MiR-30a-3p negatively regulates BAFF synthesis in systemic sclerosis and rheumatoid arthritis fibroblasts

We evaluated micro (mi) RNA-mediated regulation of BAFF expression in fibroblasts using two concomitant models: (i) synovial fibroblasts (FLS) isolated from healthy controls (N) or Rheumatoid Arthritis (RA) patients; (ii) human dermal fibroblasts (HDF) isolated from healthy controls (N) or Systemic...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e111266
Hauptverfasser:	Alsaleh, Ghada, François, Antoine, Philippe, Lucas, Gong, Ya-Zhuo, Bahram, Seiamak, Cetin, Semih, Pfeffer, Sébastien, Gottenberg, Jacques-Eric, Wachsmann, Dominique, Georgel, Philippe, Sibilia, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Analysis Antisense RNA Arthritis Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Autoimmune diseases Autoimmunity B cells B-Cell Activating Factor - biosynthesis B-Cell Activating Factor - genetics B-Lymphocytes - cytology B-Lymphocytes - drug effects Base Sequence Biochemistry, Molecular Biology Biology and life sciences BLyS protein Cell survival Cell Survival - drug effects Control Cytokines Dendritic cells Down-Regulation - drug effects Down-Regulation - genetics Enzyme-linked immunosorbent assay Female Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Gene expression Hostages Humans Interferon-gamma - pharmacology Kinases Life Sciences Lupus Lymphocytes B Male Medicine and Health Sciences MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged miRNA Patients Poly (I:C) Poly I-C - pharmacology Polyinosinic:polycytidylic acid Proteins Repressors Rheumatoid arthritis Rheumatoid factor Ribonucleic acid RNA Scleroderma Scleroderma (Disease) Scleroderma, Systemic - genetics Scleroderma, Systemic - immunology Scleroderma, Systemic - pathology Skin Synthesis Systemic lupus erythematosus Systemic sclerosis Transfection γ-Interferon
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