HIV-infection, atherosclerosis and the inflammatory pathway: candidate gene study in a Spanish HIV-infected population
Higher prevalence of atherosclerosis and higher cardiovascular risk is observed in HIV-infected individuals. The biological mechanisms underlying these processes are unclear. Several studies have implicated genetic variants in the inflammatory genes in cardiovascular disease and in HIV natural cours...
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| Veröffentlicht in: | PloS one 2014-11, Vol.9 (11), p.e112279-e112279 |
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| creator | Ibáñez, Laura Velli, Pablo Sebastián Font, Roser Jaén, Angeles Royo, Josep Irigoyen, Daniel Cairó, Mireia De la Sierra, Alejandro Arranz, María Jesús Gallardo, David Dalmau, David |
| description | Higher prevalence of atherosclerosis and higher cardiovascular risk is observed in HIV-infected individuals. The biological mechanisms underlying these processes are unclear. Several studies have implicated genetic variants in the inflammatory genes in cardiovascular disease and in HIV natural course infection.
In this study we have tested the possible association between genetic variants in several inflammatory genes and asymptomatic cardiovascular disease measured by carotid intima media thickness (cIMT) and atherosclerotic plaque presence as dependent variables in 213 HIV-infected individuals. A total of 101 genetic variants in 25 candidate genes have been genotyped. Results were analyzed using Plink and SPSS statistical packages. We have found several polymorphisms in the genes ALOX5 (rs2115819 p = 0.009), ALOX5AP (rs9578196 p = 0.007; rs4769873 p = 0.004 and rs9315051 p = 0.0004), CX3CL1 (rs4151117 p = 0.040 and rs614230 p = 0.015) and CCL5 (rs3817655 p = 0.018 and rs2107538 p = 0.018) associated with atherosclerotic plaque. cIMT mean has been associated with CRP (1130864 p = 0.0003 and rs1800947 p = 0.008), IL1RN (rs380092 p = 0.002) and ALOX5AP (rs3885907 p = 0.02) genetic variants.
In this study we have found modest associations between genetic variants in several inflammatory genes and atherosclerotic plaque or cIMT. Nevertheless, our study adds evidence to the association between inflammatory pathway genetic variants and the atherosclerotic disease in HIV-infected individuals. |
| doi_str_mv | 10.1371/journal.pone.0112279 |
| format | Article |
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In this study we have tested the possible association between genetic variants in several inflammatory genes and asymptomatic cardiovascular disease measured by carotid intima media thickness (cIMT) and atherosclerotic plaque presence as dependent variables in 213 HIV-infected individuals. A total of 101 genetic variants in 25 candidate genes have been genotyped. Results were analyzed using Plink and SPSS statistical packages. We have found several polymorphisms in the genes ALOX5 (rs2115819 p = 0.009), ALOX5AP (rs9578196 p = 0.007; rs4769873 p = 0.004 and rs9315051 p = 0.0004), CX3CL1 (rs4151117 p = 0.040 and rs614230 p = 0.015) and CCL5 (rs3817655 p = 0.018 and rs2107538 p = 0.018) associated with atherosclerotic plaque. cIMT mean has been associated with CRP (1130864 p = 0.0003 and rs1800947 p = 0.008), IL1RN (rs380092 p = 0.002) and ALOX5AP (rs3885907 p = 0.02) genetic variants.
In this study we have found modest associations between genetic variants in several inflammatory genes and atherosclerotic plaque or cIMT. Nevertheless, our study adds evidence to the association between inflammatory pathway genetic variants and the atherosclerotic disease in HIV-infected individuals.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112279</identifier><identifier>PMID: 25383745</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Arteriosclerosis ; Aterosclerosi ; Atherosclerosis ; Biological activity ; Biology and Life Sciences ; Cardiovascular disease ; Cardiovascular diseases ; Carotid Intima-Media Thickness ; Coronary vessels ; Cytokines ; Dependent variables ; Diabetes ; Espanya ; Female ; Gallardo, David ; Genes ; Genetic diversity ; Genetic Markers - genetics ; Genetic polymorphisms ; Genetic research ; Genetic variance ; Glycoproteins ; Health aspects ; Health risk assessment ; Health risks ; HIV ; HIV infections ; HIV Infections - complications ; HIV patients ; HIV-positive persons ; Human immunodeficiency virus ; Humans ; Infeccions per VIH ; Infections ; Inflamació ; Inflammation ; Inflammation - genetics ; Interleukin 1 ; Male ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Persones seropositives ; Plaque, Atherosclerotic - complications ; Plaque, Atherosclerotic - genetics ; Polymorphism, Single Nucleotide ; Population ; Population (statistical) ; Proteins ; Spain ; Stroke ; Studies ; Womens health</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e112279-e112279</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Ibáñez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>cc-by (c) Ibáñez Lladó, Laura et al., 2014 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a></rights><rights>2014 Ibáñez et al 2014 Ibáñez et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c627t-b443144624edb53bb8bf3fe3d2d978571e917128cc4a738572acaeb007758993</citedby><cites>FETCH-LOGICAL-c627t-b443144624edb53bb8bf3fe3d2d978571e917128cc4a738572acaeb007758993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226484/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226484/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,26951,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25383745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ibáñez, Laura</creatorcontrib><creatorcontrib>Velli, Pablo Sebastián</creatorcontrib><creatorcontrib>Font, Roser</creatorcontrib><creatorcontrib>Jaén, Angeles</creatorcontrib><creatorcontrib>Royo, Josep</creatorcontrib><creatorcontrib>Irigoyen, Daniel</creatorcontrib><creatorcontrib>Cairó, Mireia</creatorcontrib><creatorcontrib>De la Sierra, Alejandro</creatorcontrib><creatorcontrib>Arranz, María Jesús</creatorcontrib><creatorcontrib>Gallardo, David</creatorcontrib><creatorcontrib>Dalmau, David</creatorcontrib><title>HIV-infection, atherosclerosis and the inflammatory pathway: candidate gene study in a Spanish HIV-infected population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Higher prevalence of atherosclerosis and higher cardiovascular risk is observed in HIV-infected individuals. The biological mechanisms underlying these processes are unclear. Several studies have implicated genetic variants in the inflammatory genes in cardiovascular disease and in HIV natural course infection.
In this study we have tested the possible association between genetic variants in several inflammatory genes and asymptomatic cardiovascular disease measured by carotid intima media thickness (cIMT) and atherosclerotic plaque presence as dependent variables in 213 HIV-infected individuals. A total of 101 genetic variants in 25 candidate genes have been genotyped. Results were analyzed using Plink and SPSS statistical packages. We have found several polymorphisms in the genes ALOX5 (rs2115819 p = 0.009), ALOX5AP (rs9578196 p = 0.007; rs4769873 p = 0.004 and rs9315051 p = 0.0004), CX3CL1 (rs4151117 p = 0.040 and rs614230 p = 0.015) and CCL5 (rs3817655 p = 0.018 and rs2107538 p = 0.018) associated with atherosclerotic plaque. cIMT mean has been associated with CRP (1130864 p = 0.0003 and rs1800947 p = 0.008), IL1RN (rs380092 p = 0.002) and ALOX5AP (rs3885907 p = 0.02) genetic variants.
In this study we have found modest associations between genetic variants in several inflammatory genes and atherosclerotic plaque or cIMT. Nevertheless, our study adds evidence to the association between inflammatory pathway genetic variants and the atherosclerotic disease in HIV-infected individuals.</description><subject>Adult</subject><subject>Arteriosclerosis</subject><subject>Aterosclerosi</subject><subject>Atherosclerosis</subject><subject>Biological activity</subject><subject>Biology and Life Sciences</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Carotid Intima-Media Thickness</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Dependent variables</subject><subject>Diabetes</subject><subject>Espanya</subject><subject>Female</subject><subject>Gallardo, David</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genetic Markers - genetics</subject><subject>Genetic polymorphisms</subject><subject>Genetic research</subject><subject>Genetic variance</subject><subject>Glycoproteins</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV Infections - complications</subject><subject>HIV patients</subject><subject>HIV-positive persons</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infeccions per VIH</subject><subject>Infections</subject><subject>Inflamació</subject><subject>Inflammation</subject><subject>Inflammation - genetics</subject><subject>Interleukin 1</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Persones seropositives</subject><subject>Plaque, Atherosclerotic - complications</subject><subject>Plaque, Atherosclerotic - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Population (statistical)</subject><subject>Proteins</subject><subject>Spain</subject><subject>Stroke</subject><subject>Studies</subject><subject>Womens 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The biological mechanisms underlying these processes are unclear. Several studies have implicated genetic variants in the inflammatory genes in cardiovascular disease and in HIV natural course infection.
In this study we have tested the possible association between genetic variants in several inflammatory genes and asymptomatic cardiovascular disease measured by carotid intima media thickness (cIMT) and atherosclerotic plaque presence as dependent variables in 213 HIV-infected individuals. A total of 101 genetic variants in 25 candidate genes have been genotyped. Results were analyzed using Plink and SPSS statistical packages. We have found several polymorphisms in the genes ALOX5 (rs2115819 p = 0.009), ALOX5AP (rs9578196 p = 0.007; rs4769873 p = 0.004 and rs9315051 p = 0.0004), CX3CL1 (rs4151117 p = 0.040 and rs614230 p = 0.015) and CCL5 (rs3817655 p = 0.018 and rs2107538 p = 0.018) associated with atherosclerotic plaque. cIMT mean has been associated with CRP (1130864 p = 0.0003 and rs1800947 p = 0.008), IL1RN (rs380092 p = 0.002) and ALOX5AP (rs3885907 p = 0.02) genetic variants.
In this study we have found modest associations between genetic variants in several inflammatory genes and atherosclerotic plaque or cIMT. Nevertheless, our study adds evidence to the association between inflammatory pathway genetic variants and the atherosclerotic disease in HIV-infected individuals.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25383745</pmid><doi>10.1371/journal.pone.0112279</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1622299614 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Recercat; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Arteriosclerosis Aterosclerosi Atherosclerosis Biological activity Biology and Life Sciences Cardiovascular disease Cardiovascular diseases Carotid Intima-Media Thickness Coronary vessels Cytokines Dependent variables Diabetes Espanya Female Gallardo, David Genes Genetic diversity Genetic Markers - genetics Genetic polymorphisms Genetic research Genetic variance Glycoproteins Health aspects Health risk assessment Health risks HIV HIV infections HIV Infections - complications HIV patients HIV-positive persons Human immunodeficiency virus Humans Infeccions per VIH Infections Inflamació Inflammation Inflammation - genetics Interleukin 1 Male Medical research Medicine and Health Sciences Middle Aged Mortality Persones seropositives Plaque, Atherosclerotic - complications Plaque, Atherosclerotic - genetics Polymorphism, Single Nucleotide Population Population (statistical) Proteins Spain Stroke Studies Womens health |
| title | HIV-infection, atherosclerosis and the inflammatory pathway: candidate gene study in a Spanish HIV-infected population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A54%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HIV-infection,%20atherosclerosis%20and%20the%20inflammatory%20pathway:%20candidate%20gene%20study%20in%20a%20Spanish%20HIV-infected%20population&rft.jtitle=PloS%20one&rft.au=Ib%C3%A1%C3%B1ez,%20Laura&rft.date=2014-11-10&rft.volume=9&rft.issue=11&rft.spage=e112279&rft.epage=e112279&rft.pages=e112279-e112279&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0112279&rft_dat=%3Cgale_plos_%3EA418635768%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1622299614&rft_id=info:pmid/25383745&rft_galeid=A418635768&rft_doaj_id=oai_doaj_org_article_005c4aa1e752424fa1c6e4852694a8c9&rfr_iscdi=true |