LRRK2 transport is regulated by its novel interacting partner Rab32

Leucine-rich repeat kinase 2 (LRRK2) is a multi-domain 280 kDa protein that is linked to Parkinson's disease (PD). Mutations especially in the GTPase and kinase domains of LRRK2 are the most common causes of heritable PD and are also found in sporadic forms of PD. Although the cellular function...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e111632-e111632
Hauptverfasser:	Waschbüsch, Dieter, Michels, Helen, Strassheim, Swantje, Ossendorf, Edith, Kessler, Daniel, Gloeckner, Christian Johannes, Barnekow, Angelika
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Amino Acid Motifs Animals Autophagy Biology and Life Sciences Biomarkers - metabolism Biosynthesis Brain Brain research Cell Compartmentation Cell death Cloning Drosophila Endosomes Endosomes - metabolism Fluorescence Fluorescence microscopy Fractionation G proteins Golgi apparatus Green Fluorescent Proteins - metabolism Guanosine triphosphatases Homology Humans Immunoprecipitation Inflammation Insects Intracellular Space - metabolism Kinases Leucine Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Localization LRRK2 protein Medicine and Health Sciences Mice Mitochondria Movement disorders Mutant Proteins - metabolism Mutation Neurodegenerative diseases NIH 3T3 Cells Parkinson's disease Phagocytosis Plasmids Protein Binding Protein Interaction Domains and Motifs Protein Transport Protein turnover Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - metabolism rab GTP-Binding Proteins - metabolism Research and analysis methods Subcellular Fractions - metabolism Transport Two-Hybrid System Techniques Yeast
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