Influence of Asian dust particles on immune adjuvant effects and airway inflammation in asthma model mice
An Asian dust storm (ADS) contains airborne particles that affect conditions such as asthma, but the mechanism of exacerbation is unclear. The objective of this study was to compare immune adjuvant effects and airway inflammation induced by airborne particles collected on ADS days and the original A...
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| Veröffentlicht in: | PloS one 2014-11, Vol.9 (11), p.e111831-e111831 |
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| creator | Kurai, Jun Watanabe, Masanari Tomita, Katsuyuki Sano, Hiroyuki Yamasaki, Hiroyuki Sano Akira Yamasaki, Akira Shimizu, Eiji |
| description | An Asian dust storm (ADS) contains airborne particles that affect conditions such as asthma, but the mechanism of exacerbation is unclear. The objective of this study was to compare immune adjuvant effects and airway inflammation induced by airborne particles collected on ADS days and the original ADS soil (CJ-1 soil) in asthma model mice.
Airborne particles were collected on ADS days in western Japan. NC/Nga mice were co-sensitized by intranasal instillation with ADS airborne particles and/or Dermatophagoides farinae (Df), and with CJ-1 soil and/or Df for 5 consecutive days. Df-sensitized mice were stimulated with Df challenge intranasally at 7 days after the last Df sensitization. At 24 hours after challenge, serum allergen specific antibody, differential leukocyte count and inflammatory cytokines in bronchoalveolar lavage fluid (BALF) were measured, and airway inflammation was examined histopathologically.
Co-sensitization with ADS airborne particles and Df increased the neutrophil and eosinophil counts in BALF. Augmentation of airway inflammation was also observed in peribronchiolar and perivascular lung areas. Df-specific serum IgE was significantly elevated by ADS airborne particles, but not by CJ-1 soil. Levels of interleukin (IL)-5, IL-13, IL-6, and macrophage inflammatory protein-2 were higher in BALF in mice treated with ADS airborne particles.
These results suggest that substances attached to ADS airborne particles that are not in the original ADS soil may play important roles in immune adjuvant effects and airway inflammation. |
| doi_str_mv | 10.1371/journal.pone.0111831 |
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Airborne particles were collected on ADS days in western Japan. NC/Nga mice were co-sensitized by intranasal instillation with ADS airborne particles and/or Dermatophagoides farinae (Df), and with CJ-1 soil and/or Df for 5 consecutive days. Df-sensitized mice were stimulated with Df challenge intranasally at 7 days after the last Df sensitization. At 24 hours after challenge, serum allergen specific antibody, differential leukocyte count and inflammatory cytokines in bronchoalveolar lavage fluid (BALF) were measured, and airway inflammation was examined histopathologically.
Co-sensitization with ADS airborne particles and Df increased the neutrophil and eosinophil counts in BALF. Augmentation of airway inflammation was also observed in peribronchiolar and perivascular lung areas. Df-specific serum IgE was significantly elevated by ADS airborne particles, but not by CJ-1 soil. Levels of interleukin (IL)-5, IL-13, IL-6, and macrophage inflammatory protein-2 were higher in BALF in mice treated with ADS airborne particles.
These results suggest that substances attached to ADS airborne particles that are not in the original ADS soil may play important roles in immune adjuvant effects and airway inflammation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0111831</identifier><identifier>PMID: 25386753</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Airborne particulates ; Allergens ; Allergies ; Aluminum ; Alveoli ; Analysis ; Animals ; Asthma ; Asthma - immunology ; Asthma - metabolism ; Augmentation ; Bronchoalveolar lavage ; Bronchoalveolar Lavage Fluid - immunology ; Bronchus ; Cytokines ; Cytokines - metabolism ; Disease Models, Animal ; Dust ; Dust - immunology ; Dust particles ; Dust storms ; Immunoglobulin E ; Inflammation ; Inflammation - immunology ; Inflammation - metabolism ; Interleukin ; Interleukin 13 ; Interleukin 6 ; Japan ; Leukocytes ; Leukocytes (eosinophilic) ; Lungs ; Macrophage inflammatory protein ; Macrophages ; Male ; Medicine ; Medicine and Health Sciences ; Mice ; Nitrates ; Outdoor air quality ; Particulates ; Respiratory System - immunology ; Respiratory System - metabolism ; Respiratory tract ; Respiratory tract diseases ; Rheumatology ; Sandstorms ; Soils ; Studies ; University faculty ; White blood cells</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e111831-e111831</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Kurai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Kurai et al 2014 Kurai et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-579510d7f37383f047f99aa6b92d40b60adbc8319181c7adc83348ed701a90c93</citedby><cites>FETCH-LOGICAL-c758t-579510d7f37383f047f99aa6b92d40b60adbc8319181c7adc83348ed701a90c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227670/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227670/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25386753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sun, Qinghua</contributor><creatorcontrib>Kurai, Jun</creatorcontrib><creatorcontrib>Watanabe, Masanari</creatorcontrib><creatorcontrib>Tomita, Katsuyuki</creatorcontrib><creatorcontrib>Sano, Hiroyuki</creatorcontrib><creatorcontrib>Yamasaki, Hiroyuki Sano Akira</creatorcontrib><creatorcontrib>Yamasaki, Akira</creatorcontrib><creatorcontrib>Shimizu, Eiji</creatorcontrib><title>Influence of Asian dust particles on immune adjuvant effects and airway inflammation in asthma model mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>An Asian dust storm (ADS) contains airborne particles that affect conditions such as asthma, but the mechanism of exacerbation is unclear. The objective of this study was to compare immune adjuvant effects and airway inflammation induced by airborne particles collected on ADS days and the original ADS soil (CJ-1 soil) in asthma model mice.
Airborne particles were collected on ADS days in western Japan. NC/Nga mice were co-sensitized by intranasal instillation with ADS airborne particles and/or Dermatophagoides farinae (Df), and with CJ-1 soil and/or Df for 5 consecutive days. Df-sensitized mice were stimulated with Df challenge intranasally at 7 days after the last Df sensitization. At 24 hours after challenge, serum allergen specific antibody, differential leukocyte count and inflammatory cytokines in bronchoalveolar lavage fluid (BALF) were measured, and airway inflammation was examined histopathologically.
Co-sensitization with ADS airborne particles and Df increased the neutrophil and eosinophil counts in BALF. Augmentation of airway inflammation was also observed in peribronchiolar and perivascular lung areas. Df-specific serum IgE was significantly elevated by ADS airborne particles, but not by CJ-1 soil. Levels of interleukin (IL)-5, IL-13, IL-6, and macrophage inflammatory protein-2 were higher in BALF in mice treated with ADS airborne particles.
These results suggest that substances attached to ADS airborne particles that are not in the original ADS soil may play important roles in immune adjuvant effects and airway inflammation.</description><subject>Airborne particulates</subject><subject>Allergens</subject><subject>Allergies</subject><subject>Aluminum</subject><subject>Alveoli</subject><subject>Analysis</subject><subject>Animals</subject><subject>Asthma</subject><subject>Asthma - immunology</subject><subject>Asthma - metabolism</subject><subject>Augmentation</subject><subject>Bronchoalveolar lavage</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Bronchus</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Dust</subject><subject>Dust - immunology</subject><subject>Dust particles</subject><subject>Dust storms</subject><subject>Immunoglobulin E</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Inflammation - 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immunology</topic><topic>Asthma - metabolism</topic><topic>Augmentation</topic><topic>Bronchoalveolar lavage</topic><topic>Bronchoalveolar Lavage Fluid - immunology</topic><topic>Bronchus</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Dust</topic><topic>Dust - immunology</topic><topic>Dust particles</topic><topic>Dust storms</topic><topic>Immunoglobulin E</topic><topic>Inflammation</topic><topic>Inflammation - immunology</topic><topic>Inflammation - metabolism</topic><topic>Interleukin</topic><topic>Interleukin 13</topic><topic>Interleukin 6</topic><topic>Japan</topic><topic>Leukocytes</topic><topic>Leukocytes (eosinophilic)</topic><topic>Lungs</topic><topic>Macrophage inflammatory protein</topic><topic>Macrophages</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Mice</topic><topic>Nitrates</topic><topic>Outdoor air quality</topic><topic>Particulates</topic><topic>Respiratory System - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurai, Jun</au><au>Watanabe, Masanari</au><au>Tomita, Katsuyuki</au><au>Sano, Hiroyuki</au><au>Yamasaki, Hiroyuki Sano Akira</au><au>Yamasaki, Akira</au><au>Shimizu, Eiji</au><au>Sun, Qinghua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Asian dust particles on immune adjuvant effects and airway inflammation in asthma model mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-11-11</date><risdate>2014</risdate><volume>9</volume><issue>11</issue><spage>e111831</spage><epage>e111831</epage><pages>e111831-e111831</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>An Asian dust storm (ADS) contains airborne particles that affect conditions such as asthma, but the mechanism of exacerbation is unclear. The objective of this study was to compare immune adjuvant effects and airway inflammation induced by airborne particles collected on ADS days and the original ADS soil (CJ-1 soil) in asthma model mice.
Airborne particles were collected on ADS days in western Japan. NC/Nga mice were co-sensitized by intranasal instillation with ADS airborne particles and/or Dermatophagoides farinae (Df), and with CJ-1 soil and/or Df for 5 consecutive days. Df-sensitized mice were stimulated with Df challenge intranasally at 7 days after the last Df sensitization. At 24 hours after challenge, serum allergen specific antibody, differential leukocyte count and inflammatory cytokines in bronchoalveolar lavage fluid (BALF) were measured, and airway inflammation was examined histopathologically.
Co-sensitization with ADS airborne particles and Df increased the neutrophil and eosinophil counts in BALF. Augmentation of airway inflammation was also observed in peribronchiolar and perivascular lung areas. Df-specific serum IgE was significantly elevated by ADS airborne particles, but not by CJ-1 soil. Levels of interleukin (IL)-5, IL-13, IL-6, and macrophage inflammatory protein-2 were higher in BALF in mice treated with ADS airborne particles.
These results suggest that substances attached to ADS airborne particles that are not in the original ADS soil may play important roles in immune adjuvant effects and airway inflammation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25386753</pmid><doi>10.1371/journal.pone.0111831</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Airborne particulates Allergens Allergies Aluminum Alveoli Analysis Animals Asthma Asthma - immunology Asthma - metabolism Augmentation Bronchoalveolar lavage Bronchoalveolar Lavage Fluid - immunology Bronchus Cytokines Cytokines - metabolism Disease Models, Animal Dust Dust - immunology Dust particles Dust storms Immunoglobulin E Inflammation Inflammation - immunology Inflammation - metabolism Interleukin Interleukin 13 Interleukin 6 Japan Leukocytes Leukocytes (eosinophilic) Lungs Macrophage inflammatory protein Macrophages Male Medicine Medicine and Health Sciences Mice Nitrates Outdoor air quality Particulates Respiratory System - immunology Respiratory System - metabolism Respiratory tract Respiratory tract diseases Rheumatology Sandstorms Soils Studies University faculty White blood cells |
| title | Influence of Asian dust particles on immune adjuvant effects and airway inflammation in asthma model mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T19%3A15%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20Asian%20dust%20particles%20on%20immune%20adjuvant%20effects%20and%20airway%20inflammation%20in%20asthma%20model%20mice&rft.jtitle=PloS%20one&rft.au=Kurai,%20Jun&rft.date=2014-11-11&rft.volume=9&rft.issue=11&rft.spage=e111831&rft.epage=e111831&rft.pages=e111831-e111831&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0111831&rft_dat=%3Cgale_plos_%3EA418635135%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1622597505&rft_id=info:pmid/25386753&rft_galeid=A418635135&rft_doaj_id=oai_doaj_org_article_1bb23e82fb5543e2b8ebf2811eee2abf&rfr_iscdi=true |