Surface levels of CD20 determine anti-CD20 antibodies mediated cell death in vitro

The sensitivity of human Burkitt's lymphoma cells to rituximab (Rtx) and tositumomab (Tst) was assessed on cells expressing different levels of CD20 on surface. Cells that harbor low CD20 levels may resists against therapeutics response to CD20-specific antibodies. We postulated that, radiation...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e111113-e111113
Hauptverfasser:	Singh, Vijay, Gupta, Damodar, Arora, Rajesh, Tripathi, Rajendra Prashad, Almasan, Alexandru, Macklis, Roger M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Murine-Derived - pharmacology Antigens, CD20 - genetics Antigens, CD20 - metabolism Antineoplastic Agents - pharmacology Apoptosis B cells Biochemistry Biology and Life Sciences Burkitt's lymphoma Cancer therapies CD20 antigen Cell Cycle - drug effects Cell death Cell Death - drug effects Cell Line, Tumor Cell Membrane - metabolism Cell surface Cell suspensions Cytotoxicity Effectiveness Gene Expression Humans Immunoglobulins Immunophenotyping Immunotherapy Ionizing radiation Irradiation Kinases Kinetics Leukemia Lipids Lymphocytes B Lymphoma Lymphomas Medicine and Health Sciences Membrane potential Membrane Potential, Mitochondrial - drug effects Mitochondria Monoclonal antibodies Mortality Nuclear medicine Oxygen Proteins Radiation Radiation effects Reaction kinetics Reactive oxygen species Reactive Oxygen Species - metabolism Resists Rituximab Targeted cancer therapy Tumors γ Radiation
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