Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity

Altered production of β-amyloid (Aβ) from the amyloid precursor protein (APP) is closely associated with Alzheimer's disease (AD). APP has a number of homo- and hetero-dimerizing domains, and studies have suggested that dimerization of β-secretase derived APP carboxyl terminal fragment (CTFβ, C...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e111553
Hauptverfasser:	Jung, Joo In, Premraj, Sasha, Cruz, Pedro E, Ladd, Thomas B, Kwak, Yewon, Koo, Edward H, Felsenstein, Kevin M, Golde, Todd E, Ran, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino acid sequence Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Amyloid Precursor Protein Secretases - metabolism Animals Biochemistry Biology and Life Sciences Brain research CHO Cells Cleavage Cricetinae Cricetulus Culture Media, Conditioned - chemistry Dimerization Dimers Enzyme-Linked Immunosorbent Assay Enzymes Lysine Mass Spectrometry Medicine Medicine and Health Sciences Mutation Neurosciences Precursors Protein Multimerization Protein Structure, Tertiary Proteins Recombinant Proteins - chemistry Secretase Substrates β-Amyloid
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