Relationship between neural rhythm generation disorders and physical disabilities in Parkinson's disease patients' walking
Walking is generated by the interaction between neural rhythmic and physical activities. In fact, Parkinson's disease (PD), which is an example of disease, causes not only neural rhythm generation disorders but also physical disabilities. However, the relationship between neural rhythm generati...
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| description | Walking is generated by the interaction between neural rhythmic and physical activities. In fact, Parkinson's disease (PD), which is an example of disease, causes not only neural rhythm generation disorders but also physical disabilities. However, the relationship between neural rhythm generation disorders and physical disabilities has not been determined. The aim of this study was to identify the mechanism of gait rhythm generation. In former research, neural rhythm generation disorders in PD patients' walking were characterized by stride intervals, which are more variable and fluctuate randomly. The variability and fluctuation property were quantified using the coefficient of variation (CV) and scaling exponent α. Conversely, because walking is a dynamic process, postural reflex disorder (PRD) is considered the best way to estimate physical disabilities in walking. Therefore, we classified the severity of PRD using CV and α. Specifically, PD patients and healthy elderly were classified into three groups: no-PRD, mild-PRD, and obvious-PRD. We compared the contributions of CV and α to the accuracy of this classification. In this study, 45 PD patients and 17 healthy elderly people walked 200 m. The severity of PRD was determined using the modified Hoehn-Yahr scale (mH-Y). People with mH-Y scores of 2.5 and 3 had mild-PRD and obvious-PRD, respectively. As a result, CV differentiated no-PRD from PRD, indicating the correlation between CV and PRD. Considering that PRD is independent of neural rhythm generation, this result suggests the existence of feedback process from physical activities to neural rhythmic activities. Moreover, α differentiated obvious-PRD from mild-PRD. Considering α reflects the intensity of interaction between factors, this result suggests the change of the interaction. Therefore, the interaction between neural rhythmic and physical activities is thought to plays an important role for gait rhythm generation. These characteristics have potential to evaluate the symptoms of PD. |
| doi_str_mv | 10.1371/journal.pone.0112952 |
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In fact, Parkinson's disease (PD), which is an example of disease, causes not only neural rhythm generation disorders but also physical disabilities. However, the relationship between neural rhythm generation disorders and physical disabilities has not been determined. The aim of this study was to identify the mechanism of gait rhythm generation. In former research, neural rhythm generation disorders in PD patients' walking were characterized by stride intervals, which are more variable and fluctuate randomly. The variability and fluctuation property were quantified using the coefficient of variation (CV) and scaling exponent α. Conversely, because walking is a dynamic process, postural reflex disorder (PRD) is considered the best way to estimate physical disabilities in walking. Therefore, we classified the severity of PRD using CV and α. Specifically, PD patients and healthy elderly were classified into three groups: no-PRD, mild-PRD, and obvious-PRD. We compared the contributions of CV and α to the accuracy of this classification. In this study, 45 PD patients and 17 healthy elderly people walked 200 m. The severity of PRD was determined using the modified Hoehn-Yahr scale (mH-Y). People with mH-Y scores of 2.5 and 3 had mild-PRD and obvious-PRD, respectively. As a result, CV differentiated no-PRD from PRD, indicating the correlation between CV and PRD. Considering that PRD is independent of neural rhythm generation, this result suggests the existence of feedback process from physical activities to neural rhythmic activities. Moreover, α differentiated obvious-PRD from mild-PRD. Considering α reflects the intensity of interaction between factors, this result suggests the change of the interaction. Therefore, the interaction between neural rhythmic and physical activities is thought to plays an important role for gait rhythm generation. These characteristics have potential to evaluate the symptoms of PD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112952</identifier><identifier>PMID: 25386639</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Biology and Life Sciences ; Coefficient of variation ; Disabilities ; Discriminant analysis ; Disorders ; Exercise ; Female ; Gait ; Gait - physiology ; Geriatrics ; Glucocorticoids ; Humans ; Male ; Medicine and Health Sciences ; Middle Aged ; Movement disorders ; Nervous System Diseases - etiology ; Neurodegenerative diseases ; Older people ; Parkinson Disease - complications ; Parkinson Disease - physiopathology ; Parkinson's disease ; Patients ; Physical Sciences ; Postural Balance ; Posture ; Reference Values ; Rehabilitation ; Rhythm ; Rhythms ; Scaling ; Systems science ; Time series ; Walking ; Walking - physiology</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e112952-e112952</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Ota et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Ota et al 2014 Ota et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c802t-ce4206447316e8d33c10adce745db53ff43672047507c44f08b2deb8efc2cb9d3</citedby><cites>FETCH-LOGICAL-c802t-ce4206447316e8d33c10adce745db53ff43672047507c44f08b2deb8efc2cb9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227866/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227866/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25386639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Arias-Carrion, Oscar</contributor><creatorcontrib>Ota, Leo</creatorcontrib><creatorcontrib>Uchitomi, Hirotaka</creatorcontrib><creatorcontrib>Ogawa, Ken-ichiro</creatorcontrib><creatorcontrib>Orimo, Satoshi</creatorcontrib><creatorcontrib>Miyake, Yoshihiro</creatorcontrib><title>Relationship between neural rhythm generation disorders and physical disabilities in Parkinson's disease patients' walking</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Walking is generated by the interaction between neural rhythmic and physical activities. In fact, Parkinson's disease (PD), which is an example of disease, causes not only neural rhythm generation disorders but also physical disabilities. However, the relationship between neural rhythm generation disorders and physical disabilities has not been determined. The aim of this study was to identify the mechanism of gait rhythm generation. In former research, neural rhythm generation disorders in PD patients' walking were characterized by stride intervals, which are more variable and fluctuate randomly. The variability and fluctuation property were quantified using the coefficient of variation (CV) and scaling exponent α. Conversely, because walking is a dynamic process, postural reflex disorder (PRD) is considered the best way to estimate physical disabilities in walking. Therefore, we classified the severity of PRD using CV and α. Specifically, PD patients and healthy elderly were classified into three groups: no-PRD, mild-PRD, and obvious-PRD. We compared the contributions of CV and α to the accuracy of this classification. In this study, 45 PD patients and 17 healthy elderly people walked 200 m. The severity of PRD was determined using the modified Hoehn-Yahr scale (mH-Y). People with mH-Y scores of 2.5 and 3 had mild-PRD and obvious-PRD, respectively. As a result, CV differentiated no-PRD from PRD, indicating the correlation between CV and PRD. Considering that PRD is independent of neural rhythm generation, this result suggests the existence of feedback process from physical activities to neural rhythmic activities. Moreover, α differentiated obvious-PRD from mild-PRD. Considering α reflects the intensity of interaction between factors, this result suggests the change of the interaction. Therefore, the interaction between neural rhythmic and physical activities is thought to plays an important role for gait rhythm generation. These characteristics have potential to evaluate the symptoms of PD.</description><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Coefficient of variation</subject><subject>Disabilities</subject><subject>Discriminant analysis</subject><subject>Disorders</subject><subject>Exercise</subject><subject>Female</subject><subject>Gait</subject><subject>Gait - physiology</subject><subject>Geriatrics</subject><subject>Glucocorticoids</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Nervous System Diseases - etiology</subject><subject>Neurodegenerative diseases</subject><subject>Older people</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Postural Balance</subject><subject>Posture</subject><subject>Reference Values</subject><subject>Rehabilitation</subject><subject>Rhythm</subject><subject>Rhythms</subject><subject>Scaling</subject><subject>Systems science</subject><subject>Time series</subject><subject>Walking</subject><subject>Walking - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ota, Leo</au><au>Uchitomi, Hirotaka</au><au>Ogawa, Ken-ichiro</au><au>Orimo, Satoshi</au><au>Miyake, Yoshihiro</au><au>Arias-Carrion, Oscar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between neural rhythm generation disorders and physical disabilities in Parkinson's disease patients' walking</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-11-11</date><risdate>2014</risdate><volume>9</volume><issue>11</issue><spage>e112952</spage><epage>e112952</epage><pages>e112952-e112952</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Walking is generated by the interaction between neural rhythmic and physical activities. In fact, Parkinson's disease (PD), which is an example of disease, causes not only neural rhythm generation disorders but also physical disabilities. However, the relationship between neural rhythm generation disorders and physical disabilities has not been determined. The aim of this study was to identify the mechanism of gait rhythm generation. In former research, neural rhythm generation disorders in PD patients' walking were characterized by stride intervals, which are more variable and fluctuate randomly. The variability and fluctuation property were quantified using the coefficient of variation (CV) and scaling exponent α. Conversely, because walking is a dynamic process, postural reflex disorder (PRD) is considered the best way to estimate physical disabilities in walking. Therefore, we classified the severity of PRD using CV and α. Specifically, PD patients and healthy elderly were classified into three groups: no-PRD, mild-PRD, and obvious-PRD. We compared the contributions of CV and α to the accuracy of this classification. In this study, 45 PD patients and 17 healthy elderly people walked 200 m. The severity of PRD was determined using the modified Hoehn-Yahr scale (mH-Y). People with mH-Y scores of 2.5 and 3 had mild-PRD and obvious-PRD, respectively. As a result, CV differentiated no-PRD from PRD, indicating the correlation between CV and PRD. Considering that PRD is independent of neural rhythm generation, this result suggests the existence of feedback process from physical activities to neural rhythmic activities. Moreover, α differentiated obvious-PRD from mild-PRD. Considering α reflects the intensity of interaction between factors, this result suggests the change of the interaction. Therefore, the interaction between neural rhythmic and physical activities is thought to plays an important role for gait rhythm generation. These characteristics have potential to evaluate the symptoms of PD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25386639</pmid><doi>10.1371/journal.pone.0112952</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biology and Life Sciences Coefficient of variation Disabilities Discriminant analysis Disorders Exercise Female Gait Gait - physiology Geriatrics Glucocorticoids Humans Male Medicine and Health Sciences Middle Aged Movement disorders Nervous System Diseases - etiology Neurodegenerative diseases Older people Parkinson Disease - complications Parkinson Disease - physiopathology Parkinson's disease Patients Physical Sciences Postural Balance Posture Reference Values Rehabilitation Rhythm Rhythms Scaling Systems science Time series Walking Walking - physiology |
| title | Relationship between neural rhythm generation disorders and physical disabilities in Parkinson's disease patients' walking |
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