The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment

The bile acid-sensitive ion channel (BASIC) is a member of the DEG/ENaC family of ion channels. Channels of this family are characterized by a common structure, their physiological functions and modes of activation, however, are diverse. Rat BASIC is expressed in brain, liver and intestinal tract an...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e111549-e111549
Hauptverfasser:	Schmidt, Axel, Lenzig, Pia, Oslender-Bujotzek, Adrienne, Kusch, Jana, Lucas, Susana Dias, Gründer, Stefan, Wiemuth, Dominik
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channels - chemistry Acid Sensing Ion Channels - metabolism Acids Activation Animals Bile Bile acids Bile Acids and Salts - pharmacology Binding sites Biology and Life Sciences Brain Cell Membrane - drug effects Cell Membrane - metabolism Chimeras Chlorpromazine - pharmacology Cholesterol - pharmacology Deoxycholic acid Gadolinium - pharmacology Homeostasis Intestine Ion Channel Gating - drug effects Ion channels Ligands Lipids Liver Mice Physiological aspects Physiology Picrates - pharmacology Plasma Protein Structure, Tertiary Rats Research and Analysis Methods Rodents Sodium channels Structure-Activity Relationship Transmembrane domains Ursodeoxycholic Acid - pharmacology Xenopus laevis
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