Foreign body response to subcutaneous implants in diabetic rats

Implantation of synthetic matrices and biomedical devices in diabetic individuals has become a common procedure to repair and/or replace biological tissues. However, an adverse foreign body reaction that invariably occurs adjacent to implant devices impairing their function is poorly characterized i...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e110945-e110945
Hauptverfasser:	Socarrás, Teresa Oviedo, Vasconcelos, Anilton C, Campos, Paula P, Pereira, Nubia B, Souza, Jessica P C, Andrade, Silvia P
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal tissues Animals Apoptosis Biological products Biology and Life Sciences Biomarkers - metabolism Blood Glucose Blood vessels Body Weight Cell activation Chemokines Collagen Collagen - metabolism Dermis Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Fibrosis Foreign Bodies Foreign-Body Reaction - immunology Foreign-Body Reaction - metabolism Foreign-Body Reaction - pathology Giant Cells Glucosaminidase Hemoglobin Hemoglobins Hyperglycemia Implantation Implants, Experimental Inflammation Laboratories Macrophages Male Medical equipment Medicine and Health Sciences Monocyte chemoattractant protein 1 Neovascularization, Pathologic Pathology Peroxidase Polyurethane Polyurethane resins Polyurethanes Prostheses and implants Rats Rodents Streptozocin Surgical implants Tissues Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Transplants & implants Tumor necrosis factor-α Vascular endothelial growth factor Wound healing
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