NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells

NPRL-Z-1 is a 4β-[(4"-benzamido)-amino]-4'-O-demethyl-epipodophyllotoxin derivative. Previous reports have shown that NPRL-Z-1 possesses anticancer activity. Here NPRL-Z-1 displayed cytotoxic effects against four human cancer cell lines (HCT 116, A549, ACHN, and A498) and exhibited potent...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e112220
Hauptverfasser:	Wu, Szu-Ying, Pan, Shiow-Lin, Xiao, Zhi-Yan, Hsu, Jui-Ling, Chen, Mei-Chuan, Lee, Kuo-Hsiung, Teng, Che-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Anticancer properties Antigens, Neoplasm - metabolism Antitumor activity Apoptosis Apoptosis - drug effects Ataxia Ataxia telangiectasia mutated protein Ataxia Telangiectasia Mutated Proteins - metabolism Biology and Life Sciences Carcinoma Cell cycle CHK2 protein Cytotoxicity Deoxyribonucleic acid DNA DNA Damage DNA topoisomerase (ATP-hydrolysing) DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Histone H2A Humans Kidney cancer Kidney Neoplasms - drug therapy Kidney Neoplasms - enzymology Kidney Neoplasms - pathology Kinases Laboratories Medicine and Health Sciences Oxygen p53 Protein Phosphorylation Podophyllotoxin - analogs & derivatives Podophyllotoxin - pharmacology Poly-ADP-Ribose Binding Proteins Protein kinase R&D Reactive oxygen species Reactive Oxygen Species - metabolism Renal cell carcinoma Research & development Signal transduction Signal Transduction - drug effects Signaling Topoisomerase II Inhibitors - pharmacology Tumor cell lines Tumor Suppressor Protein p53 - metabolism
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