Sertraline reduces IL-1β and TNF-α mRNA expression and overcomes their rise induced by seizures in the rat hippocampus

We recently discovered that the antidepressant sertraline is an effective inhibitor of hippocampus presynaptic Na+ channel permeability in vitro and of tonic-clonic seizures in animals in vivo. Several studies indicate that the pro-inflammatory cytokines in the central nervous system are increased i...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e111665-e111665
Hauptverfasser:	Sitges, María, Gómez, Carlos D, Aldana, Blanca I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressants Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Biology and Life Sciences Blood-brain barrier Brain Central nervous system Cytokines Drug dosages Epilepsy Gene expression Gene Expression Regulation - drug effects Hippocampus Hippocampus - drug effects Hippocampus - metabolism IL-1β In vivo methods and tests Inflammation Inflammation Mediators - metabolism Inoculation Interleukin-1beta - genetics Interleukin-1beta - metabolism Laboratory animals Lipopolysaccharides Lipopolysaccharides - pharmacology Male Medicine and Health Sciences Mental depression Microglia Pentylenetetrazole - adverse effects Permeability Polymerase chain reaction Rats RNA, Messenger Rodents Seizing Seizures Seizures - chemically induced Seizures - drug therapy Seizures - genetics Seizures - metabolism Sertraline Sertraline - administration & dosage Sertraline - pharmacology Sodium channels Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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