proteins were found to be expressed differentially between term preeclampsia and matched controls. Among these proteins, 16 proteins and their associated signaling pathways overlapped between preterm and term preeclampsia, suggesting the common pathogenesis of two subsets of disease. On the other hand, many proteins are uniquely altered in either preterm or term preeclampsia and correlated with severity of clinical symptoms and outcomes, therefore, providing molecular basis for these two subsets of preeclampsia. 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These proteins could potentially be used as candidate biomarkers for predicting outcomes of preeclampsia.</description><subject>Adult</subject><subject>Age</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Birth weight</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Gestational Age</subject><subject>Gynecology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Neonates</subject><subject>Obstetrics</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Placenta - physiopathology</subject><subject>Polyamide-imides</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - metabolism</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Proteins - biosynthesis</subject><subject>Protein arrays</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Signaling</subject><subject>Small-for-gestational age</subject><subject>Studies</subject><subject>Tissues</subject><subject>Vascular endothelial growth factor</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk2PFCEUJEbjrqv_wOgkXrzMyOPR0FxMzMaPTTbRg57Jg6ZHJkzTQo-J_96end7NrjEcgEdV8QqKsZfAN4Aa3u3yoQyUNmMewoYDiNbwR-wcDIq1Ehwf31ufsWe17jhvsFXqKTsTDRphjDpn-K3kKcRhNZbcxxSH7Sr38yYEn2g_1kirMZEPw0RpNcVaD6E-Z096SjW8WOYL9uPTx--XX9bXXz9fXX64XvtGqGkN2HptdNNC76VTwGXQrTcdoOlD0_KOSJLXnZENOKe6oLqeI0iD6LjTDi_Y65PumHK1i99qQQlp5oFiRlydEF2mnR1L3FP5YzNFe1PIZWupTNGnYB0n1FJBUM5IR7L1EARI1QrkcxFmrffLbQe3D93RcqH0QPThyRB_2m3-baVA4FrPAm8XgZJ_zc802X2sPqREQ8iHm74blGDMEfrmH-j_3ckTypdcawn9XTPA7TEDtyx7zIBdMjDTXt03cke6_XT8C1wOrqI</recordid><startdate>20141113</startdate><enddate>20141113</enddate><creator>Shu, Chang</creator><creator>Liu, Zitao</creator><creator>Cui, Lifeng</creator><creator>Wei, Chengguo</creator><creator>Wang, Shuwen</creator><creator>Tang, Jian Jenny</creator><creator>Cui, Miao</creator><creator>Lian, Guodong</creator><creator>Li, Wei</creator><creator>Liu, Xiufen</creator><creator>Xu, Hongmei</creator><creator>Jiang, Jing</creator><creator>Lee, Peng</creator><creator>Zhang, David Y</creator><creator>He, Jin</creator><creator>Ye, Fei</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141113</creationdate><title>Protein profiling of preeclampsia placental tissues</title><author>Shu, Chang ; Liu, Zitao ; Cui, Lifeng ; Wei, Chengguo ; Wang, Shuwen ; Tang, Jian Jenny ; Cui, Miao ; Lian, Guodong ; Li, Wei ; Liu, Xiufen ; Xu, Hongmei ; Jiang, Jing ; Lee, Peng ; Zhang, David Y ; He, Jin ; Ye, Fei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-138c797581fc4b6104e78c9d139fe580daa4ac7d9451bb6de6df0314933b0b7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age</topic><topic>Biomarkers</topic><topic>Biomarkers - 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The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Using the Protein Pathway Array, 38 proteins in placental tissues were found to be differentially expressed between preterm preeclampsia and gestational age matched control, while 25 proteins were found to be expressed differentially between term preeclampsia and matched controls. Among these proteins, 16 proteins and their associated signaling pathways overlapped between preterm and term preeclampsia, suggesting the common pathogenesis of two subsets of disease. On the other hand, many proteins are uniquely altered in either preterm or term preeclampsia and correlated with severity of clinical symptoms and outcomes, therefore, providing molecular basis for these two subsets of preeclampsia. Furthermore, the expression levels of some of these proteins correlated with neonatal small for gestational age (PAI-1 and PAPP-A) and adverse outcomes (Flt-1) in women with preterm preeclampsia. These proteins could potentially be used as candidate biomarkers for predicting outcomes of preeclampsia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25392996</pmid><doi>10.1371/journal.pone.0112890</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Biomarkers Biomarkers - metabolism Birth weight Female Gastrointestinal surgery Gestational Age Gynecology Hospitals Humans Hypertension Medicine Medicine and Health Sciences Neonates Obstetrics Pathogenesis Pathology Placenta Placenta - metabolism Placenta - physiopathology Polyamide-imides Pre-eclampsia Pre-Eclampsia - diagnosis Pre-Eclampsia - metabolism Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Pregnancy Proteins - biosynthesis Protein arrays Protein expression Proteins Signaling Small-for-gestational age Studies Tissues Vascular endothelial growth factor Womens health |
| title | Protein profiling of preeclampsia placental tissues |
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