Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2 methyltransferases repression

Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances matrix degradation by neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e112384-e112384
Hauptverfasser:	Atta, Hussein, El-Rehany, Mahmoud, Hammam, Olfat, Abdel-Ghany, Hend, Ramzy, Maggie, Roderfeld, Martin, Roeb, Elke, Al-Hendy, Ayman, Raheim, Salama Abdel, Allam, Hatem, Marey, Heba
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Actin Actins - genetics Adenoviridae - genetics Animals Apoptosis Biochemistry Carbon Tetrachloride Cell growth Collagen Collagen Type I - genetics Enhancer of Zeste Homolog 2 Protein Enzyme-Linked Immunosorbent Assay Enzymes Expression vectors Fibrosis Gastroenterology Gelatinase B Gene expression Gene transfer Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors - genetics Growth factors Hepatocyte growth factor Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Hepatology HGF gene Histone-Lysine N-Methyltransferase - metabolism Humans Hydroxyproline Injection Liver Liver cirrhosis Liver Cirrhosis, Experimental - genetics Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - therapy Male Matrix metalloproteinase Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medicine Medicine and Health Sciences Metalloproteinase Methyltransferases - metabolism mRNA Muscle, Smooth Muscles Mutant Proteins - genetics Mutant Proteins - metabolism Mutation Pharmacology Polycomb Repressive Complex 2 - metabolism Proliferating cell nuclear antigen Proteins Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Rodents Saline solutions Signal transduction Smooth muscle Tissue inhibitor of metalloproteinase 1 Tissue Inhibitor of Metalloproteinase-1 - metabolism Transforming growth factor-b1
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