Serum inflammatory cytokine levels correlate with hand-foot-mouth disease severity: a nested serial case-control study
Hand-food-mouth disease (HFMD) cases can be fatal. These cases develop rapidly, and it is important to predict the severity of HFMD from mild to fatal and to identify risk factors for mild HFMD. The objective of this study was to correlate the levels of serum inflammatory cytokines with HFMD severit...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-11, Vol.9 (11), p.e112676-e112676 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e112676 |
|---|---|
| container_issue | 11 |
| container_start_page | e112676 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Duan, Guangcai Yang, Haiyan Shi, Lubin Sun, Wumei Sui, Meili Zhang, Rongguang Wang, Xinhong Wang, Fang Zhang, Weidong Xi, Yuanlin Fan, Qingtang |
| description | Hand-food-mouth disease (HFMD) cases can be fatal. These cases develop rapidly, and it is important to predict the severity of HFMD from mild to fatal and to identify risk factors for mild HFMD. The objective of this study was to correlate the levels of serum inflammatory cytokines with HFMD severity.
This study was designed as a nested serial case-control study. The data collected included general information, clinical symptoms and signs, laboratory findings and serum cytokine levels.
The levels of IL-4, IL-6, IL-10, TNF-α and IFN-γ in patients with severe HFMD were significantly higher than in mild patients during the 2nd to 5th day after disease onset. The levels of IL-4, IL-6, IL-10 and IFN-γ increased from the 2nd day to the 4th day and later decreased. The levels of TNF-α were high on the first two days and subsequently decreased. The changes of IL-10, TNF-α and IFN-γ in the controls were similar for all cases. The levels of IL-4, IL-6 and IL-17 in the controls were not significantly different with the progression of HFMD.
Our findings indicate that the IL-4, IL-6, IL-10, TNF-α and IFN-γ levels correlate with HFMD severity. |
| doi_str_mv | 10.1371/journal.pone.0112676 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1623314278</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A418552766</galeid><doaj_id>oai_doaj_org_article_9d27d22feba04285a695cafa02669004</doaj_id><sourcerecordid>A418552766</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-6e4ad3b27983796538d6f4b6cfa1ac96e5b0fe9db67558d7e0803acfe6b5cf3f3</originalsourceid><addsrcrecordid>eNqNk01v1DAQhiMEoqXwDxBEQkJwyOKPxEk4IFUVH5UqVaLA1ZrY410XJy62U9h_j7fdVl3UA8ohyfiZ1zPzaoriOSULylv67tzPYQK3uPATLgilTLTiQbFPe84qwQh_eOd7r3gS4zkhDe-EeFzssYb3lDZiv7g8wzCPpZ2Mg3GE5MO6VOvkf9oJS4eX6GKpfAjoIGH526ZVuYJJV8b7VI1-zv_aRoSIZcx0sGn9voRywphQ51Cw4EqVjyvlpxS8K2Oa9fpp8ciAi_hs-z4ovn_6-O3oS3Vy-vn46PCkUqJnqRJYg-YDa_uOt73I5Wth6kEoAxRUL7AZiMFeD6Jtmk63SDrCQRkUQ6MMN_ygeHmte-F8lNuRRUkF45zWrO0ycXxNaA_n8iLYEcJaerDyKuDDUkJIVjmUvWatZszgAKRmXQOibxQYIEyInpA6a33Y3jYPI2qFuWNwO6K7J5NdyaW_lDVjPWObYt5sBYL_NecZytFGhc7BhH6-qrvhdfaaZ_TVP-j93W2pJeQGsss-36s2ovKwpl3TsFaITC3uofKjcbTZNzQ2x3cS3u4kbLzFP2kJc4zy-Ozr_7OnP3bZ13fYFYJLq-jdnKyf4i5YX4Mq-BgDmtshUyI363EzDblZD7ldj5z24q5Bt0k3-8D_AnzmDMU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1623314278</pqid></control><display><type>article</type><title>Serum inflammatory cytokine levels correlate with hand-foot-mouth disease severity: a nested serial case-control study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Duan, Guangcai ; Yang, Haiyan ; Shi, Lubin ; Sun, Wumei ; Sui, Meili ; Zhang, Rongguang ; Wang, Xinhong ; Wang, Fang ; Zhang, Weidong ; Xi, Yuanlin ; Fan, Qingtang</creator><contributor>Ng, Lisa F. P.</contributor><creatorcontrib>Duan, Guangcai ; Yang, Haiyan ; Shi, Lubin ; Sun, Wumei ; Sui, Meili ; Zhang, Rongguang ; Wang, Xinhong ; Wang, Fang ; Zhang, Weidong ; Xi, Yuanlin ; Fan, Qingtang ; Ng, Lisa F. P.</creatorcontrib><description>Hand-food-mouth disease (HFMD) cases can be fatal. These cases develop rapidly, and it is important to predict the severity of HFMD from mild to fatal and to identify risk factors for mild HFMD. The objective of this study was to correlate the levels of serum inflammatory cytokines with HFMD severity.
This study was designed as a nested serial case-control study. The data collected included general information, clinical symptoms and signs, laboratory findings and serum cytokine levels.
The levels of IL-4, IL-6, IL-10, TNF-α and IFN-γ in patients with severe HFMD were significantly higher than in mild patients during the 2nd to 5th day after disease onset. The levels of IL-4, IL-6, IL-10 and IFN-γ increased from the 2nd day to the 4th day and later decreased. The levels of TNF-α were high on the first two days and subsequently decreased. The changes of IL-10, TNF-α and IFN-γ in the controls were similar for all cases. The levels of IL-4, IL-6 and IL-17 in the controls were not significantly different with the progression of HFMD.
Our findings indicate that the IL-4, IL-6, IL-10, TNF-α and IFN-γ levels correlate with HFMD severity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112676</identifier><identifier>PMID: 25391156</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antigens ; Biology and Life Sciences ; Biomarkers - blood ; Case-Control Studies ; Child, Preschool ; Children & youth ; Correlation analysis ; Coxsackievirus infections ; Cytokines ; Cytokines - blood ; Disease control ; Edema ; Encephalitis ; Epidemiology ; Female ; Hand, Foot and Mouth Disease - blood ; Hand, Foot and Mouth Disease - diagnosis ; Hospitals ; Humans ; Infant ; Inflammation ; Interferon ; Interleukin 10 ; Interleukin 17 ; Interleukin 4 ; Interleukin 6 ; Laboratories ; Male ; Medical research ; Medicine and health sciences ; Meningitis ; Nervous system ; Patients ; Prognosis ; Public health ; Risk analysis ; Risk factors ; Severity of Illness Index ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; γ-Interferon</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e112676-e112676</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Duan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Duan et al 2014 Duan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6e4ad3b27983796538d6f4b6cfa1ac96e5b0fe9db67558d7e0803acfe6b5cf3f3</citedby><cites>FETCH-LOGICAL-c692t-6e4ad3b27983796538d6f4b6cfa1ac96e5b0fe9db67558d7e0803acfe6b5cf3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229228/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229228/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25391156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ng, Lisa F. P.</contributor><creatorcontrib>Duan, Guangcai</creatorcontrib><creatorcontrib>Yang, Haiyan</creatorcontrib><creatorcontrib>Shi, Lubin</creatorcontrib><creatorcontrib>Sun, Wumei</creatorcontrib><creatorcontrib>Sui, Meili</creatorcontrib><creatorcontrib>Zhang, Rongguang</creatorcontrib><creatorcontrib>Wang, Xinhong</creatorcontrib><creatorcontrib>Wang, Fang</creatorcontrib><creatorcontrib>Zhang, Weidong</creatorcontrib><creatorcontrib>Xi, Yuanlin</creatorcontrib><creatorcontrib>Fan, Qingtang</creatorcontrib><title>Serum inflammatory cytokine levels correlate with hand-foot-mouth disease severity: a nested serial case-control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hand-food-mouth disease (HFMD) cases can be fatal. These cases develop rapidly, and it is important to predict the severity of HFMD from mild to fatal and to identify risk factors for mild HFMD. The objective of this study was to correlate the levels of serum inflammatory cytokines with HFMD severity.
This study was designed as a nested serial case-control study. The data collected included general information, clinical symptoms and signs, laboratory findings and serum cytokine levels.
The levels of IL-4, IL-6, IL-10, TNF-α and IFN-γ in patients with severe HFMD were significantly higher than in mild patients during the 2nd to 5th day after disease onset. The levels of IL-4, IL-6, IL-10 and IFN-γ increased from the 2nd day to the 4th day and later decreased. The levels of TNF-α were high on the first two days and subsequently decreased. The changes of IL-10, TNF-α and IFN-γ in the controls were similar for all cases. The levels of IL-4, IL-6 and IL-17 in the controls were not significantly different with the progression of HFMD.
Our findings indicate that the IL-4, IL-6, IL-10, TNF-α and IFN-γ levels correlate with HFMD severity.</description><subject>Antigens</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Correlation analysis</subject><subject>Coxsackievirus infections</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Disease control</subject><subject>Edema</subject><subject>Encephalitis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hand, Foot and Mouth Disease - blood</subject><subject>Hand, Foot and Mouth Disease - diagnosis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Inflammation</subject><subject>Interferon</subject><subject>Interleukin 10</subject><subject>Interleukin 17</subject><subject>Interleukin 4</subject><subject>Interleukin 6</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and health sciences</subject><subject>Meningitis</subject><subject>Nervous system</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Public health</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Severity of Illness Index</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>γ-Interferon</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQkJwyOKPxEk4IFUVH5UqVaLA1ZrY410XJy62U9h_j7fdVl3UA8ohyfiZ1zPzaoriOSULylv67tzPYQK3uPATLgilTLTiQbFPe84qwQh_eOd7r3gS4zkhDe-EeFzssYb3lDZiv7g8wzCPpZ2Mg3GE5MO6VOvkf9oJS4eX6GKpfAjoIGH526ZVuYJJV8b7VI1-zv_aRoSIZcx0sGn9voRywphQ51Cw4EqVjyvlpxS8K2Oa9fpp8ciAi_hs-z4ovn_6-O3oS3Vy-vn46PCkUqJnqRJYg-YDa_uOt73I5Wth6kEoAxRUL7AZiMFeD6Jtmk63SDrCQRkUQ6MMN_ygeHmte-F8lNuRRUkF45zWrO0ycXxNaA_n8iLYEcJaerDyKuDDUkJIVjmUvWatZszgAKRmXQOibxQYIEyInpA6a33Y3jYPI2qFuWNwO6K7J5NdyaW_lDVjPWObYt5sBYL_NecZytFGhc7BhH6-qrvhdfaaZ_TVP-j93W2pJeQGsss-36s2ovKwpl3TsFaITC3uofKjcbTZNzQ2x3cS3u4kbLzFP2kJc4zy-Ozr_7OnP3bZ13fYFYJLq-jdnKyf4i5YX4Mq-BgDmtshUyI363EzDblZD7ldj5z24q5Bt0k3-8D_AnzmDMU</recordid><startdate>20141112</startdate><enddate>20141112</enddate><creator>Duan, Guangcai</creator><creator>Yang, Haiyan</creator><creator>Shi, Lubin</creator><creator>Sun, Wumei</creator><creator>Sui, Meili</creator><creator>Zhang, Rongguang</creator><creator>Wang, Xinhong</creator><creator>Wang, Fang</creator><creator>Zhang, Weidong</creator><creator>Xi, Yuanlin</creator><creator>Fan, Qingtang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141112</creationdate><title>Serum inflammatory cytokine levels correlate with hand-foot-mouth disease severity: a nested serial case-control study</title><author>Duan, Guangcai ; Yang, Haiyan ; Shi, Lubin ; Sun, Wumei ; Sui, Meili ; Zhang, Rongguang ; Wang, Xinhong ; Wang, Fang ; Zhang, Weidong ; Xi, Yuanlin ; Fan, Qingtang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6e4ad3b27983796538d6f4b6cfa1ac96e5b0fe9db67558d7e0803acfe6b5cf3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antigens</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Correlation analysis</topic><topic>Coxsackievirus infections</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Disease control</topic><topic>Edema</topic><topic>Encephalitis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Hand, Foot and Mouth Disease - blood</topic><topic>Hand, Foot and Mouth Disease - diagnosis</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Inflammation</topic><topic>Interferon</topic><topic>Interleukin 10</topic><topic>Interleukin 17</topic><topic>Interleukin 4</topic><topic>Interleukin 6</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine and health sciences</topic><topic>Meningitis</topic><topic>Nervous system</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Public health</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Severity of Illness Index</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duan, Guangcai</creatorcontrib><creatorcontrib>Yang, Haiyan</creatorcontrib><creatorcontrib>Shi, Lubin</creatorcontrib><creatorcontrib>Sun, Wumei</creatorcontrib><creatorcontrib>Sui, Meili</creatorcontrib><creatorcontrib>Zhang, Rongguang</creatorcontrib><creatorcontrib>Wang, Xinhong</creatorcontrib><creatorcontrib>Wang, Fang</creatorcontrib><creatorcontrib>Zhang, Weidong</creatorcontrib><creatorcontrib>Xi, Yuanlin</creatorcontrib><creatorcontrib>Fan, Qingtang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duan, Guangcai</au><au>Yang, Haiyan</au><au>Shi, Lubin</au><au>Sun, Wumei</au><au>Sui, Meili</au><au>Zhang, Rongguang</au><au>Wang, Xinhong</au><au>Wang, Fang</au><au>Zhang, Weidong</au><au>Xi, Yuanlin</au><au>Fan, Qingtang</au><au>Ng, Lisa F. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum inflammatory cytokine levels correlate with hand-foot-mouth disease severity: a nested serial case-control study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-11-12</date><risdate>2014</risdate><volume>9</volume><issue>11</issue><spage>e112676</spage><epage>e112676</epage><pages>e112676-e112676</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Hand-food-mouth disease (HFMD) cases can be fatal. These cases develop rapidly, and it is important to predict the severity of HFMD from mild to fatal and to identify risk factors for mild HFMD. The objective of this study was to correlate the levels of serum inflammatory cytokines with HFMD severity.
This study was designed as a nested serial case-control study. The data collected included general information, clinical symptoms and signs, laboratory findings and serum cytokine levels.
The levels of IL-4, IL-6, IL-10, TNF-α and IFN-γ in patients with severe HFMD were significantly higher than in mild patients during the 2nd to 5th day after disease onset. The levels of IL-4, IL-6, IL-10 and IFN-γ increased from the 2nd day to the 4th day and later decreased. The levels of TNF-α were high on the first two days and subsequently decreased. The changes of IL-10, TNF-α and IFN-γ in the controls were similar for all cases. The levels of IL-4, IL-6 and IL-17 in the controls were not significantly different with the progression of HFMD.
Our findings indicate that the IL-4, IL-6, IL-10, TNF-α and IFN-γ levels correlate with HFMD severity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25391156</pmid><doi>10.1371/journal.pone.0112676</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-11, Vol.9 (11), p.e112676-e112676 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1623314278 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antigens Biology and Life Sciences Biomarkers - blood Case-Control Studies Child, Preschool Children & youth Correlation analysis Coxsackievirus infections Cytokines Cytokines - blood Disease control Edema Encephalitis Epidemiology Female Hand, Foot and Mouth Disease - blood Hand, Foot and Mouth Disease - diagnosis Hospitals Humans Infant Inflammation Interferon Interleukin 10 Interleukin 17 Interleukin 4 Interleukin 6 Laboratories Male Medical research Medicine and health sciences Meningitis Nervous system Patients Prognosis Public health Risk analysis Risk factors Severity of Illness Index Tumor necrosis factor Tumor necrosis factor-TNF Tumor necrosis factor-α γ-Interferon |
| title | Serum inflammatory cytokine levels correlate with hand-foot-mouth disease severity: a nested serial case-control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A34%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20inflammatory%20cytokine%20levels%20correlate%20with%20hand-foot-mouth%20disease%20severity:%20a%20nested%20serial%20case-control%20study&rft.jtitle=PloS%20one&rft.au=Duan,%20Guangcai&rft.date=2014-11-12&rft.volume=9&rft.issue=11&rft.spage=e112676&rft.epage=e112676&rft.pages=e112676-e112676&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0112676&rft_dat=%3Cgale_plos_%3EA418552766%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1623314278&rft_id=info:pmid/25391156&rft_galeid=A418552766&rft_doaj_id=oai_doaj_org_article_9d27d22feba04285a695cafa02669004&rfr_iscdi=true |