Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts

The Notch ligand Delta-like 4 (Dll4) is highly expressed in vascular endothelium and has been shown to play a pivotal role in regulating tumor angiogenesis. Blockade of the Dll4-Notch pathway in preclinical cancer models has been associated with non-productive angiogenesis and reduced tumor growth....

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e112371-e112371
Hauptverfasser:	Miles, Kiersten Marie, Seshadri, Mukund, Ciamporcero, Eric, Adelaiye, Remi, Gillard, Bryan, Sotomayor, Paula, Attwood, Kristopher, Shen, Li, Conroy, Dylan, Kuhnert, Frank, Lalani, Alshad S, Thurston, Gavin, Pili, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal models Animals Antibodies, Monoclonal - administration & dosage Anticancer properties Antineoplastic Agents - chemistry Antitumor agents Breast cancer Cancer therapies Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - metabolism Cell Line, Tumor Clear cell-type renal cell carcinoma Endothelium Enzyme inhibitors Gene expression Growth inhibition Humans Indoles - administration & dosage Inhibition Inhibitors Intercellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Kidney cancer Kidney Neoplasms - drug therapy Kidney Neoplasms - metabolism Kinases Ligands Magnetic resonance Magnetic resonance imaging Male Medical prognosis Medicine and Health Sciences Membrane Proteins - antagonists & inhibitors Metastasis Mice Mice, SCID Neovascularization, Pathologic Notch protein Pathology Patients Perfusion Pharmaceuticals Protein-tyrosine kinase Proteins Pyrroles - administration & dosage Receptors, Vascular Endothelial Growth Factor - administration & dosage Recombinant Fusion Proteins - administration & dosage Regression analysis Resonance Signal Transduction Signaling Stem cells Tumors Tyrosine Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism Xenograft Model Antitumor Assays Xenografts
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