Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction

The lymphatic vasculature plays a critical role in a number of disease conditions of increasing prevalence, such as autoimmune disorders, obesity, blood vascular diseases, and cancer metastases. Yet, unlike the blood vasculature, the tools available to interrogate the molecular basis of lymphatic dy...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e112548-e112548
Hauptverfasser:	Agollah, Germaine D, Gonzalez-Garay, Manuel L, Rasmussen, John C, Tan, I-Chih, Aldrich, Melissa B, Darne, Chinmay, Fife, Caroline E, Guilliod, Renie, Maus, Erik A, King, Philip D, Sevick-Muraca, Eva M
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adult Aged Apoptosis Autoimmune diseases Biology and Life Sciences Blood Cancer Cell growth Cells, Cultured Congenital diseases Diabetes Endothelial cells Endothelial Cells - pathology Female Fluorescence Gene sequencing Genes Genomics Growth factors Hepatocyte Growth Factor - genetics High-Throughput Nucleotide Sequencing - methods Hospitals Humans I.R. radiation Infrared imaging Inositol Inositol polyphosphate 5-phosphatase Interrogation Kinases Lipids Lymphatic diseases Lymphedema Lymphedema - genetics Lymphedema - pathology Male MAP Kinase Kinase Kinases - genetics MAP Kinase Signaling System Medicine Medicine and Health Sciences Metastases Middle Aged Mutation myo-Inositol-1 (or 4)-monophosphatase Obesity Optical Imaging - methods Phosphatase Phosphatases Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - chemistry Phosphoric Monoester Hydrolases - genetics Point Mutation Proteins Receptors Research and Analysis Methods Science Sequence Analysis, DNA src Homology Domains Studies Vascular diseases
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