Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay

Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulation studies have traditionally relied on...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110800
Hauptverfasser:	Loh, Cheryl C Y, Suwanarusk, Rossarin, Lee, Yan Quan, Chan, Kitti W K, Choy, Kit-Ying, Rénia, Laurent, Russell, Bruce, Lear, Martin J, Nosten, François H, Tan, Kevin S W, Chow, Larry M C
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adenosine Triphosphate - pharmacology Animals Apoptosis Biology and Life Sciences Biomarkers - metabolism Boron Compounds - metabolism Chloroquine Chloroquine - pharmacology Clinical isolates Confocal microscopy Copy number DNA Copy Number Variations - genetics Drug resistance Drug Resistance - drug effects Drug Resistance - genetics Efflux Erythrocytes Fluorescence Fluorescent Dyes - metabolism Genes, Protozoan Haplotypes Immunology Inhibition Inhibitory Concentration 50 Laboratories Malaria Medicine Medicine and Health Sciences Mibefradil - pharmacology Microscopy Microsomes Microsomes - drug effects Microsomes - metabolism Molecular Probe Techniques - instrumentation Mutation Parasites Parasites - drug effects Parasites - metabolism Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Polymorphism, Genetic Pretreatment Reproducibility of Results Research and Analysis Methods Reversing Science Verapamil - pharmacology
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