Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cells

Accumulating evidence suggests that glucolipotoxicity, arising from the combined actions of elevated glucose and free fatty acid levels, acts as a key pathogenic component in type II diabetes, contributing to β-cell dysfunction and death. Endoplasmic reticulum (ER) stress is among the molecular path...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110875-e110875
Hauptverfasser:	Gjoni, Enida, Brioschi, Loredana, Cinque, Alessandra, Coant, Nicolas, Islam, M Nurul, Ng, Carl K-Y, Verderio, Claudia, Magnan, Christophe, Riboni, Laura, Viani, Paola, Le Stunff, Hervé, Giussani, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation AKT protein Animals Apoptosis Biology and Life Sciences Biosynthesis Biotechnology Cell death Cell Line Cell Survival Ceramide Ceramides - chemistry Diabetes Diabetes mellitus Diabetes Mellitus - metabolism Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress Environmental science Fatty acids Gene expression Glucose Glucose - chemistry Golgi apparatus Golgi Apparatus - metabolism Insulin-Secreting Cells - cytology Insulinoma - metabolism Kinases Localization Medicine Medicine and Health Sciences Metabolism Palmitic Acid - chemistry Phosphorylation Proteins Rats Regulators RNA Interference Rodents Sphingomyelins - chemistry Sphingosine - chemistry Traffic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!